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Articles 1 - 18 of 18
Full-Text Articles in Life Sciences
Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer
Jennifer Maurer Phd Thesis.Pdf, Jennifer Maurer
Jennifer Maurer
Rumination Is Associated With Diminished Performance Monitoring, Ema Tanovic, Greg Hajack, Charles A. Sanislow
Rumination Is Associated With Diminished Performance Monitoring, Ema Tanovic, Greg Hajack, Charles A. Sanislow
Charles A. Sanislow, Ph.D.
The Effects Of Ethanol On Diverse Components Of Choice In The Rat: Reward Discrimination, Preference And Relative Valuation, Howard C. Cromwell, Justin J. Mcgraw, Luke Zona
The Effects Of Ethanol On Diverse Components Of Choice In The Rat: Reward Discrimination, Preference And Relative Valuation, Howard C. Cromwell, Justin J. Mcgraw, Luke Zona
Howard Casey Cromwell
High-Fat Diet Increases Pain Behaviors In Rats With Or Without Obesity.Pdf, Sisi Chen
High-Fat Diet Increases Pain Behaviors In Rats With Or Without Obesity.Pdf, Sisi Chen
SISI CHEN
No abstract provided.
Microarray Analysis Of Aging-Associated Immune System Alterations In The Rostral Ventrolateral Medulla Of F344 Rats, Sivasai Balivada, Chanran K. Ganta, Yongqing Zhang, Hitesh N. Pawar, Richard J. Ortiz, Kevin G. Becker, Arshad M. Khan, Michael J. Kenney
Microarray Analysis Of Aging-Associated Immune System Alterations In The Rostral Ventrolateral Medulla Of F344 Rats, Sivasai Balivada, Chanran K. Ganta, Yongqing Zhang, Hitesh N. Pawar, Richard J. Ortiz, Kevin G. Becker, Arshad M. Khan, Michael J. Kenney
Arshad M. Khan, Ph.D.
Effects Of Anandamide Administration On Components Of Reward Processing, Howard C. Cromwell
Effects Of Anandamide Administration On Components Of Reward Processing, Howard C. Cromwell
Howard Casey Cromwell
Why Animal Welfarism Continues To Fail, Lori Marino
Why Animal Welfarism Continues To Fail, Lori Marino
Lori Marino, PhD
Welfarism prioritizes human interests over the needs of nonhuman animals. Despite decades of welfare efforts other animals are mostly worse off than ever before, being subjected to increasingly invasive and harmful treatments, especially in the factory farming and biomedical research areas. A legal rights-based approach is essential in order for other animals to be protected from the varying ethical whims of our species.
Discovery Of Thienoquinolone Derivatives As Selective And Atp Non-Competitive Cdk5/P25 Inhibitors By Structure-Based Virtual Screening, Arindam Chatterjee, Stephen J. Cutler, Robert J. Doerksen, Ikhlas A. Khan, John S. Williamson
Discovery Of Thienoquinolone Derivatives As Selective And Atp Non-Competitive Cdk5/P25 Inhibitors By Structure-Based Virtual Screening, Arindam Chatterjee, Stephen J. Cutler, Robert J. Doerksen, Ikhlas A. Khan, John S. Williamson
John S. Williamson
Calpain mediated cleavage of CDK5 natural precursor p35 causes a stable complex formation of CDK5/p25, which leads to hyperphosphorylation of tau. Thus inhibition of this complex is a viable target for numerous acute and chronic neurodegenerative diseases involving tau protein, including Alzheimer’s disease. Since CDK5 has the highest sequence homology with its mitotic counterpart CDK2, our primary goal was to design selective CDK5/p25 inhibitors targeting neurodegeneration. A novel structure-based virtual screening protocol comprised of e-pharmacophore models and virtual screening workflow was used to identify nine compounds from a commercial database containing 2.84 million compounds. An ATP non-competitive and selective thieno[3,2- …
Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore
Multi-Scale Motility Amplitude Associated With Suicidal Thoughts In Major Depression, Premananda Indic, Greg Murray, Carlo Maggini, Mario Amore, Tiziana Meschi, Loris Borghi, Ross J. Baldessarini, Paola Salvatore
Premananda Indic
Major depression occurs at high prevalence in the general population, often starts in juvenile years, recurs over a lifetime, and is strongly associated with disability and suicide. Searches for biological markers in depression may have been hindered by assuming that depression is a unitary and relatively homogeneous disorder, mainly of mood, rather than addressing particular, clinically crucial features or diagnostic subtypes. Many studies have implicated quantitative alterations of motility rhythms in depressed human subjects. Since a candidate feature of great public-health significance is the unusually high risk of suicidal behavior in depressive disorders, we studied correlations between a measure (vulnerability …
Casein Kinase 1 Delta (Ck1delta) Regulates Period Length Of The Mouse Suprachiasmatic Circadian Clock In Vitro, Jean-Pierre Etchegaray, Elizabeth A. Yu, Premananda Indic, Robert Dallmann, David R. Weaver
Casein Kinase 1 Delta (Ck1delta) Regulates Period Length Of The Mouse Suprachiasmatic Circadian Clock In Vitro, Jean-Pierre Etchegaray, Elizabeth A. Yu, Premananda Indic, Robert Dallmann, David R. Weaver
Premananda Indic
BACKGROUND: Casein kinase 1 delta (CK1delta) plays a more prominent role in the regulation of circadian cycle length than its homologue casein kinase 1 epsilon (CK1epsilon) in peripheral tissues such as liver and embryonic fibroblasts. Mice lacking CK1delta die shortly after birth, so it has not been possible to assess the impact of loss of CK1delta on behavioral rhythms controlled by the master circadian oscillator in the suprachiasmatic nuclei (SCN).
METHODOLOGY/PRINCIPAL FINDINGS: In the present study, mPER2::LUCIFERASE bioluminescence rhythms were monitored from SCN explants collected from neonatal mice. The data demonstrate that SCN explants from neonatal CK1delta-deficient mice oscillate, but …
Experimental Exposure To Urban And Pink Noise Affects Brain Development And Song Learning In Zebra Finches (Taenopygia Guttata), Dominique A. Potvin, Michael T. Curcio, John P. Swaddle, Scott A. Macdougall-Shackleton
Experimental Exposure To Urban And Pink Noise Affects Brain Development And Song Learning In Zebra Finches (Taenopygia Guttata), Dominique A. Potvin, Michael T. Curcio, John P. Swaddle, Scott A. Macdougall-Shackleton
John Swaddle
Recently, numerous studies have observed changes in bird vocalizations—especially song—in urban habitats. These changes are often interpreted as adaptive, since they increase the active space of the signal in its environment. However, the proximate mechanisms driving cross-generational changes in song are still unknown. We performed a captive experiment to identify whether noise experienced during development affects song learning and the development of song-control brain regions. Zebra finches (Taeniopygia guttata) were bred while exposed, or not exposed, to recorded traffic urban noise (Study 1) or pink noise (Study 2). We recorded the songs of male offspring and compared these to fathers’ …
Antagonistic Serotonergic And Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior In Caenorhabditis Elegans, Matthew A. Churgin, Richard J. Mccloskey, Emily Peters, Christopher Fang-Yen
Antagonistic Serotonergic And Octopaminergic Neural Circuits Mediate Food-Dependent Locomotory Behavior In Caenorhabditis Elegans, Matthew A. Churgin, Richard J. Mccloskey, Emily Peters, Christopher Fang-Yen
Christopher Fang-Yen
No abstract provided.
Comparing Caenorhabditis Elegans Gentle And Harsh Touch Response Behavior Using A Multiplexed Hydraulic Microfluidic Device, Patrick D. Mcclanahan, Joyce Xu, Christopher Fang-Yen
Comparing Caenorhabditis Elegans Gentle And Harsh Touch Response Behavior Using A Multiplexed Hydraulic Microfluidic Device, Patrick D. Mcclanahan, Joyce Xu, Christopher Fang-Yen
Christopher Fang-Yen
Food Responsiveness Regulates Episodic Behavioral States In Caenorhabditis Elegans, Richard J. Mccloskey, Anthony D. Fouad, Matthew A. Churgin, Christopher Fang-Yen
Food Responsiveness Regulates Episodic Behavioral States In Caenorhabditis Elegans, Richard J. Mccloskey, Anthony D. Fouad, Matthew A. Churgin, Christopher Fang-Yen
Christopher Fang-Yen
Sensory Neurons Co-Opt Classical Immune Signaling Pathways To Mediate Chronic Itch.Pdf, Sisi Chen
Sensory Neurons Co-Opt Classical Immune Signaling Pathways To Mediate Chronic Itch.Pdf, Sisi Chen
SISI CHEN
No abstract provided.
Sciatic Endometriosis Induces Mechanical Hypersensitivity,.Pdf, Sisi Chen
Sciatic Endometriosis Induces Mechanical Hypersensitivity,.Pdf, Sisi Chen
SISI CHEN
No abstract provided.
Neurobiology Of The Premonitory Urge In Tourette's Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon
Neurobiology Of The Premonitory Urge In Tourette's Syndrome: Pathophysiology And Treatment Implications, Andrea E. Cavanna, Kevin J. Black, Mark Hallett, Valerie Voon
Kevin J. Black, MD
Whole Genome Dna Methylation Sequencing Of The Chicken Retina, Cornea And Brain, Isac Lee, Bejan A. Rasoul, Ashton S. Holub, Alannah Lejeune, Raymond A. Enke, Winston Timp
Whole Genome Dna Methylation Sequencing Of The Chicken Retina, Cornea And Brain, Isac Lee, Bejan A. Rasoul, Ashton S. Holub, Alannah Lejeune, Raymond A. Enke, Winston Timp
Ray Enke Ph.D.
No abstract provided.