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The Effects Of Estrogen On Dorsal Root Ganglion Neurons, Sheila A. Scoville
The Effects Of Estrogen On Dorsal Root Ganglion Neurons, Sheila A. Scoville
Theses and Dissertations in Biomedical Sciences
Skin sensation is mediated by dorsal root ganglion (DRG) neurons. Data indicates that skin sensitivity in female rats is estrogen-dependent. Some DRG neurons have estrogen receptors (ERs) which are regulated by estrogen. In these cells, nerve growth factor (NGF) and estrogen receptors colocalize. Regulation of NGF receptors and neuronal sensitivity to NGF may allow estrogen to regulate NGF-dependent genes. The goals of the present study were to determine which DRG neurons express the ER gene and to analyze the effects of long-term estrogen administration on the interrelated expression of tyrosine kinase A (trkA), preprotachykinin (PPT), and 68kD neurofilament (NF) genes …