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Rat Hind Limb Nociceptive Withdrawal Response Depends On Initial Paw Position But Not Stimulus Location, Kimberly Seamon
Rat Hind Limb Nociceptive Withdrawal Response Depends On Initial Paw Position But Not Stimulus Location, Kimberly Seamon
Senior Honors Projects, 2010-2019
There have been numerous studies in non-human animals on the effect of stimulus location on the NWR and at least a few studies that address the role of initial posture. However, all of these studies were conducted in anesthetized, decerebrated, or spinalized mammals. Since descending modulation and long loop reflexes may influence the NWR, the anesthetized spinalized/decerebrated animal may not be an adequate model of normal animals. Therefore, the primary aim of this study was to determine the effect of the stimulus location and initial paw position on the direction and magnitude of the nociceptive withdrawal response to heat stimulus …