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A Rhizosphere Fungus Enhances Arabidopsis Thermotolerance Through Production Of An Hsp90 Inhibitor, Catherine A. Mclellan, Thomas J. Turbyville, E. M. Kithsiri Wijeratne, Arthur Kerschen, Elizabeth Vierling, Christine Queitsch, Luke Whitesell, A. A. Leslie Gunatilaka
A Rhizosphere Fungus Enhances Arabidopsis Thermotolerance Through Production Of An Hsp90 Inhibitor, Catherine A. Mclellan, Thomas J. Turbyville, E. M. Kithsiri Wijeratne, Arthur Kerschen, Elizabeth Vierling, Christine Queitsch, Luke Whitesell, A. A. Leslie Gunatilaka
Elizabeth Vierling
The molecular chaperone HEAT SHOCK PROTEIN90 (HSP90) is essential for the maturation of key regulatory proteins in eukaryotes and for the response to temperature stress. Earlier, we have reported that fungi living in association with plants of the Sonoran desert produce small molecule inhibitors of mammalian HSP90. Here, we address whether elaboration of the HSP90 inhibitor monocillin I (MON) by the rhizosphere fungus Paraphaeosphaeria quadriseptata affects plant HSP90 and plant environmental responsiveness. We demonstrate that MON binds Arabidopsis (Arabidopsis thaliana) HSP90 and can inhibit the function of HSP90 in lysates of wheat (Triticum aestivum) germ. MON treatment of Arabidopsis seedlings …