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Full-Text Articles in Life Sciences
Cerebral Hemodynamics After Short- And Long-Term Reduction In Blood Pressure In Mild And Moderate Hypertension, Rong Zhanf, Sarah Witkowski, Qi Fu, Jurgen A.H.R. Claassen, Benjamin D. Levine
Cerebral Hemodynamics After Short- And Long-Term Reduction In Blood Pressure In Mild And Moderate Hypertension, Rong Zhanf, Sarah Witkowski, Qi Fu, Jurgen A.H.R. Claassen, Benjamin D. Levine
Exercise and Sport Studies: Faculty Publications
This study tested the hypothesis that acute reduction in blood pressure (BP) at the initial stage of antihypertensive therapy compromises brain perfusion and dynamic cerebral autoregulation in patients with hypertension. Cerebral blood flow velocity and BP were measured in patients with mild and moderate hypertension and in healthy volunteers at baseline upon reduction of BP within 1 to 2 weeks of administration of losartan/hydrochlorothiazide and after 3 to 4 months of treatment. The transfer function between beat-to-beat changes in BP and cerebral blood flow velocity was estimated to assess dynamic autoregulation. After 1 to 2 weeks of treatment, BP was …