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Full-Text Articles in Life Sciences
Staufen Negatively Modulates Microrna Activity In Caenorhabditis Elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, Victor Ambros
Staufen Negatively Modulates Microrna Activity In Caenorhabditis Elegans, Zhiji Ren, Isana Veksler-Lublinsky, David Morrissey, Victor Ambros
Victor R. Ambros
The double-stranded RNA-binding protein Staufen has been implicated in various post-transcriptional gene regulatory processes. Here we demonstrate that the Caenorhabditis elegans homolog of Staufen, STAU-1, functionally interacts with microRNAs. Loss-of-function mutations of stau-1 significantly suppress phenotypes of let-7 family microRNA mutants, a hypomorphic allele of dicer and a lsy-6 microRNA partial loss-of-function mutant. Furthermore, STAU-1 modulates the activity of lin-14, a target of lin-4 and let-7 family microRNAs, and this modulation is abolished when the 3' untranslated region of lin-14 is removed. Deep sequencing of small RNA cDNA libraries reveals no dramatic change in the levels of microRNAs, or other …
Exploring Identity Through Genetic And Genealogical Research, James Doan, Emily Schmitt Lavin
Exploring Identity Through Genetic And Genealogical Research, James Doan, Emily Schmitt Lavin
Emily F Schmitt Lavin
In this presentation, Schmitt and Doan examined data from student projects completed in their HONR 1000N Genetics and Genealogy course, taught during winter 2010. Students traced their deep ancestry through mitochondrial and Y-chromosome DNA analysis, as well as more recent ancestry, using genealogical databases and family histories. Frequently, students were challenged or pleasantly surprised by the information they gleaned. Genetic and genealogical research can provide clues to one’s identity and ethnic background, as well as potential medical conditions.
Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration., Michael M. Moran, Madhuri Kango-Singh, Amit Singh
Homeotic Gene Teashirt (Tsh) Has A Neuroprotective Function In Amyloid-Beta 42 Mediated Neurodegeneration., Michael M. Moran, Madhuri Kango-Singh, Amit Singh
Amit Singh
Background: Alzheimer's disease (AD) is a debilitating age related progressive neurodegenerative disorder characterized by the loss of cognition, and eventual death of the affected individual. One of the major causes of AD is the accumulation of Amyloid-beta 42 (Aβ42) polypeptides formed by the improper cleavage of amyloid precursor protein (APP) in the brain. These plaques disrupt normal cellular processes through oxidative stress and aberrant signaling resulting in the loss of synaptic activity and death of the neurons. However, the detailed genetic mechanism(s) responsible for this neurodegeneration still remain elusive. Methodology/ Principle Findings: We have generated a transgenic Drosophila eye model …
Pre-Settlement History May Obscure The Effect Of Forest Fragmentation On Genetic Variation In Eastern Red-Backed Salamanders, Mark Jordan, Douglas Morris, Scott Gibson
Pre-Settlement History May Obscure The Effect Of Forest Fragmentation On Genetic Variation In Eastern Red-Backed Salamanders, Mark Jordan, Douglas Morris, Scott Gibson
Mark A. Jordan
No abstract provided.
Biomedical Research And The Law:--Embryonic Stem Cells, Clones And Genes: Science, Law, Politics, And Values, Michael J. Malinowski
Biomedical Research And The Law:--Embryonic Stem Cells, Clones And Genes: Science, Law, Politics, And Values, Michael J. Malinowski
Michael J. Malinowski
This article directly addresses the stem cell controversy, but also the broader history and norms regarding the roles of federal and state government in U.S. science research funding.
On The Status Of The Serranid Fish Genus Epinephelus: Evidence For Paraphyly Based Upon 16s Rdna Sequence, Matthew T. Craig, Daniel Pondella Ii, Jens P.C Franckb, John C. Hafner
On The Status Of The Serranid Fish Genus Epinephelus: Evidence For Paraphyly Based Upon 16s Rdna Sequence, Matthew T. Craig, Daniel Pondella Ii, Jens P.C Franckb, John C. Hafner
Daniel Pondella
Historically, attempts to elucidate evolutionary relationships among members of the genus Epinephelus (Teleostei: Serranidae), commonly known as groupers, have been hindered by the overwhelming number of species (98, sensu stricto), a pan global distribution, and the lack of morphological specializations traditionally used in ichthyological classification. To date, no comprehensive phylogenetic study, morphological or molecular, to evaluate the monophyly of this genus has been presented. In this study, previous hypotheses regarding the relationships among the American grouper species and the allied genera were evaluated by examination of mitochondrial DNA sequences of the 16S ribosomal DNA region. A 590-bp region of the …