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The Effects Of Anabolic-Androgenic Steroids On Gene Expression In Skeletal Muscle: A Systematic Review, Luke M. Pelton, Stephen A. Maris, Joshua Loseke
The Effects Of Anabolic-Androgenic Steroids On Gene Expression In Skeletal Muscle: A Systematic Review, Luke M. Pelton, Stephen A. Maris, Joshua Loseke
International Journal of Exercise Science
International Journal of Exercise Science 16(3): 53-82, 2023. Anabolic-androgenic steroids (AAS) act via androgen receptor (AR) interaction to induce muscle protein synthesis. This process is achieved via altered gene expression via the Notch, Wnt, and Numb pathways and their interactions at the AR, manifesting in key skeletal muscle (SM) phenotypes such as morphology, ion conductance, and functionality. This review aims to report on the effects of AAS administration on gene expression in SM. Peer-reviewed empirical studies evaluating AAS administration on SM phenotypes and gene expression were considered for inclusion. The following databases were searched using a data range of Jan …