Life Sciences Commons^™

Designer Biologics Composed Of Hepatocyte Growth Factor, Fibroblast Growth Factor 2 And Immunoglobulin G For Treatment Of Acute Myocardial Infarction, Benjamin Liebman

Graduate College Dissertations and Theses

ABSTRACT Coronary artery disease leading to myocardial infarction (a.k.a. MI, heart attack) is one of the leading causes of death globally. Each year an estimated 605,000 Americans suffer a heart attack, which equates to one MI every 40 seconds. As such, MI represents one of the largest health burdens to society. The current standard of care is revascularization therapy achieved by fibrinolytics and Percutaneous Coronary Intervention (PCI); both of which re-open occluded proximal arteries to restore blood flow to the affected areas. Despite revascularization therapy, 30-50% of patients exhibit a form of reperfusion injury termed “no/low-reflow” in which the blood …

Low Dose Aspirin Use For Primary Cardiovascular Prevention Among Lebanese Population, Walid Maassarani, A. El Mallah, Thuraya Domyati

BAU Journal - Health and Wellbeing

In spite of the controversies regarding low-dose aspirin safety and efficacy, aspirin is widely used by individuals for the primary prevention of myocardial infarction and ischemic stroke. This study assess the appropriateness of low dose aspirin use in a sample of Lebanese population. A cross sectional study was conducted using a community based questionnaire to assess each patient’s risk factors for Myocardial Infarction and ischemic stroke and possible contraindications for aspirin use. WHO risk score was used to calculate the cardiovascular risk of patients and determine the appropriateness of aspirin use for the primary prevention of cardiovascular diseases accordingly. Data …

The Role Of O-Glcnacase During Heart Failure., Sujith Dassanayaka

Electronic Theses and Dissertations

Global augmentation of protein O-GlcNAcylation occurs in response to a myriad of stressors and confers a survival advantage at the cellular level. This protective phenomenon has been demonstrated to mediate cardioprotection through various in vitro and in vivo studies during ischemia-reperfusion, myocardial infarction, and oxidative stress; however, relatively little is known of the regulation of protein O-GlcNAcylation. Protein O-GlcNAcylation is regulated by two antagonistic enzymes, namely, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Ablation of cardiomyocyte OGT, the enzyme that catalyzes the addition of O-GlcNAc to proteins, exacerbates cardiac dysfunction during infarct-induced heart failure (HF). However, little is known of the …

Epicardial Cell Engraftment And Signaling Promote Cardiac Repair After Myocardial Infarction, Krithika Rao

Graduate College Dissertations and Theses

The epicardium is a single layer of epithelial (mesothelial) cells that covers the entire heart surface, but whose function in adult mammals is poorly understood. Defining the role of epicardial cells during homeostasis, growth and injury has potential to provide new treatment strategies for human diseases that result in heart failure, due to extensive loss of viable cardiac tissue. We hypothesized that epicardial cells contribute to repair as transplantable progenitor cells for cellular regeneration and as a source of secreted growth factors for cell protection after myocardial infarction.

Adult epicardial cells were prospectively isolated as uncommitted epithelial cells using epithelial-specific …

Temporal Trends In Cardiogenic Shock Complicating Acute Myocardial Infarction, Robert J. Goldberg, Navid A. Samad, Jorge L. Yarzebski, Jerry H. Gurwitz, Carol Bigelow, Joel M. Gore

Jorge L. Yarzebski

BACKGROUND: Limited information is available on trends in the incidence of and mortality due to cardiogenic shock complicating acute myocardial infarction. We studied the incidence of cardiogenic shock complicating acute myocardial infarction and in-hospital death rates among patients with this condition in a single community from 1975 through 1997. METHODS: We conducted an observational study of 9076 residents of metropolitan Worcester, Massachusetts, who were hospitalized with confirmed acute myocardial infarction in all local hospitals during 11 one-year periods between 1975 and 1997. Our study included periods before and after the advent of reperfusion therapy. RESULTS: The incidence of cardiogenic shock …

Electrocardiographic-Vectorcardiographic Alterations And Laboratory Findings In Experimentally Myocardial Infarcted Dogs, Remzi̇ Gönül, Hüseyi̇n Tan

Turkish Journal of Veterinary & Animal Sciences

In this study, significant degrees of changes (p

Determination Of Kinetic, Structural And Functional Changes In The Hearts Of Dogs With Experimentally Introduced Myocardial Infarction Using M-Mode And 2-D Echocardiography, Utku Bakirel, Tarik Bi̇lal

Turkish Journal of Veterinary & Animal Sciences

In this study, the kinetic, structural and functional changes of the ventriculus in dogs with myocardial infarction introduced experimentally were examined using M-Mode and two dimensional (2-D) echocardiography. 21 healthy, mixed-breed dogs of both genders (16 females and 5 males) and of various ages were used in this study. Different coronary arteries were ligated in each dog with silk sutures and the dogs were grouped accordingly: left distalis descending coronary artery (Group I, n=7), right distalis descending coronary artery (Group II, n=7) and both left and right distalis decending coronary artery (Group III, n=7). All the dogs were examined using …