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Elucidating Binding, Fusion And Entry Of Human Metapneumovirus, Edita M. Klimyte
Elucidating Binding, Fusion And Entry Of Human Metapneumovirus, Edita M. Klimyte
Theses and Dissertations--Molecular and Cellular Biochemistry
Human metapneumovirus (HMPV) is a respiratory pathogen in the Paramyxoviridae family that infects nearly 100% of the world population. This enveloped RNA virus causes severe viral respiratory disease in infants, the elderly, and immunocompromised patients worldwide. Despite its prevalence and importance to human health, no therapies are available against this pathogen. Entry of paramyxoviruses into host cells generally requires the coordinated activity of the attachment glycoprotein, G, which interacts with a cell receptor, and the fusion glycoprotein, F, which promotes subsequent fusion of viral and cellular membranes. However, HMPV F is the primary viral protein mediating both binding and fusion …