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Full-Text Articles in Life Sciences
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Expression Of Recombinant Proteins In Bacteria For Antibody Production, John Sabljic, Anton Denisyuk, Hallie Schmolz, Olivera Prica
Undergraduate Research Posters 2016
The protozoan parasite Trypanosoma brucei causes fatal African trypanosomiasis in humans and nagana in cattle. Transmitted by the tsetse fly, T. brucei proliferates in the bloodstream of its mammalian host and evades the host's immune response by regularly switching its major surface antigen, VSG, which forms a thick coat on its cell membrane. VSGs are exclusively expressed from sub-telomeric regions of the T. brucei genome in a strictly monoallelic fashion. Telomeres, DNA-protein complexes located at chromosome ends, help maintain chromosome stability and integrity. We have also found that telomere proteins are important for regulating VSG expression and switching. We are …
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Identification Of Factors That Mediate Strand Exchange During Early Meiosis At Low Double Strand Break Levels, Isaac Kuragayla, Rima Sandhu
Undergraduate Research Posters 2016
Genetic recombination is essential in order to create diversity amongst all of the genetic information. Crossovers also contribute to segregation of homologous chromosomes to opposite spindle poles during the first meiotic division. Meiotic strand exchange in Saccharomyces cerevisiae, budding yeast, aims to diversify genetic information in the resulting gametes which in budding yeast are called spores. While Dmc1 and Rad51 are two proteins that are known to play a role in double strand break (DSB) repair, the exact function of Rad51 is still unclear. It is known that Rad51 is responsible for strand exchange in mitosis, but it is still …
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Phosphorus Concentrations In The Cuyahoga River Watershed Linked To Anthropogenic Inputs, Christopher Kasden
Undergraduate Research Posters 2016
Twenty-four water samples were taken from twelve sites throughout the Cuyahoga watershed from upstream to downstream within two separate occasions. Twelve samples were taken on May 25th, 2016 with no prior precipitation and the conditions were calm, and twelve samples were taken on July14, 2016 when high precipitation had occurred and water conditions were much more diverse. Using the Automated Discrete Analyzer, the concentrations of phosphorus could be analyzed and differentiated between Total Phosphorus and Soluble Reactive Phosphorus. In comparison to the Environmental Protection Agency whose target concentrations for rivers is .05ppm, in both cases of the experiment the hypothesis …
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Effect Of P38 Kinase And Cell Cycle Position On The Expression Of The Pro-Apoptotic Bcl2 Family Member Puma In Skeletal Myoblasts, Victoria Bensimon, Briana Boslett
Undergraduate Research Posters 2016
Skeletal muscle regeneration relies on myoblast stem cell differentiation and is a crucial response to muscle injury caused by trauma and numerous diseases. In skeletal myoblasts, cell death and differentiation are mutually exclusive biological endpoints that are both induced by culture in differentiation media. MyoD, the master muscle- specific transcription factor, is well-known to regulate the expression of muscle specific genes such as myogenin and the ensuing differentiation. However, we have previously reported that MyoD also plays a critical role in the expression of PUMA and apoptosis, rather than myogenin and differentiation, in a subset of myoblasts, thus diminishing the …
How Does Educational Opportunities Influence Decisions For Nigerian Girls And The Society?, Shalonda Swanson
How Does Educational Opportunities Influence Decisions For Nigerian Girls And The Society?, Shalonda Swanson
Undergraduate Research Posters 2016
This paper raises questions about educational opportunities for Nigerian girls to understand if traditional Islamic or Western education influence the girls on various factors; including, their religious connections, optimism for their future, and the value in Islamic education compared to Western education. To discuss the current status of the country the paper discusses the historical underlying factors that influenced Nigeria's policies for educational opportunities for girls. Nigeria has struggled with gender disparities that disproportionately provided educational opportunities for boys at an increased rate compared to girls. This research reports the traditional values that restricted girls' access to education and the …
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Light Scattering Study Of Mixed Micelles Made From Elastin-Like Polypeptide Linear Chains And Trimers, Ilona Tsuper, Daniel Terrano, Adam Maraschky
Undergraduate Research Posters 2016
Temperature sensitive nanoparticles (E20F) were generated from a construct of three chains of Elastin- Like Polypeptides (ELP) linked to a negatively charged foldon domain. This ELP system was mixed at different ratios with a single linear chain of ELP (H40L) which was deprived of the foldon domain. The mixed system is soluble at room temperature and at a transition temperature will form swollen micelles with the hydrophobic linear chains hidden inside. This system was studied using Depolarized Dynamic Light Scattering (DDLS) and Static Light Scattering (SLS) to model the size, shape, and internal structure of the mixed micelles. The mixed …
Elimination Of Acoustic Noise In Stm Analysis Of Polymer Crystallization On Au (111), Mark Bowling, William Myers
Elimination Of Acoustic Noise In Stm Analysis Of Polymer Crystallization On Au (111), Mark Bowling, William Myers
Undergraduate Research Posters 2016
Organic molecules offer a potentially cheap and environmentally friendly alternative to traditional silicon based electronics. The main limitation is that they are not as conductive as their inorganic counter parts. By crystalizing organic molecules, it is possible to increase the conductivity so that they can be more competitive with silicon electronics. This project examines the crystallization of polymers through selfassembly on the Au(111) surface reconstruction. The success of the crystallization is characterized with scanning tunneling microscopy (STM). In order to achieve high resolution STM images, we examined acoustic isolation by enclosing the microscope within a rubber-coated box, which was not …
Effects Of Flanking Bigrams On Decision Performance In Selective And Divided Attention Tasks, Nicole Russo, Jamie Rodman
Effects Of Flanking Bigrams On Decision Performance In Selective And Divided Attention Tasks, Nicole Russo, Jamie Rodman
Undergraduate Research Posters 2016
In previous research, lexical decision performance for word targets flanked by pairs of letters was better when flankers consisted of letters in the target (e.g., BI BIRD RD; RD BIRD BI; IB BIRD DR; DR BIRD IB) than of non-target letters (e.g., CE BIRD NT). Also, performance was better when flankers contained letters ordered as in the target (e.g., BI BIRD RD; RD BIRD BI) than switched (e.g., IB BIRD DR; DR BIRD IB), but flanker order relative to the target did not affect performance. That flankers affect lexical decision performance indicates that participants do not attend selectively to the …
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
The Relationship Between Observed And Perceived Measures Of Balance Stability, Lrenzo Bianco, John Demarco, Sarah Gualtier
Undergraduate Research Posters 2016
Introduction Injurious falls have risen significantly in the past decade, raising concerns about the efficacy of fall prevention programs. The purpose of this study was to analyze the correlation between perceived and observed balance measures used in a falls prevention program. Methods Subjects (S) were 70 (F), 59 (F), and 73(M). They were taught the Rate of Perceived Stability (RPS), a perceived measure of balance intensity and completed the Berg Balance Test (Berg), Timed up and Go (TUG), and Activities Specific Balance Confidence Scale (ABC). The Berg and TUG are observed measures and the ABC is a perceived measure. Last, …
Which Clouds Are Important: Variation Of Cloud Size Distribution Functions In Large Eddy Simulations, Dorothy Pharis, Nicholas Barron
Which Clouds Are Important: Variation Of Cloud Size Distribution Functions In Large Eddy Simulations, Dorothy Pharis, Nicholas Barron
Undergraduate Research Posters 2016
Accurately measuring and modeling clouds is an important factor in improving weather and climate prediction. One way of measuring the most important cloud size in a cloud field is a cloud size distribution (CSD) function, or the number of clouds per cloud size within the field. The information from a cloud size distribution can then be used to determine which cloud sizes contribute the most to cloud cover. This research focuses on creating and comparing cloud size distributions for a variety of cumulus cloud fields generated by Large Eddy Simulations (LES), a high resolution computer model. Our work found that …
Acoustic Objective And Subjective Measurements Of Noise Levels In Various Places Of Worship And The Potential Consequences On The Auditory System, Celeste Thomas
Undergraduate Research Posters 2015
The purpose of this study is to record the objective and subjective measurements of noise levels in ten religious institutions of various faiths: Apostolic/Pentecostal, Baptist, Catholic, Muslim, Non-Denominational, and Seven-Day Adventist places of worship within the greater Cleveland area; in conjunction with the assessing the hearing sensitivity of the ministerial staff members who are most susceptible to prolonged noise exposure. The objective is to generate a statistical analysis of the objective acoustical measurements of primary church services of all participating religious institutions determine if the noise levels are loud enough to cause potential harm to the auditory system. The researcher …
Distribution Of Sphaeriid Clams In Lake Erie Twenty-Five Years After Invasion Of Dreissena, Michael Keller
Distribution Of Sphaeriid Clams In Lake Erie Twenty-Five Years After Invasion Of Dreissena, Michael Keller
Undergraduate Research Posters 2015
Clams in the family Sphaeriidae are widespread native mollusk species that are often overlooked. The distribution of these organisms in Lake Erie has not been examined in the 25 years since the initial invasion of the zebra mussel, Dreissena polymorpha. Carr and Hiltunen identified 10 species of Sphaeriidae in Western Lake Erie in 1961, of which Pisidium casertanum, P. compressum, P. nitidum, Sphaerium corneum, and S. striatinum and Musculium transversum, contributed 89.7% of all fingernail and pea clams sampled and were considered common. Four other species were reported as rare. Our research examines whether the distribution of Sphaeriid clams in …
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Designing Tuftsin Conjugate For Directing Antimicrobial Ionophores To Macrophages, Sokhna Seck, Zeenat Razvi
Undergraduate Research Posters 2015
For all microorganisms, acquisition of metal ions is essential for survival in the environment or their infected host. Metal ions are required in many biological processes as cofactors for proteins or structural elements for enzymes. These ions play a role in chemotaxis, phosphorylation, transport of sugars and proteins, and initiation of DNA replication, among other things. It is critical for bacteria to ensure that metal uptake and availability meet its physiological needs; too little can impede these important biological processes, while too much can be toxic leading to radical formation which can cause damage to proteins and cell structures (Porcheron, …
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Statistical Analysis Of Dasi Questionnaire And Modeling The Prediction Of Heart Failure Risk In Patients, Christian Negron
Undergraduate Research Posters 2015
9,880 patients were asked to complete the DASI questionnaire along with other questions to assess the predictability of heart failure risk. In this paper we attempt to reduce the amount of questions asked by hierarchical clustering of the question responses to determine if there is a change in the predictability of heart failure risk in patients. The data was modeled using Cox hazards multiple regression and validated through ROC and AUC. Our validation models show there is no difference between the usage of 12 and 6 DASI questions, therefore improving the simplicity of the questionnaire. Abbreviations: DASI, Duke Activity Status …
Optimizing The Design And Potency Of Diterpenic Acid Derivatives To Improve Cell Membrane Permeability And Hsp27 Targeting Characteristics, Aicha Quamine
Undergraduate Research Posters 2015
Heat shock protein 27 (Hsp27) acts as a protective protein allowing it to play an integral role in aiding cancer cell resistance. Stress-induced Hsp 27 overexpression aids in the stabilization of partially denatured proteins to establish protein refolding resulting in thermotolerance, inhibition of apoptosis, cytoprotection, etc. As a result of rapid proliferation and general instability, cancer cells exhibit increased dependency on the support of Hsp 27 and it’s chaperone proteins, therefore generating an ideal target for anticancer therapy. Copalic acid, a clerodane diterpenoid, has already been confirmed in effective chaperone inhibition and antiproliferative synergistic effect. We hypothesize that by optimizing …
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Dual Stimuli Response Frequency And Stimulus Choice Of The African Clawed Frog, Xenopus Laevis, When Presented With Two Stimuli, Mingo Rolince, Heidi Pignolet, Alexa Hoy
Undergraduate Research Posters 2015
This preliminary study examines responses of African Clawed Frogs to simultaneous presentation of two stimuli. Frogs were tested in a round arena with water 4 cm deep. Four stimulus rods driven via computer-controlled stepper motors were concealed in a screen suspended above the water. These rods could present a lateral line stimulus, a visual stimulus, or a combination of both. Overall, reactions and no reactions were evenly distributed--51.1% and 48.9%, respectively. Frogs responded more frequently to rostral than caudal stimuli (chi-squared 20.8, df=11, p < 0.04). Frogs reacted more to stimuli between -90° and 90°. Turn angle depended linearly on stimulus angle (e.g., Turn angle = 0.44 + 0.64 x Stimulus angle; pslope < 0.0001; R2adj = 69.5%). (The distributions of stimulus angles appear slightly skewed as often the same stimulus rod was retested after the frog responded and partially oriented towards it, prompting a second test with smaller angles.) Two stimuli did not elicit more responses than one stimuli (P=0.25). The frogs’ choice of stimulus depended primarily on stimulus proximity and angle, not stimulus type. When presented with two stimuli, the frog chose the nearer stimulus and the more rostral stimulus (p < 0.0001). The largest factor in predicting the frog’s choice of stimuli seems to be the linear distance from the stimuli to the frog.
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Investigating Rhoptry Gene Conservation Between Plasmodium Yoelii And Plasmodium Falciparum Using The Polymerase Chain Reaction For Dna Amplification, Brooke Burkhalter
Undergraduate Research Posters 2015
In order to obtain a tangible basis for vaccine targets, it is crucial to understand the role of proteins at the site of invasion. In previous study, 27 novel rhoptry proteins were identified by MudPIT analysis and immunoelectron microscopy. In this investigation, the conservation of rhoptry genes between Plasmodium yoelii and Plasmodium falciparum was assessed. From the previously identified rhoptry genes, 14 were investigated with the orthologues/paralogues of the Plasmodium falciparum, Plasmodium yoelii, Plasmodium chabaudi, and Plasmodium berghei. Also, primers designed for the 14 Plasmodium yoelli rhoptry genes were used to test DNA amplification with the PCR. Amplification of Plasmodium …
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Cultural Differences In Coping And Depression Between Individuals Of Middle-Eastern And Non-Arab Backgrounds, Khadeja Najjar
Undergraduate Research Posters 2015
The Middle Eastern (Arab) demographic is a growing, yet neglected cultural group in mental health research. While Arabs are more predisposed to depression than other ethnic groups in US, little is known about mechanisms that account for this risk. One set of mechanisms may be the use of ineffective (maladaptive) coping or insufficient use of effective (adaptive) coping responses, which are robust predictors of depression in US samples, but virtually unexamined in Arabs. Further, the effect of a coping is influenced by culture, which, for Arabs, may change as a function of acculturation. Thus, the present study aimed to examine …
Deducing Shape Of Anisotropic Particles In Solution From Light Scattering: Spindles And Nanorods, Ilona Tsuper, Dan Terrano
Deducing Shape Of Anisotropic Particles In Solution From Light Scattering: Spindles And Nanorods, Ilona Tsuper, Dan Terrano
Undergraduate Research Posters 2015
Depolarized Dynamic light scattering (DDLS) enables to measure in situ rotational and translational diffusion of nanoparticles suspended in solution. Their size, shape, diffusion, and intermolecular interactions can be interred then from DDLS data using various models of diffusion. Incorporating DDLS to analyze the dimensions of easily imaged elongated particles, such as Iron (III) oxyhydroxide Spindles (FeOOH) and gold coated Nanorods, will allow a deeper understanding between rotational/translational diffusion and size distribution of hard-to-image anisotropic wet systems such as micelles, microgels, and protein complexes. The emphasis of this study was to look at the aged FeOOH Spindle sample, and explore the …
Can We Increase The Intensity Of Pro-Active Balance Exercises?, Joshua Lilly, Elizabeth Antonik
Can We Increase The Intensity Of Pro-Active Balance Exercises?, Joshua Lilly, Elizabeth Antonik
Undergraduate Research Posters 2015
Balance training has been shown to be effective in preventing or lessening the severity of falls among older adults. This training can be proactive or reactive; however, the relative effectiveness of each and the necessary dosages are not known. The purpose of this research was to adapt an existing protocol for slip testing (reactive training) and video-game balance training (proactive) to better accommodate the abilities of older adults. We tested iteratively the initial protocols, set-ups, and equipment with a group of adults age 55 years and older and devised new protocols and equipment for each. After observing the subjects’ participation …
Invasive Species Facilitation In Bioswales And Rain Gardens In Greater Cleveland, Brittany Dalton
Invasive Species Facilitation In Bioswales And Rain Gardens In Greater Cleveland, Brittany Dalton
Undergraduate Research Posters 2015
Stormwater management features such as bioretention systems and rain gardens provide valuable ecosystem services. They are ecologically engineered to counteract surrounding urban land use practices. However, new stormwater management features may also create an environment for invasive plant species. Invasive plants can affect ecosystem services, and have devastating economic impacts. This study was conducted to determine connections between surrounding land use and maintenance practices in stormwater management features throughout Greater Cleveland and the presence of invasive plant species. Initial site visits were conducted for 164 bioretention systems and rain gardens in Greater Cleveland. They were analyzed for physical characteristics, surrounding …
Case Transition Format And Lexical Decision Performance: Does Spacing Reduce The Benefit Of Orthographic Regularity?, Kristyn Oravec, Maryam Assar, Hannah Princic
Case Transition Format And Lexical Decision Performance: Does Spacing Reduce The Benefit Of Orthographic Regularity?, Kristyn Oravec, Maryam Assar, Hannah Princic
Undergraduate Research Posters 2015
Some models of visual word identification propose that identification is analytic— mediated exclusively by letter identification. However, some studies have shown that there are phenomena that suggest a route to word identification involves holistic stimulus properties. In previous research, using a lexical decision task, in which participants are asked to determine whether letter strings are words or nonwords, we have found that response times to orthographically regular words (i.e., lowercase, uppercase, and initial uppercase formats) are faster than those to orthographically irregular words (i.e., words that include a case transition other than initial uppercase to lowercase). In this experiment, we …
Balance Training Application Of A Systematic Framework For Clinical Decision Making In Therapeutic Gaming For Older Adults, Brian Boccieri
Balance Training Application Of A Systematic Framework For Clinical Decision Making In Therapeutic Gaming For Older Adults, Brian Boccieri
Undergraduate Research Posters 2015
Falling is a major health concern for older adults. Balance is crucial in order to prevent falls. For balance to be functional an individual must be able to maintain balance while focusing on other tasks. For example, an individual must focus on more than just staying upright during walking while drinking a mug of coffee, or during standing while washing dishes. There are a countless number of daily activities that challenge balance. One of the problems with current clinical balance rehabilitation is that the training is often completed using isolated exercises that do not include the various other cognitive and …
Assaying The Splicing Activity Of Novel Human Disease Variants Of U4atac Snrna, Maitri K. Patel, Rosemary C. Dietrich
Assaying The Splicing Activity Of Novel Human Disease Variants Of U4atac Snrna, Maitri K. Patel, Rosemary C. Dietrich
Undergraduate Research Posters 2015
In eukaryotes, pre-messenger RNA (pre-mRNA) splicing is an essential process in gene expression. Splicing is carried out by a dynamic multi-megadalton RNA-protein complex known as the spliceosome. Sequential transesterification reactions catalyzed by the spliceosome convert pre-mRNA to mRNA by removing the intervening sequences (introns) and joining the coding sequences (exons) together. Small nuclear RNAs (snRNAs) are essential splicing factors. Biallelic mutations of the human RNU4ATAC gene, which codes for U4atac snRNA, have been identified in patients diagnosed with Microcephalic Osteodysplastic Primordial Dwarfism type I (MOPD I). MOPD I is an autosomal recessive disorder characterized by extreme intrauterine growth retardation, multiple …
Regulation Of Sister Chromatid Cohesion By Eco-1 And Wapl-1 During Meiosis And Mitosis, Kyle T. Schroeder
Regulation Of Sister Chromatid Cohesion By Eco-1 And Wapl-1 During Meiosis And Mitosis, Kyle T. Schroeder
Undergraduate Research Posters 2015
Cohesin is a widely conserved, tetrameric protein complex that tethers replicated sister chromatids during meiosis and mitosis. Two cohesin subunits, SMC-1 and SMC-3, and a third subunit, the α-kleisin, form a ring proposed to encircle sister chromatids. Different kleisins associate with cohesin during mitosis and meiosis. SCC-1 is the mitotic kleisin. Meiotic cohesin can associate with either REC-8 or COH-3/4. REC-8 and COH-3/4 cohesins differ greatly in their functional properties, indicating that the kleisin determines meiotic cohesin function. Early in meiosis, REC-8 and COH-3/4 cohesins are triggered to become cohesive at different times and by different mechanisms. Later in meiosis, …
Cell Surface Sialylation Status Of Monocytes And Macrophages, Henry Wang, Dan Wang
Cell Surface Sialylation Status Of Monocytes And Macrophages, Henry Wang, Dan Wang
Undergraduate Research Posters 2015
Sialic acids (SAs), a family of 9-carbon containing acidic monosaccharides, often terminate the glycan structures of cell surface glycoconjugates such as glycoproteins and glycolipids. The levels and linkages of sialic acids named as sialylation status vary as cell environment changes related to both physiological and pathological processes. Changes in sialylation of cell surface modulate cellular activity. SAs are highly involved in the immune system, however, the sialylation status related to individual immune cells and their activation state and functions are still unknown. In this study, we used a newly developed LC-MS/MS method to examine the cellular SA content during THP-1 …
Preliminary Investigation Of The Role Of Open Bigrams In Word Perception: Is There A Benefit To Having Flankers That Consist Of Letters In The Word?, Maryam Assar, Kristyn Oravec, Hannah Princic, Amy Palinski
Preliminary Investigation Of The Role Of Open Bigrams In Word Perception: Is There A Benefit To Having Flankers That Consist Of Letters In The Word?, Maryam Assar, Kristyn Oravec, Hannah Princic, Amy Palinski
Undergraduate Research Posters 2015
Most investigators of word identification agree that information is processed through a hierarchical system in which units at progressively higher levels respond to features, letters, letter combinations (e.g., pairs, or bigrams), and possibly words. Grainger et al. (2014) found support for the role of adjacent-letter bigrams in an experiment in which participants saw target strings flanked by bigrams, such as BI BIRD RD and CE BIVS NT, and judged whether the targets were words. They found, for words, that flanking bigrams facilitated performance when the flanking bigrams contained letters from the target, and that the order of bigrams relative to …
Novel Regulation Of The Pro-Apoptotic Protein Puma In Response To Hypoxia, Mareem Ali, Brianna Boslett
Novel Regulation Of The Pro-Apoptotic Protein Puma In Response To Hypoxia, Mareem Ali, Brianna Boslett
Undergraduate Research Posters 2015
Ischemic injury in skeletal muscle caused by hypoxic (low oxygen) conditions occurs in response to vascular and musculoskeletal traumas, diseases and following reconstructive surgeries. Hypoxia induces apoptotic cell death. We have reported that the protein PUMA plays a critical role in the apoptosis of myoblasts in response to culture in differentiation media as well as exposure to DNA damaging chemotherapeutic agents. We have also determined that the transcription factor MyoD, known to control the differentiation process, also plays a role in these apoptotic processes by directly increasing the expression of PUMA mRNA. Herein, we report an increase in PUMA protein …
Role In Recombination Of Genes That Control Meiotic Cell Divisions, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Role In Recombination Of Genes That Control Meiotic Cell Divisions, Francisco Monge, Jesus Monge, Andrew Reville, Rima Sandhu
Undergraduate Research Posters 2015
The production of gametes in Saccharomyces cerevisiae via meiosis is under strict regulatory control where proper segregation of homologous chromosomes into gametes requires physical linkage via crossovers. Cells that initiate meiotic recombination but do not process programmed double strand breaks into crossovers enter meiotic arrest. The main goal of the current project was whether overexpression of gene Y is sufficient to bypass the meiotic arrest in prophase I exhibited by dmc1 deletion and a zip1 mutant that carries an internal deletion. DMC1 is a recombinase that promotes homologous recombination. ZIP1 is a transverse filament protein of the synaptonemal complex (the …
The Effect Of Depression Symptoms On The Cardiac Autonomic Response To Positive Mood Induction, Elizabeth Golias, Khadeja Najjar, Brock Bodenbender
The Effect Of Depression Symptoms On The Cardiac Autonomic Response To Positive Mood Induction, Elizabeth Golias, Khadeja Najjar, Brock Bodenbender
Undergraduate Research Posters 2015
Depression is characterized by a reduced capacity to experience pleasure (hedonic capacity). A growing literature suggests that hedonic capacity is supported by the sympathetic (SNS) and parasympathetic (PNS) branches of the autonomic nervous system. Both branches may work in a reciprocal fashion, or in tandem, reflecting co-activation of the SNS and PNS. While reduced PNS and increased SNS activity are associated with happy states among healthy individuals, preliminary findings suggest that depressed persons evidence blunted physiologic responses across a variety of emotion inducing stimuli. Much of this work, however, has examined PNS and SNS activity separately, and never with respect …