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Articles 31 - 45 of 45
Full-Text Articles in Life Sciences
Light Scattering Characterization Of Elastin-Like Polypeptide Trimer Micelles, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Light Scattering Characterization Of Elastin-Like Polypeptide Trimer Micelles, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Undergraduate Research Posters 2016
Elastin-Like Polypeptides (ELP) can be used to form thermo-reversible vehicles for drug delivery systems. The ELP nanoparticles are composed of three-armed star polypeptides. Each of the three arms extending from the negatively charged foldon domain includes 20 repeats of the (GVGVP) amino acid sequence. The ELP polymer chains are soluble at room temperature and become insoluble at the transition temperature (close to 50 oC), forming micelles. The size and shape of the micelle is dependent on the temperature and the pH of solution, along with the concentration of the Phosphate Buffered Saline (PBS) solvent. The technique of Depolarized Dynamic Light …
African Clawed Toads’ Responses To Visual And Lateral Line Stimuli, Marko Milosavljevic, Kevin Goth
African Clawed Toads’ Responses To Visual And Lateral Line Stimuli, Marko Milosavljevic, Kevin Goth
Undergraduate Research Posters 2016
The African Clawed Toad, Xenopus laevis, is an aquatic species commonly found throughout Sub-Saharan Africa. Adults use vision to sense movements and lateral line to sense vibrations in the water. Here, we analyze the effectiveness of the toads' vision and lateral line systems individually and in combination. This study will help us understand how Xenopus utilizes sensory information to capture prey. We tested which sensory system elicits greater responses, how stimulus angle and distance affect the probability of a response, and if the toads respond equally to visual and lateral line stimuli. We found that a combination of both visual …
Identifying Patterns Of Stress Through Biological Markers, Kristyn Oravec
Identifying Patterns Of Stress Through Biological Markers, Kristyn Oravec
Undergraduate Research Posters 2016
technique, the angle of incidence of the ion beam was 67° from the surface normal,
Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli
Bioinformatic Analysis Of The Sodium Hydrogen Exchanger Protein In Plasmodium Yoelii, Jamira Virk, Raghavendra Yadavalli
Undergraduate Research Posters 2016
Since its discovery over 100 years ago, malaria has been the most important parasitic disease in the world. Malaria affects about 300 to 500 million people every year; killing 5 million people every year. The most virulent causative agent in humans is Plasmodium falciparum; it is an important member of the phylum Apicomplexa, which also includes Toxoplasma gondii. These organisms contain specialized, unique structures, including rhoptry organelles. In Plasmodium and Toxoplasma gondii, they assist invasion into the host cell. Analyses have been performed on proteins located in rhoptries in Toxoplasma and Plasmodium. Among the proteins that have been analyzed, the …
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Undergraduate Research Posters 2016
The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. Transmitted by the tsetse fly, T. brucei proliferates in the bloodstream of its mammalian host and evades the host's immune response by regularly switching its major surface antigen, VSG, which forms a thick coat on its cell membrane. VSGs are exclusively expressed from sub-telomeric regions of the T. brucei genome in a strictly monoallelic fashion. Telomeres, DNA-protein complexes located at chromosome ends, help maintain chromosome stability and integrity. We have also found that telomere proteins are important for regulating VSG expression and switching. We are …
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Undergraduate Research Posters 2016
Genetic recombination is essential in order to create diversity amongst all of the genetic information. Crossovers also contribute to segregation of homologous chromosomes to opposite spindle poles during the first meiotic division. Meiotic strand exchange in Saccharomyces cerevisiae, budding yeast, aims to diversify genetic information in the resulting gametes which in budding yeast are called spores. While Dmc1 and Rad51 are two proteins that are known to play a role in double strand break (DSB) repair, the exact function of Rad51 is still unclear. It is known that Rad51 is responsible for strand exchange in mitosis, but it is still …
Unraveling The Dose-Response Puzzle Of L. Monocytogenes: A Mechanistic Approach, S. M.Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu
Unraveling The Dose-Response Puzzle Of L. Monocytogenes: A Mechanistic Approach, S. M.Ashrafur Rahman, Daniel Munther, Aamir Fazil, Ben Smith, Jianhong Wu
Mathematics and Statistics Faculty Publications
Food-borne disease outbreaks caused by Listeria monocytogenes continue to impose heavy burdens on public health in North America and globally. To explore the threat L. monocytogenes presents to the elderly, pregnant woman and immuno-compromised individuals, many studies have focused on in-host infection mechanisms and risk evaluation in terms of dose-response outcomes. However, the connection of these two foci has received little attention, leaving risk prediction with an insufficient mechanistic basis. Consequently, there is a critical need to quantifiably link in-host infection pathways with the dose-response paradigm. To better understand these relationships, we propose a new mathematical model to describe the …
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Undergraduate Research Posters 2016
Twenty-four water samples were taken from twelve sites throughout the Cuyahoga watershed from upstream to downstream within two separate occasions. Twelve samples were taken on May 25th, 2016 with no prior precipitation and the conditions were calm, and twelve samples were taken on July14, 2016 when high precipitation had occurred and water conditions were much more diverse. Using the Automated Discrete Analyzer, the concentrations of phosphorus could be analyzed and differentiated between Total Phosphorus and Soluble Reactive Phosphorus. In comparison to the Environmental Protection Agency whose target concentrations for rivers is .05ppm, in both cases of the experiment the hypothesis …
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Undergraduate Research Posters 2016
Skeletal muscle regeneration relies on myoblast stem cell differentiation and is a crucial response to muscle injury caused by trauma and numerous diseases. In skeletal myoblasts, cell death and differentiation are mutually exclusive biological endpoints that are both induced by culture in differentiation media. MyoD, the master muscle- specific transcription factor, is well-known to regulate the expression of muscle specific genes such as myogenin and the ensuing differentiation. However, we have previously reported that MyoD also plays a critical role in the expression of PUMA and apoptosis, rather than myogenin and differentiation, in a subset of myoblasts, thus diminishing the …
How Does Educational Opportunities Influence Decisions For Nigerian Girls And The Society?, Shalonda Swanson
How Does Educational Opportunities Influence Decisions For Nigerian Girls And The Society?, Shalonda Swanson
Undergraduate Research Posters 2016
This paper raises questions about educational opportunities for Nigerian girls to understand if traditional Islamic or Western education influence the girls on various factors; including, their religious connections, optimism for their future, and the value in Islamic education compared to Western education. To discuss the current status of the country the paper discusses the historical underlying factors that influenced Nigeria's policies for educational opportunities for girls. Nigeria has struggled with gender disparities that disproportionately provided educational opportunities for boys at an increased rate compared to girls. This research reports the traditional values that restricted girls' access to education and the …
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Undergraduate Research Posters 2016
Temperature sensitive nanoparticles (E20F) were generated from a construct of three chains of Elastin- Like Polypeptides (ELP) linked to a negatively charged foldon domain. This ELP system was mixed at different ratios with a single linear chain of ELP (H40L) which was deprived of the foldon domain. The mixed system is soluble at room temperature and at a transition temperature will form swollen micelles with the hydrophobic linear chains hidden inside. This system was studied using Depolarized Dynamic Light Scattering (DDLS) and Static Light Scattering (SLS) to model the size, shape, and internal structure of the mixed micelles. The mixed …
Elimination Of Acoustic Noise In Stm Analysis Of Polymer Crystallization On Au (111), Mark Bowling, William Myers
Elimination Of Acoustic Noise In Stm Analysis Of Polymer Crystallization On Au (111), Mark Bowling, William Myers
Undergraduate Research Posters 2016
Organic molecules offer a potentially cheap and environmentally friendly alternative to traditional silicon based electronics. The main limitation is that they are not as conductive as their inorganic counter parts. By crystalizing organic molecules, it is possible to increase the conductivity so that they can be more competitive with silicon electronics. This project examines the crystallization of polymers through selfassembly on the Au(111) surface reconstruction. The success of the crystallization is characterized with scanning tunneling microscopy (STM). In order to achieve high resolution STM images, we examined acoustic isolation by enclosing the microscope within a rubber-coated box, which was not …
Effects Of Flanking Bigrams On Decision Performance In Selective And Divided Attention Tasks, Nicole Russo, Jamie Rodman
Effects Of Flanking Bigrams On Decision Performance In Selective And Divided Attention Tasks, Nicole Russo, Jamie Rodman
Undergraduate Research Posters 2016
In previous research, lexical decision performance for word targets flanked by pairs of letters was better when flankers consisted of letters in the target (e.g., BI BIRD RD; RD BIRD BI; IB BIRD DR; DR BIRD IB) than of non-target letters (e.g., CE BIRD NT). Also, performance was better when flankers contained letters ordered as in the target (e.g., BI BIRD RD; RD BIRD BI) than switched (e.g., IB BIRD DR; DR BIRD IB), but flanker order relative to the target did not affect performance. That flankers affect lexical decision performance indicates that participants do not attend selectively to the …
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
Undergraduate Research Posters 2016
Introduction Injurious falls have risen significantly in the past decade, raising concerns about the efficacy of fall prevention programs. The purpose of this study was to analyze the correlation between perceived and observed balance measures used in a falls prevention program. Methods Subjects (S) were 70 (F), 59 (F), and 73(M). They were taught the Rate of Perceived Stability (RPS), a perceived measure of balance intensity and completed the Berg Balance Test (Berg), Timed up and Go (TUG), and Activities Specific Balance Confidence Scale (ABC). The Berg and TUG are observed measures and the ABC is a perceived measure. Last, …
Which Clouds Are Important: Variation Of Cloud Size Distribution Functions In Large Eddy Simulations, Dorothy Pharis, Nicholas Barron
Which Clouds Are Important: Variation Of Cloud Size Distribution Functions In Large Eddy Simulations, Dorothy Pharis, Nicholas Barron
Undergraduate Research Posters 2016
Accurately measuring and modeling clouds is an important factor in improving weather and climate prediction. One way of measuring the most important cloud size in a cloud field is a cloud size distribution (CSD) function, or the number of clouds per cloud size within the field. The information from a cloud size distribution can then be used to determine which cloud sizes contribute the most to cloud cover. This research focuses on creating and comparing cloud size distributions for a variety of cumulus cloud fields generated by Large Eddy Simulations (LES), a high resolution computer model. Our work found that …