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The Effects Of Pentazocine And Tripelennamine On Analgesia And Locomotion, James Philip Cleary
The Effects Of Pentazocine And Tripelennamine On Analgesia And Locomotion, James Philip Cleary
Dissertations
The effects of pentazocine and tripelennamine, alone and in combination, were assessed on measures of analgesia (hot plate test) and locomotion (open field) in rats and mice. In Experiment 1, the combination of pentazocine and tripelennamine was found to produce analgesia at doses which were not analgesic when the drugs were given alone. This combination also reestablished analgesia in subjects made tolerant to pentazocine's effects. In Experiment 2, development of tolerance to the analgesic effects of pentazocine was delayed by addition of tripelennamine. In Experiment 3, locomotion was decreased by pentazocine at the highest dose. A similar reduction was produced …
Analogues Of Steffimycinone, David Wayne Elrod
Analogues Of Steffimycinone, David Wayne Elrod
Masters Theses
Several analogues of Steffimycinone - an anthracycline antitumor antibiotic - have been prepared. Modifications were made at C-7 and C-10 of the non-aromatic A ring portion of the anthracycline nucleus. Compounds with nitrogen substituents were prepared. The synthesis of these compounds is discussed as well as their antitumor activity. The unsuccessful approaches to several other analogues are also discussed.