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Articles 1 - 30 of 52
Full-Text Articles in Life Sciences
Neurological-Type Wilson Disease: Epidemiology, Clinical Manifestations, Diagnosis, And Management, Nathaniel Kipker, Kaitlyn Alessi, Marko Bojkovic, Inderbir Padda, Mayur S. Parmar
Neurological-Type Wilson Disease: Epidemiology, Clinical Manifestations, Diagnosis, And Management, Nathaniel Kipker, Kaitlyn Alessi, Marko Bojkovic, Inderbir Padda, Mayur S. Parmar
HPD Articles
Wilson disease (WD) is a complex metabolic disorder caused by disruptions to copper regulation within the body, leading to an unregulated accumulation of copper within various tissues. A less understood organ affected by the collection of copper is the brain, which further leads to the generation of oxygen-free radicals and resultant demyelination. Healthcare providers must keep the neurological form of WD in their list of differentials when patients present with diverse neurological manifestations. The initial step to diagnosis will be to distinguish the characteristic disease presentation with a thorough history and physical and neurological examination. A high clinical disease suspicion …
Abaloparatide, Miis Akel, Mayur Parmar
Bazedoxifene, Parth M. Raina, Mayur Parmar
Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo
Romosozumab, Kristina Krupa, Mayur Parmar, Linda F. Delo
HPD Articles
No abstract provided.
A Case Of Transverse Myelitis Secondary To Covid-19 Infection, Rahul Borra, Neal T. Patel, Raheel Shaikh, Mayur S. Parmar, Sujatha Borra
A Case Of Transverse Myelitis Secondary To Covid-19 Infection, Rahul Borra, Neal T. Patel, Raheel Shaikh, Mayur S. Parmar, Sujatha Borra
HPD Articles
Infection with COVID-19 (SARS-CoV-2) is associated with a variety of generalized and specific symptoms, including neurological complications of both the peripheral and central nervous systems. In this case report, we present the case of a previously healthy 55-year-old woman who was diagnosed with transverse myelitis following a previous infection with COVID-19. MRI showed progressive demyelination of the cervical and thoracic spinal cord, and cerebrospinal fluid (CSF) showed increased levels of protein and red blood cells and no markers of infection, including negative polymerase chain reaction (PCR) for COVID-19 antibodies. The patient was treated with a course of methylprednisolone, multiple treatments …
Poststroke Seizure And Epilepsy: A Review Of Incidence, Risk Factors, Diagnosis, Pathophysiology, And Pharmacological Therapies, Joseph Phan, Mario Ramos, Theodore Soares, Mayur S. Parmar
Poststroke Seizure And Epilepsy: A Review Of Incidence, Risk Factors, Diagnosis, Pathophysiology, And Pharmacological Therapies, Joseph Phan, Mario Ramos, Theodore Soares, Mayur S. Parmar
HPD Articles
Stroke is the most common cause of epilepsy and ultimately leads to a decrease in the quality of life of those affected. Ischemic and hemorrhagic strokes can both lead to poststroke epilepsy (PSE). Significant risk factors for PSE include age less than 65 years, stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS), cortical involvement, and genetic factors such as TRPM6 polymorphism. The diagnosis of PSE is made by using imaging modalities, blood biomarkers, and prognostic criteria. Electroencephalography (EEG) is currently the gold standard to diagnose PSE, while new combinations of modalities are being tested to increase …
Effects Of Covid-19 On Pregnant Women And Newborns: A Review, Bhavesh M. Patel, Deepesh Khanna, Siya Khanna, Vera Hapshy, Pragya Khanna, Payal Kahar, Mayur S. Parmar
Effects Of Covid-19 On Pregnant Women And Newborns: A Review, Bhavesh M. Patel, Deepesh Khanna, Siya Khanna, Vera Hapshy, Pragya Khanna, Payal Kahar, Mayur S. Parmar
HPD Articles
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus originated in Wuhan, China, and spread all over the world, causing the worst pandemic of the century. The disease has a broad continuum of clinical presentations, from mild to life-threatening. The virus is highly contagious and transmittable to humans. Emerging evidence of its effects on pregnant women and newborns is inconsistent and ever-evolving. Therefore, the objective of this review is to compile the scientific literature on the effects of SARS-CoV-2 coronavirus on pregnancy, pregnant women, and newborns. Data were obtained by several authors using PubMed, MEDLINE, Google Scholar, and Web …
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna
A Review Of Covid-19 In Relation To Metabolic Syndrome: Obesity, Hypertension, Diabetes, And Dyslipidemia, Elias Makhoul, Joseph L. Aklinski, Jesse Miller, Cara Leonard, Sean Backer, Payal Kahar, Mayur S. Parmar, Deepesh Khanna
HPD Articles
Although severe cases and mortality of coronavirus disease 2019 (COVID-19) are proportionally infrequent, these cases are strongly linked to patients with conditions of metabolic syndrome (obesity, hypertension, diabetes, and dyslipidemia). However, the pathophysiology of COVID-19 in relation to metabolic syndrome is not well understood. Thus, the goal of this secondary literature review was to examine the relationship between severe acute respiratory syndrome (SARS-CoV-2) infection and the individual conditions of metabolic syndrome. The objective of this secondary literature review was achieved by examining primary studies, case studies, and other secondary studies, to obtain a comprehensive perspective of theories and observations of …
Body Mass Index (Bmi): A Screening Tool Analysis, Deepesh Khanna, Cadynce Peltzer, Payal Kahar, Mayur S. Parmar
Body Mass Index (Bmi): A Screening Tool Analysis, Deepesh Khanna, Cadynce Peltzer, Payal Kahar, Mayur S. Parmar
HPD Articles
Body mass index (BMI), a measurement based on a person's height and weight, allows the classification of individuals into categories such as obese or overweight. With these classifications, we can assess risk for hypertension, diabetes, cancer, hypercholesterolemia, and other chronic diseases. Furthermore, childhood BMI serves as a prediction method for health and disease later in life. Along with BMI, researchers also study waist circumference and waist-to-hip ratio in correlation with the above-mentioned chronic illnesses. This brief review explores the associations between body mass index, waist circumference, and the waist-hip ratio as measurements and their capability as predictors for persistent conditions …
Small Interfering Rna (Sirna)-Based Therapy, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
Small Interfering Rna (Sirna)-Based Therapy, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
HPD Articles
No abstract provided.
Golimumab, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Golimumab, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Sodium-Glucose Transport Protein 2 (Sglt2) Inhibitors, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
Sodium-Glucose Transport Protein 2 (Sglt2) Inhibitors, Inderbir S. Padda, Arun U. Mahtani, Mayur S. Parmar
HPD Articles
No abstract provided.
Poststroke Seizure And Epilepsy: A Review Of Incidence, Risk Factors, Diagnosis, Pathophysiology, And Pharmacological Therapies, Joseph Phan, Mario Ramos, Theodore Soares, Mayur S. Parmar
Poststroke Seizure And Epilepsy: A Review Of Incidence, Risk Factors, Diagnosis, Pathophysiology, And Pharmacological Therapies, Joseph Phan, Mario Ramos, Theodore Soares, Mayur S. Parmar
HPD Articles
Stroke is the most common cause of epilepsy and ultimately leads to a decrease in the quality of life of those affected. Ischemic and hemorrhagic strokes can both lead to poststroke epilepsy (PSE). Significant risk factors for PSE include age < 65age less than 65 years, stroke severity measured by the National Institutes of Health Stroke Scale (NIHSS), cortical involvement, and genetic factors such as TRPM6 polymorphism. The diagnosis of PSE is made by using imaging modalities, blood biomarkers, and prognostic criteria. Electroencephalography (EEG) is currently the gold standard to diagnose PSE, while new combinations of modalities are being tested to increase diagnostic specificity. This literature review uncovers a newly found mechanism for the pathology of poststroke epilepsy. The pathogenesis of early-onset and late-onset is characterized by sequelae of neuronal cellular hypoxia and disruption of the blood-brain barrier, respectively. Interleukin-6 is responsible for increasing the activity of glial cells, causing gliosis and hyperexcitability of neurons. Epinephrine, high-mobility group protein B1, downregulation of CD32, and upregulation of HLA-DR impact the pathology of poststroke epilepsy by inhibiting the normal neuronal immune response. Decreased levels of neuropeptide Y, a neurotransmitter, act through multiple unique mechanisms, such as inhibiting intracellular Ca accumulation and acting as an anti-inflammatory, also implemented in the worsening progression of poststroke epilepsy. Additionally, CA1 hippocampal resonant neurons that increase theta oscillation are associated with poststroke epilepsy. Hypertensive small vessel disease may also have an implication in the temporal lobe epilepsy by causing occult microinfarctions. Furthermore, this review highlights the potential use of statins as primary prophylaxis against PSE, with multiple studies demonstrating a reduction in incidence using statins alone, statins in combination with antiepileptic drugs (AEDs), and statins with aspirin. The evidence strongly suggests that the second generation AEDs are a superior treatment method for PSE. Data from numerous studies demonstrate their relative lack of significant drug interactions, increased tolerability, and potential superiority in maintaining seizure-free status.
The Link Between Diabetes Mellitus And Tau Hyperphosphorylation: Implications For Risk Of Alzheimer's Disease, Amy L. Hobday, Mayur S. Parmar
The Link Between Diabetes Mellitus And Tau Hyperphosphorylation: Implications For Risk Of Alzheimer's Disease, Amy L. Hobday, Mayur S. Parmar
HPD Articles
Diabetes mellitus (DM) is characterized by hyperglycemia caused by a lack of insulin, insulin resistance, or both. It is associated with the development of secondary complications resulting in several comorbidities. Recent studies have revealed an increased risk of developing cognitive dysfunction or dementia in diabetes patients. Diabetes mellitus is considered a risk factor for many neurodegenerative diseases, including Alzheimer's disease (AD). There is increasing evidence to support a link between DM and AD. Studies have shown the dysfunction of insulin signaling in the brain, resulting in increased tau protein phosphorylation (hyperphosphorylation), a hallmark and biomarker of AD pathology, leading to …
Epidemiology, Pathogenesis, And Clinical Manifestations Of Acute Esophageal Necrosis In Adults, Obaid Rehman, Urooj Jaferi, Inderbir Padda, Nimrat Khehra, Harshan Atwal, Mayur Parmar
Epidemiology, Pathogenesis, And Clinical Manifestations Of Acute Esophageal Necrosis In Adults, Obaid Rehman, Urooj Jaferi, Inderbir Padda, Nimrat Khehra, Harshan Atwal, Mayur Parmar
HPD Articles
Acute esophageal necrosis (AEN), also termed "black esophagus," is a unique and uncommon occurrence observed in severely sick patients. Other terminologies include acute necrotizing esophagitis and Gurvits syndrome. This condition is described as a darkened distal third of the esophagus observed on endoscopy and presents as an upper gastrointestinal (GI) bleed, difficulty swallowing, abdominal pain, fever, syncope, nausea, and vomiting. The etiology of AEN has been linked to several possibilities, such as excessive gastric acid reflux, hypoperfusion, and ischemia due to impaired vascular supply and hemodynamic instability. Risk factors include increased age, sex (male), heart disease, hemodynamic insufficiency, alcohol use, …
Biosimilars Use In Medicine For Inflammatory Diseases, Inderbir S. Padda, Rajat Bhatt, Obaid Rehman, Mayur S. Parmar
Biosimilars Use In Medicine For Inflammatory Diseases, Inderbir S. Padda, Rajat Bhatt, Obaid Rehman, Mayur S. Parmar
HPD Articles
No abstract provided.
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
Covid (Sars-Cov-2) Vaccine, Inderbir S. Padda, Mayur S. Parmar
HPD Articles
No abstract provided.
Aducanumab, Inderbir S. Padda, Mayur S. Parmar
Apremilast, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Apremilast, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Pegloticase, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Pegloticase, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Tofacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Tofacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Upadacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
Upadacitinib, Inderbir S. Padda, Rajat Bhatt, Mayur S. Parmar
HPD Articles
No abstract provided.
Lenvatinib, Inderbir S. Padda, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
Obeticholic Acid, Kristina Krupa, Vera Hapshy, Hiep Nguyen, Mayur S. Parmar
HPD Articles
No abstract provided.
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
Human Papilloma Virus Vaccine, Lucia Soca Gallego, Alvio Dominguez, Mayur S. Parmar
HPD Articles
No abstract provided.
Flucytosine, Inderbir S. Padda, Mayur S. Parmar
Reserpine, Michelle Cheung, Mayur S. Parmar
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
Omega-3 Fatty Acids, Kristina Krupa, Kristina Fritz, Mayur S. Parmar
HPD Articles
No abstract provided.
Iron Dextran, Sebastiano Failla, Mayur S. Parmar
Lisinopril, Edgardo Olvera Lopez, Mayur S. Parmar, Venkata Satish Pendela, Jamie M. Terrell
Lisinopril, Edgardo Olvera Lopez, Mayur S. Parmar, Venkata Satish Pendela, Jamie M. Terrell
HPD Articles
No abstract provided.