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The Developmental And Behavioral Effects Of Δ9-Tetrahydrocannabinol On A Spastic Mutant, Victoria Mendiola
The Developmental And Behavioral Effects Of Δ9-Tetrahydrocannabinol On A Spastic Mutant, Victoria Mendiola
Master of Science in Integrative Biology Theses
Hyperekplexia is a neurological disorder affecting infants and can be characterized by excessive startle reactions in response to unexpected stimuli. This disease can be modeled in zebrafish in the bandoneon (beo) mutant, where the glrbbmutation results in glycine receptor (GLYR) loss of function glycine receptors and ultimately, improper inhibitory signaling. Though hyperekplexia is a glycinergic-based signaling disorder, disease symptoms are often alleviated with GABA-agonistic benzodiazepines. Exogenous cannabinoids also modulate GABAergic signaling, and THC, one of the natural compounds that prompted the discovery of the endocannabinoid system mimics the effects of endogenous cannabinoids at endocannabinoid and non-cannabinoid sites in the …