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Activation Of Orexin 1 Receptors In The Paraventricular Nucleus Contributes To The Development Of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation Of Vasopressin, Jeremy Bigalke, Huanjia Gao, Qing Hui Chen, Zhiying Shan
Activation Of Orexin 1 Receptors In The Paraventricular Nucleus Contributes To The Development Of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation Of Vasopressin, Jeremy Bigalke, Huanjia Gao, Qing Hui Chen, Zhiying Shan
Michigan Tech Publications
Salt-sensitivity is a major factor in the development of hypertension. The brain orexin system has been observed to play a role in numerous hypertensive animal models. However, orexin’s role in the pathology of salt-sensitive hypertension (SSH) remains to be adequately explored. We assessed the impact of orexin hyperactivity in the pathogenesis of the deoxycorticosterone acetate (DOCA) – salt rat model, specifically through modulation of Arginine Vasopressin (AVP). Adult male rats were separated into three groups: vehicle control, DOCA-salt, and DOCA-salt+OX1R-shRNA. DOCA-salt rats received subcutaneous implantation of a 21-day release, 75 mg DOCA pellet in addition to saline drinking water (1% …