Life Sciences Commons^™

Induction Of Neuroinflammation And Brain Oxidative Stress By Brain-Derived Extracellular Vesicles From Hypertensive Rats, Xinqian Chen, Xin Yan, Leah Gingerich, Qing Hui Chen, Lanrong Bi, Zhiying Shan

Michigan Tech Publications, Part 2

Neuroinflammation and brain oxidative stress are recognized as significant contributors to hypertension including salt sensitive hypertension. Extracellular vesicles (EVs) play an essential role in intercellular communication in various situations, including physiological and pathological ones. Based on this evidence, we hypothesized that EVs derived from the brains of hypertensive rats with salt sensitivity could trigger neuroinflammation and oxidative stress during hypertension development. To test this hypothesis, we compared the impact of EVs isolated from the brains of hypertensive Dahl Salt-Sensitive rats (DSS) and normotensive Sprague Dawley (SD) rats on inflammatory factors and mitochondrial reactive oxygen species (mtROS) production in primary neuronal …

Sleep And Risk For Metabolic Syndrome, Hypertension, Diabetes And Obesity Among Community-Dwelling Older Adults, Philip Zendels, Trudy L. Moore-Harrison, Jane F. Gaultney

International Journal of Exercise Science

International Journal of Exercise Science 15(3): 88-102, 2022. Older adults often face a variety of health problems that are found less frequently in younger populations. Metabolic syndrome and other related diseases are common due to a variety of age and lifestyle factors. Sleep, often operationalized only as duration, quality, or apnea diagnosis, is associated with worse health outcomes across the lifespan. However, sleep is multi-faceted and may require a collection of measures in order to reflect this. This study examined a suite of self-reported sleep habits (risk for sleep apnea, night time duration, nap duration, quality, timing, and consistency of …

Sympathoinhibition And Vasodilation Contribute To The Acute Hypotensive Response Of The Superoxide Dismutase Mimic, Mntnbuoe-2-Pyp5+, In Hypertensive Animals, Sarah L. Schlichte, Elizabeth J. Pekas, Taylor J. Bruett, Elizabeth A. Kosmacek, Bryan T. Hackfort, Jordan M. Rasmussen, Kaushik P. Patel, Song-Young Park, Rebecca E. Oberley-Deegan, Matthew C. Zimmerman

Health and Kinesiology Faculty Publications

The pathogenesis of hypertension has been linked to excessive levels of reactive oxygen species (ROS), particularly superoxide (O2•−), in multiple tissues and organ systems. Overexpression of superoxide dismutase (SOD) to scavenge O2•− has been shown to decrease blood pressure in hypertensive animals. We have previously shown that MnTnBuOE-2-PyP5+ (BuOE), a manganese porphyrin SOD mimic currently in clinical trials as a normal tissue protector for cancer patients undergoing radiation therapy, can scavenge O2•− and acutely decrease normotensive blood pressures. Herein, we hypothesized that BuOE decreases hypertensive blood pressures. Using angiotensin II (AngII)-hypertensive mice, we demonstrate that BuOE administered both intraperitoneally and …

Activation Of Orexin 1 Receptors In The Paraventricular Nucleus Contributes To The Development Of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation Of Vasopressin, Jeremy Bigalke, Huanjia Gao, Qing Hui Chen, Zhiying Shan

Michigan Tech Publications

Salt-sensitivity is a major factor in the development of hypertension. The brain orexin system has been observed to play a role in numerous hypertensive animal models. However, orexin’s role in the pathology of salt-sensitive hypertension (SSH) remains to be adequately explored. We assessed the impact of orexin hyperactivity in the pathogenesis of the deoxycorticosterone acetate (DOCA) – salt rat model, specifically through modulation of Arginine Vasopressin (AVP). Adult male rats were separated into three groups: vehicle control, DOCA-salt, and DOCA-salt+OX1R-shRNA. DOCA-salt rats received subcutaneous implantation of a 21-day release, 75 mg DOCA pellet in addition to saline drinking water (1% …

The Effects Of Mat Pilates Training On Vascular Function And Body Fatness In Obese Young Women With Elevated Blood Pressure, Alexei Wong, Arturo Figueroa, Stephen M. Fischer, Reza Bagheri, Song-Young Park

Health and Kinesiology Faculty Publications

BACKGROUND

Effective nonpharmacological interventions targeting the enhancement of vascular function and decline of body fatness (BF) in obese individuals are indispensable for the prevention of hypertension and cardiovascular events in young adults. Mat Pilates training (MPT) has gained significant popularity worldwide, yet its effects on vascular function and body composition are understudied. We examined the effects of MPT on vascular function and BF in young obese women with elevated blood pressure (BP). METHODS

Twenty-eight young obese women with elevated BP were randomized to an MPT (n = 14) or a nonexercising control (CON, n = 14) group for 12 …

Piloting A Smartphone-Based Sedentary Behavior Reduction Intervention For Adults With Overweight Or Obesity: Take A Stand 4 Health, Chelsea Larsen

Theses and Dissertations

INTRODUCTION: Previous studies have shown a relationship between sedentary behavior as an independent and novel risk factor for high blood pressure. However, most of the evidence comes from cross-sectional and experimental studies, with only a few studies examining whether blood pressure is improved in individuals participating in a behavioral intervention. None of these studies utilized mHealth approaches, which hold potential for behavioral interventions, and none have focused on individuals with hypertension as a part of their target population. Therefore, the purpose of the dissertation was to 1) Examine the efficacy of a smartphone-mediated multi-component sedentary behavior reduction intervention for individuals …

Examining The Effect Of Exercise Intensity On Post-Exercise Hypotension In Middle-Aged Adults, Seth F. Mccarthy

Theses and Dissertations (Comprehensive)

Acute bouts of exercise have a transient lowering effect on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in the hours after termed post-exercise hypotension (PEH). While moderate-intensity continuous training (MICT) is effective in reducing BP acutely, little is known regarding the effects of higher intensity exercise. This study examined the effects of different exercise intensities on PEH. Six participants (females: 4; age: 48±9 y, Mean arterial pressure: 84±8 mmHg) had their BP measured before and both immediately post- (<2 h) and for 24 h following 4 experimental sessions: 1) 30 min MICT (65% V̇O_2max); 2) 20 min high-intensity interval training (HIIT; 10 x 1 min @ 90% HR_max with 1 …

Taekwondo Training Reduces Blood Catecholamine Levels And Arterial Stiffness In Postmenopausal Women With Stage-2 Hypertension: Randomized Clinical Trial, Sang-Ho Lee, Steven D. Scott, Elizabeth J. Pekas, Seungyong Lee, Seok Hoon Lee, Song-Young Park

Health and Kinesiology Faculty Publications

Objective: Menopause is associated with a progressive impairment of vascular function and muscular strength in women. Accordingly, the purpose of this study was to determine if Taekwondo training could improve blood catecholamine levels, arterial stiffness, blood pressure (BP) and skeletal muscle strength in postmenopausal women with stage-2 hypertension.

Methods: 20 postmenopausal women (70 ± 4 years old) with stage-2 hypertension were randomly assigned to a 1) Taekwondo training (TT; n = 10) or 2) Control (CON; n = 10) group. Taekwondo training was performed for 60 minutes/day, 3 days/week for 12-weeks.

Results: There were significant (P …

Combined Exercise Training Reduces Blood Pressure, Arterial Stiffness, And Insulin Resistance In Obese Prehypertensive Adolescent Girls, Won-Mok Son, Ki-Dong Sung, Leena P. Bharath, Kong-Jib Choi, Song-Young Park

Health and Kinesiology Faculty Publications

Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in later adulthood. Obese adolescent girls with high blood pressure (BP) are reported to have increased arterial stiffness, which is associated with the development of hypertension and atherosclerosis. The present study sought to examine the impact of combined resistance and aerobic exercise (CRAE) training on BP, brachial-ankle pulse wave velocity (baPWV), insulin resistance (IR), and body composition in obese prehypertensive girls. Forty girls (age, 15 ± 1 years; systolic BP, 132 ± 2 mmHg, diastolic BP, 80 ± 5 mmHg) were randomly assigned to either a combined exercise (EX, …

Effects Of An 18- Week Strength, Conditioning, And Circuit Training Program On Weight Loss In A Middle Aged Adult Male, Aryeh D. Spingarn

Publications and Research

Aryeh Spingarn Queens College, City University of New York Department of Family, Nutrition, and Exercise Sciences, Effects of an 18-week strength, conditioning, and circuit training program on weight loss in a middle-aged male. Purpose: The purpose of this study was to examine the effects of a strength, conditioning, and circuit training program on weight loss in a middle age adult. Methods: The subject participated in an 18-week strength and conditioning program 2 days per week for one hour per session, totaling 2 hours of training time per week. The first 12 weeks of the program included only strength training for …

The Effect Of Cardiowaves Interval Training On Resting Blood Pressure, Resting Heart Rate, And Mind-Body Wellness, Camilla M. Nielson, Barbara D. Lockhart, Ronald L. Hager, James D. George, Dennis L. Eggett, Patrick R. Steffen, Ulrike H. Mitchell, Bruce W. Bailey

International Journal of Exercise Science

International Journal of Exercise Science 9(1): 89-100, 2016. An experimental study to examine the effects of CardioWaves interval training (CWIT) and continuous training (CT) on resting blood pressure, resting heart rate, and mind-body wellness. Fifty-two normotensive (blood pressure <120/80 mmHg), pre-hypertensive (120–139/80–89 mmHg), and hypertensive (>140/90 mmHg) participants were randomly assigned and equally divided between the CWIT and CT groups. Both groups participated in the assigned exercise protocol 30 minutes per day, four days per week for eight weeks. Resting blood pressure, resting heart rate, and mind-body wellness were measured pre- and post-intervention. A total of 47 participants (15 females and 32 males) were included in the …

Utility Of Anthropometric Measures In A Multiethnic Population: Their Association With Prevalent Diabetes, Hypertension And Other Chronic Disease Comorbidities, Heather P. Tarleton, Lisa V. Smith, Zuo-Feng Zhang, Tony Kuo

Health and Human Sciences Faculty Works

Body mass index (BMI) and waist circumference (WC) are two common anthropometric measures of obesity in clinical and public health practice. Consensus, however, remains elusive regarding their utility for predicting cardiovascular disease risk in multiethnic populations. We address this gap in the literature by analyzing cross-sectional data from the first round of the Los Angeles County Health and Nutrition Examination Survey, 2011. We characterized the relationships between BMI, WC, waist-to-hip ratios, waist-to-height ratios, and chronic disease extent, as confirmed by the presence of hypertension, diabetes, and/or two or more other chronic conditions as defined by a composite indicator ‘comorbidity’. To …

Aquatic Treadmill Training Reduces Blood Pressure Reactivity To Acute Graded Exercise In Previously Sedentary Adults, Brad S. Lambert, Nicholas P. Greene, Dustin P. Joubert, Steven E. Riechman, James D. Fluckey, Stephen F. Crouse, Alex T. Carradine

International Journal of Exercise Science: Conference Proceedings

Endurance exercise may reduce blood pressure and improve vasodilatory capacity thereby blunting the hypertensive response to stress. To test the efficacy of a novel model of low-impact endurance training, the aquatic-based treadmill (ATM), to improve blood pressure parameters, we recruited 60 sedentary adults and randomized to 12-weeks of either ATM (n = 36 [19 men, 17 women] , 41±2 yr, 173.58 ±1.58cm, 93.19 ±3.15kg) or land-based treadmill (LTM, n = 24 [11 men, 13 women], 42 ±2yr, 170.39 ±1.94cm, 88.14 ±3.6kg) training; 3sessions·wk-1, progressing to 500 kcal·session-1, 85% VO2max. The maximal Bruce treadmill test protocol was performed before and after …

Osteoblast Activity Is Diminished In Young Spontaneously Hypertensive Rats, Tyler J. Benson, Brandon Cherry, Steve Mifflin, Rhonda Prisby

International Journal of Exercise Science: Conference Proceedings

Spontaneously Hypertensive Rats (SHR) are used as a genetic model of essential hypertension. Reductions in cortical and cancellous bone mass and increased bone turnover have been observed in aged SHR vs. Wistar-Kyoto (WKY) rats, normotensive genetics controls. In addition, antihypertensive aids have been effective in improving bone parameters in hypertensive rats. Thus, the relation between hypertension and bone remodeling warrants further attention. The purpose of this study was to determine how acute (i.e., 9 weeks) hypertension effects bone remodeling parameters (i.e., osteoclast and osteoblast activity). Methods: Right femora from 14-week-old SHR (n=5) and WKY (n=4) rats were dissected, fixed in …

Cerebral Hemodynamics After Short- And Long-Term Reduction In Blood Pressure In Mild And Moderate Hypertension, Rong Zhanf, Sarah Witkowski, Qi Fu, Jurgen A.H.R. Claassen, Benjamin D. Levine

Exercise and Sport Studies: Faculty Publications

This study tested the hypothesis that acute reduction in blood pressure (BP) at the initial stage of antihypertensive therapy compromises brain perfusion and dynamic cerebral autoregulation in patients with hypertension. Cerebral blood flow velocity and BP were measured in patients with mild and moderate hypertension and in healthy volunteers at baseline upon reduction of BP within 1 to 2 weeks of administration of losartan/hydrochlorothiazide and after 3 to 4 months of treatment. The transfer function between beat-to-beat changes in BP and cerebral blood flow velocity was estimated to assess dynamic autoregulation. After 1 to 2 weeks of treatment, BP was …