Open Access. Powered by Scholars. Published by Universities.®
- Institution
-
- The Texas Medical Center Library (36)
- Washington University in St. Louis (33)
- Western University (23)
- University of Arkansas, Fayetteville (22)
- University of Kentucky (21)
-
- City University of New York (CUNY) (17)
- University of Nebraska Medical Center (15)
- West Virginia University (12)
- University of South Florida (10)
- Virginia Commonwealth University (10)
- University of Central Florida (9)
- University of Nevada, Las Vegas (9)
- University of Vermont (8)
- Marshall University (7)
- Old Dominion University (7)
- Portland State University (7)
- Rowan University (7)
- Western Michigan University (7)
- Chapman University (6)
- Georgia Southern University (6)
- The University of Akron (6)
- University of Mississippi (6)
- University of Tennessee, Knoxville (6)
- University of Texas Rio Grande Valley (6)
- University of Windsor (6)
- Walden University (6)
- American University in Cairo (5)
- East Tennessee State University (5)
- Sarah Lawrence College (5)
- University of South Dakota (5)
- Keyword
-
- Cancer (20)
- Breast cancer (11)
- Aging (9)
- COVID-19 (7)
- Immunotherapy (7)
-
- Inflammation (7)
- Physical activity (7)
- Stress (7)
- Bioinformatics (6)
- Epigenetics (6)
- Exercise (6)
- Macrophages (6)
- Obesity (6)
- Alzheimer's Disease (5)
- Antibiotic resistance (5)
- FMRI (5)
- Genetics (5)
- HIV (5)
- Metastasis (5)
- Mitochondria (5)
- Neurodegeneration (5)
- Athlete (4)
- Breast Cancer (4)
- Chronic (4)
- Cognition (4)
- Diabetes (4)
- Fatigue (4)
- Genetic counseling (4)
- Glioblastoma (4)
- Heart (4)
- Publication
-
- Dissertations & Theses (Open Access) (36)
- Arts & Sciences Electronic Theses and Dissertations (32)
- Theses and Dissertations (31)
- Electronic Theses and Dissertations (23)
- Electronic Thesis and Dissertation Repository (23)
-
- Honors Theses (16)
- Graduate Theses and Dissertations (14)
- Theses & Dissertations (14)
- Graduate Theses, Dissertations, and Problem Reports (12)
- Dissertations, Theses, and Capstone Projects (11)
- USF Tampa Graduate Theses and Dissertations (10)
- UNLV Theses, Dissertations, Professional Papers, and Capstones (9)
- Honors College Theses (8)
- Honors Undergraduate Theses (7)
- Theses, Dissertations and Capstones (7)
- University Honors Theses (7)
- Dissertations (6)
- Graduate College Dissertations and Theses (6)
- Graduate School of Biomedical Sciences Theses and Dissertations (6)
- Walden Dissertations and Doctoral Studies (6)
- Williams Honors College, Honors Research Projects (6)
- Dissertations and Theses (5)
- Honors Projects (5)
- Honors Thesis (5)
- Human Genetics Theses (5)
- Open Access Theses & Dissertations (5)
- Theses (5)
- Doctoral Dissertations (4)
- Masters Theses (4)
- Pharmaceutical Sciences (PhD) Dissertations (4)
Articles 451 - 464 of 464
Full-Text Articles in Life Sciences
Impact Of Hemodynamic Vortex Spatial And Temporal Characteristics On Analysis Of Intracranial Aneurysms, Kevin W. Sunderland
Impact Of Hemodynamic Vortex Spatial And Temporal Characteristics On Analysis Of Intracranial Aneurysms, Kevin W. Sunderland
Dissertations, Master's Theses and Master's Reports
Subarachnoid hemorrhage is a potentially devastating pathological condition in which bleeding occurs into the space surrounding the brain. One of the prominent sources of subarachnoid hemorrhage are intracranial aneurysms (IA): degenerative, irregular expansions of area(s) of the cerebral vasculature. In the event of IA rupture, the resultant subarachnoid hemorrhage ends in patient mortality occurring in ~50% of cases, with survivors enduring significant neurological damage with physical or cognitive impairment. The seriousness of IA rupture drives a degree of clinical interest in understanding these conditions that promote both the development and possible rupture of the vascular malformations. Current metrics for the …
The Impact Of Combined Flexion And Compression On The Mechanical Integrity Of The Annulus Fibrosus, Keaton Briar
The Impact Of Combined Flexion And Compression On The Mechanical Integrity Of The Annulus Fibrosus, Keaton Briar
Theses and Dissertations (Comprehensive)
Introduction: Intervertebral disc (IVD) herniation is characterized by an expulsion of nucleus pulposus (NP) material through the annulus fibrosus (AF). The AF contains two major adhesive structures, the intralamellar matrix and the interlamellar matrix, which act to maintain the strength of the AF and prevent NP material migration. As a herniation occurs, clefts form within the intralamellar matrix, pushing the NP between adjacent collagen fibres; meanwhile, delamination of the interlamellar matrix causes the NP to pool between layers of the AF. Further, herniation more readily occurs in a combined loading scenario of both compression and flexion. Flexion, and in particular …
Pushing The Limits: Increasing The Speed And Specificity Of Sars-Cov-2 Testing, Grayson Way
Pushing The Limits: Increasing The Speed And Specificity Of Sars-Cov-2 Testing, Grayson Way
Theses and Dissertations
The prevalence and spread of the current COVID-19 pandemic have highlighted the importance of continual improvements upon current microbiological testing methods. Rapid and accurate testing can help mitigate spread by improving on the time to quarantine and quarantine duration required. As of the writing of this thesis, COVID-19 has been responsible for more than 500,000 deaths in the United States of America, and greater than 2 million deaths globally. The work done in this thesis has shown improvements in the current SARS-CoV-2 testing methodology by reducing the time it takes for patient testing while maintaining accuracy and the sensitivity required …
Influence Of Metal Sleeves In The Accuracy Of Dental Implant Placement Using Guided Implant Surgery, Coleman Adams
Influence Of Metal Sleeves In The Accuracy Of Dental Implant Placement Using Guided Implant Surgery, Coleman Adams
Theses and Dissertations
The fabrication of implant surgical guides through stereolithographic 3D printing has become a staple in dental implant guided surgery over the last couple decades. These surgical guides have typically utilized metal sleeves to assist in guidance of the drills during osteotome preparation. The metal sleeves can be costly and potentially cause deviations if improperly placed during post-processing of the guide. This research explored a novel method for the utilization of sleeve-free surgical guides by comparing the dimensional and angulational deviations between the implant guides with and without a metal sleeve. To achieve this goal, two separate aims were pursued. Our …
A Novel Review Of Heat Shock Protein 110 Kda: A Basis For Research And Continued Experimentation Through Biochemical Analysis, Crist W. Cuffee
A Novel Review Of Heat Shock Protein 110 Kda: A Basis For Research And Continued Experimentation Through Biochemical Analysis, Crist W. Cuffee
Theses and Dissertations
Heat shock protein 110 kDa, Hsp110, is a distinct cellular protector, different in form and function from Hsp70, a close relative of Hsp110. Functioning primarily as a holdase or in tandem with other molecular chaperones, a review of current accomplishments elucidates the uniqueness of this protein and the continued mysteries that surrounds it. Found only in eukaryotes, Hsp110 has been linked to many diseases, ranging from parasitic infection to neurodegenerative disorders. While still lacking, studies of this protein have provided much in the realm of speculation on the mechanisms behind Hsp110s’ contribution to different pathologies. This review will serve as …
A Novel Immunostimulatory Platform For Amplifying The Abscopal Response Rates Of Radiation Therapy, Patrick A. Paez
A Novel Immunostimulatory Platform For Amplifying The Abscopal Response Rates Of Radiation Therapy, Patrick A. Paez
Theses and Dissertations
Radiation therapy (RT) is one of the primary treatment modalities for head and neck squamous cell carcinoma (HNSCC). At the time of diagnosis two-thirds of HNSCC patients have local-advanced disease and 50-60% of these patients will experience a local-regional or metastatic relapse within three years. Improving the immunogenic response of RT may help address this clinical problem. However, current RT regimens have failed to reliably generate robust antitumor immunity as evidenced by the rarity of clinical abscopal responses. Recently we engineered a chimeric fusion molecule called Flagrp170, a novel immunostimulatory agent highly capable of promoting antigen presentation and T-cell activation. …
Investigating Cannabinoid Type-1 Receptor (Cb1r) Positive Allosteric Modulators (Pams) In Mouse Models Of Overt Cannabimimetic Activity, Subjective Drug Effects, And Neuropathic Pain, Jayden Elmer
Theses and Dissertations
Chronic pain affects between 20 and 30 percent of the adult population in western countries and represents a wide array of specific etiologies (Berge, 2011). Neuropathic pain secondary to traumatic nerve injury, chemotherapeutic toxicity, or diseases (e.g., diabetes mellitus) is often refractory to conventional analgesics, with patients receiving less than 50% pain relief compared to placebo (Finnerup et al. 2010). The endocannabinoid system has shown potential as a therapeutic target for neuropathic pain wherein CB1 agonism via administration of exogenous agonists or pharmacological blockade of endocannabinoid catabolic enzymes exhibits efficacy in reversing allodynia in the chronic constriction injury (CCI) model …
Impact Of Targeting Glycosylated Ceramides On Tumorigenic Properties, And Characterization Of Sphingolipids In Head And Neck Tumors, Katherine E. Hylton
Impact Of Targeting Glycosylated Ceramides On Tumorigenic Properties, And Characterization Of Sphingolipids In Head And Neck Tumors, Katherine E. Hylton
Theses and Dissertations
Sphingolipids play a crucial role in signaling, membrane structure, and migration, making them important molecules in cancer development, metastasis, and drug resistance. While some sphingolipids have been associated with pro-apoptotic or pro-survival behaviors, the role of many sphingolipids in cancer remains poorly defined. Chapter 1 of this study investigated the impact of three enzymes that compose most of the ceramide to Lc3 ceramide pathway – UGCG, GBA, and B3GNT5 – and how their alteration impacts chemoresistance and basal membrane invasion in vitro. It was found that the CΒE-induced inhibition of GBA, which converts glucosylceramide to ceramide, has no effects on …
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Nebulizer-Based Systems To Improve Pharmaceutical Aerosol Delivery To The Lungs, Benjamin M. Spence
Theses and Dissertations
Combining vibrating mesh nebulizers with additional new technologies leads to substantial improvements in pharmaceutical aerosol delivery to the lungs across therapeutic administration methods. In this dissertation, streamlined components, aerosol administration synchronization, and/or Excipient Enhanced Growth (EEG) technologies were utilized to develop and test several novel devices and aerosol delivery systems. The first focus of this work was to improve the poor delivery efficiency, e.g., 3.6% of nominal dose (Dugernier et al. 2017), of aerosolized medication administration to adult human subjects concurrent with high flow nasal cannula (HFNC) therapy, a form of continuous-flow non-invasive ventilation (NIV). The developed Low-Volume Mixer-Heater (LVMH) …
Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin
Science-Based Regulation Of Pharmacological Substances In Competition Horses, Jacob Machin
Theses and Dissertations--Toxicology and Cancer Biology
Current testing methodologies within equine forensic toxicology focus on arbitrary thresholds and zero-tolerance policy. Modern analytical chemistry’s limits of detection are low enough that oftentimes femtogram-per-milliliter amounts of a substance can readily be identified in both blood and urine of a horse. For most pharmacologically relevant compounds, these concentrations have no relevance to pharmacological effect. It is therefore crucial that testing methodologies to determine appropriate thresholds and cut-offs be developed that are driven by biological activity rather than arbitrary limits of detection. This dissertation looks to address this by suggesting a system of calculated Effective Plasma Concentrations by which a …
Examination Of Sex- And Intensity-Specific Fatigue During Bilateral Leg Extension Exercise, Taylor Kayln Dinyer
Examination Of Sex- And Intensity-Specific Fatigue During Bilateral Leg Extension Exercise, Taylor Kayln Dinyer
Theses and Dissertations--Kinesiology and Health Promotion
The purposes of this study were to: 1) examine sex-related differences in the performance of repetitions to failure below (CL-10%, CL-20%) and above (50%, 60%, 70%, and 80% 1RM) the critical load (CL) to make inferences regarding the mechanisms responsible for variability in the performance of repetitions to failure at varying loads; 2) examine the time course of neuromuscular and muscle oxygen saturation responses during the performance of repetitions to failure below and above the CL; 3) to make inferences regarding motor unit activation strategies used to maintain force during the completion of repetitions below and …
Examination Of Sex- And Limb-Specific Fatigue During Unilateral, Isometric Forearm Exercise, Caleb Christian Voskuil
Examination Of Sex- And Limb-Specific Fatigue During Unilateral, Isometric Forearm Exercise, Caleb Christian Voskuil
Theses and Dissertations--Kinesiology and Health Promotion
The purpose of this study was to examine the effects of unilateral, isometric handgrip holds to failure for the dominant (Dm) and non-dominant (NDm) limb on ipsilateral ([IPS] exercised side) and contralateral ([CON] non-exercised side) performance fatigability. Twenty individuals participated in this study (Men [n =10]; Women [n = 10; Composite Demographics: Age: 22.2 years; Height: 174.4 cm; Body Mass: 75.0 kg) and completed three visits. Two, 6 s maximal voluntary isometric contractions (MVICs) for the Dm and NDm limb were performed during visit 1, followed by a familiarization of the fatigue test. Visits 2 and 3 included an isometric, …
Development Of Aptamer Rolling Circle Amplification Platform As A Vaccine Adjuvant To Control Salmonella In Broiler Chickens, Abigeal Iyabode Omolewu
Development Of Aptamer Rolling Circle Amplification Platform As A Vaccine Adjuvant To Control Salmonella In Broiler Chickens, Abigeal Iyabode Omolewu
Graduate Theses and Dissertations
Salmonella has been a major source of concern in public health and food industry. It is the cause of gastrointestinal illness and fever called salmonellosis. Severe cases of salmonellosis have resulted in hospitalization and even death around the world. Salmonella can be found in the intestinal tract of animals including chickens and can be transmitted to human through contaminated food. Hence, it is highly important to find ways of reducing the transmission of Salmonella from chickens to humans. This work is focused on the control of Salmonella in broiler chicken through the development of novel vaccine adjuvant. Two different aptamer …
Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding
Defining The Potential Of Gene Therapy With Bone Morphogenetic Proteins As A Novel Therapeutic Approach In Parkinson’S Disease, Susan Rebecca Goulding
Theses
Parkinson’s disease is a neurodegenerative disorder, characterised by the progressive degeneration of midbrain dopaminergic neurons, and the intracellular aggregation of the α-synuclein protein in neurons throughout the nervous system. These changes result in the characteristic motor impairments in Parkinson’s disease. Current treatments are solely symptomatic and therefore there is an unmet clinical need to develop new disease-modifying therapies that can alter disease progression. For over 25 years, one proposed experimental therapy has focused on the delivery of proteins called neurotrophic factors to the brain to prevent dopaminergic neuron degeneration. However, to date, clinical trials using the most well-known neurotrophic factors …