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Articles 1 - 15 of 15
Full-Text Articles in Life Sciences
An Epigenetically Driven Relationship Between Parental Ptsd And Inflammatory Disease In Offspring: A Proposal, Emma Griffith, Kevin P. Kaut
An Epigenetically Driven Relationship Between Parental Ptsd And Inflammatory Disease In Offspring: A Proposal, Emma Griffith, Kevin P. Kaut
Journal of Neuropsychology and Behavioral Processes
Could a combat veteran's horrific experiences in early-2000s Afghanistan have a direct, biological impact on his or her now-adult daughter's risk of a heart attack later in her life? This concept would have been unapologetically mocked a mere twenty years ago, and it has only been in the past decade that the new field of epigenetics has revealed a distinct possibility for this event to actually take place—for parents' experiences to profoundly influence the biology of their children. The major objective of this research project is to argue for the legitimacy of this theoretical phenomenon by discussing the latest data …
Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso
Sex And Gender In Ageing And Longevity: Highlights From An International Course, Giuseppina Candore, Giulia Accardi, Anna Aiello, Giovannella Baggio, Tiziana Bellini, Vittorio Calabrese, Anna Paola Carreca, Ignazio Carreca, Anna Masucci, Monica Cattaneo, Serena Dato, Danilo Di Bona, Luca Fabris, Caterina Gambino, Gabriele Di Lorenzo, Claudio Franceschi, Mattia Emanuela Ligotti, Maria Cristina Manfrinato, Annibale Alessandro Puca, Martina Tamburello, Roberta Vassallo, Calogero Caruso
Translational Medicine @ UniSa
Gender medicine is a multidisciplinary science and represents an important perspective for pathophysiological and clinical studies in the third millennium. Here, it is provided an overview of the topics discussed in a recent course on the Role of Sex and Gender in Ageing and Longevity. The paper highlights three themes discussed in the course, i.e., the interaction of gender/sex with, i) the pathophysiology of age-related diseases; ii), the role of genetics and epigenetics in ageing and longevity and, iii) the immune responses of older people to pathogens, vaccines, autoantigens, and allergens. Although largely unexplored, sex and gender are modulators …
Inducible Resistance To Pyrethroid Insecticide Is Lacking In Adult Aedes Aegypti Mosquitoes, Maria E. Parente, Philip K. Stoddard
Inducible Resistance To Pyrethroid Insecticide Is Lacking In Adult Aedes Aegypti Mosquitoes, Maria E. Parente, Philip K. Stoddard
FIU Undergraduate Research Journal
Mosquitoes have evolved increased resistance to pyrethroid insecticides including permethrin, and studying their metabolic mechanisms of resistance is the window to human counteraction. If early exposure to insecticides can upregulate certain detoxification genes, this creates lower rates of mortality in a single mosquito’s lifetime. Yellow fever mosquitoes (Aedes aegypti) were exposed to a sublethal dosage of permethrin and mortality rates at a later LC50 dose exposure were recorded. Mortality rates of induced mosquitoes were not lower than the mortality rates of unexposed (control) mosquito groups. If early exposure did not increase mortality, either evidence for inducible same-generational …
The Effects Of Anabolic-Androgenic Steroids On Gene Expression In Skeletal Muscle: A Systematic Review, Luke M. Pelton, Stephen A. Maris, Joshua Loseke
The Effects Of Anabolic-Androgenic Steroids On Gene Expression In Skeletal Muscle: A Systematic Review, Luke M. Pelton, Stephen A. Maris, Joshua Loseke
International Journal of Exercise Science
International Journal of Exercise Science 16(3): 53-82, 2023. Anabolic-androgenic steroids (AAS) act via androgen receptor (AR) interaction to induce muscle protein synthesis. This process is achieved via altered gene expression via the Notch, Wnt, and Numb pathways and their interactions at the AR, manifesting in key skeletal muscle (SM) phenotypes such as morphology, ion conductance, and functionality. This review aims to report on the effects of AAS administration on gene expression in SM. Peer-reviewed empirical studies evaluating AAS administration on SM phenotypes and gene expression were considered for inclusion. The following databases were searched using a data range of Jan …
Arid4b Physically Interacts With Tfap2c In Mouse Embryonic Stem Cells, Ezgi̇ Gül Keski̇n, Jialiang Huang, Ni̇hal Terzi̇ Çi̇zmeci̇oğlu
Arid4b Physically Interacts With Tfap2c In Mouse Embryonic Stem Cells, Ezgi̇ Gül Keski̇n, Jialiang Huang, Ni̇hal Terzi̇ Çi̇zmeci̇oğlu
Turkish Journal of Biology
Precise regulation of gene expression is required for embryonic stem cell (ESC) differentiation. Transcription factor (TF) networks coordinate the balance of pluripotency and differentiation in response to extracellular and intracellular signals. Chromatin factors work alongside TFs to achieve timely regulation of gene expression for differentiation process. Our previous studies showed that a member of the Sin3a corepressor complex, Arid4b, is critical for proper mouse ESC differentiation into mesoderm and endoderm. We found elevated histone 3 lysine 27 acetylation (H3K27Ac) in a subset of genomic loci in meso/endoderm directed arid4b? cells, coincident with their derepression. We reasoned that Sin3a complex may …
Msap Analysis Reveals Diverse Epigenetic Statuses In Opium Poppy Varieties With Different Benzyisoquinoline Alkaloid Content, Betül Bulut, Zehra Aydinli, Mi̇ne Türktaş
Msap Analysis Reveals Diverse Epigenetic Statuses In Opium Poppy Varieties With Different Benzyisoquinoline Alkaloid Content, Betül Bulut, Zehra Aydinli, Mi̇ne Türktaş
Turkish Journal of Biology
DNA methylation is one of the major epigenetic modifications influencing the regulation of gene expression. The opium poppy is an important medicinal plant. Its latex contains opium, which is a rich source of pharmaceutical benzyisoquinoline alkaloids (BIA). Here, the methylation-sensitive amplification polymorphism (MSAP) profiling technique using 21 MSAP molecular markers was applied in order to compare levels of DNA methylation between 6 opium poppy varieties. MSAP profiling reflected the different methylation statuses among opium poppy varieties having divergent BIA content. Moreover, different organ-specific epigenetic profiles were observed between the samples. Differential epigenetic profiles of capsules and shoots from the leaves …
G-Quadruplex Enrichment Analysis Reveals Their Role As Intronic Regulatory Elements In Plants, Osman Doluca
G-Quadruplex Enrichment Analysis Reveals Their Role As Intronic Regulatory Elements In Plants, Osman Doluca
Turkish Journal of Botany
G-Quadruplexes, a class of noncanonical but highly stable nucleic acid structures, have the potential to be part of the regulatory mechanism of cells. They can form in the genome where the double-stranded helix is unwound to facilitate formation of a G-quadruplex. The biological significance of these structures is yet to be understood entirely. This work presents a novel approach and investigates common characteristics in the distribution of G-quadruplexes relative to genes in plants through analysis of genomes and gene expressions. The results indicate that G-quadruplex distribution has gone through significant changes with the evolution of higher plants and, for the …
Are Health Problems In Adulthood Linked To Our Experiences In The Womb? An Epigenetic Approach, Simone Tendler
Are Health Problems In Adulthood Linked To Our Experiences In The Womb? An Epigenetic Approach, Simone Tendler
The Science Journal of the Lander College of Arts and Sciences
The origins of adult disease have been a prime topic for research, as deciphering causes can lead to strategies for preventions and cures. There has been recent intrigue focused on the environment in the womb. Records from England and Wales in 1911 show that those who suffered from cardiovascular disease were geographically correlated with regions high in infant mortality in the past, seventy years before the study. When looking into the cause of the neonatal death rates, low birth weight, poor maternal health, and high maternal death rates during childbirth were clearly associated. Barker inferred that there is much happening …
Continuous Environmental Tracking: An Engineering Framework To Understand Adaptation And Diversification, Randy J. Guliuzza, Phil Gaskill
Continuous Environmental Tracking: An Engineering Framework To Understand Adaptation And Diversification, Randy J. Guliuzza, Phil Gaskill
Proceedings of the International Conference on Creationism
We offer a new framework for understanding biological adaptability based on interpreting the findings of 342 journal articles and 67 online reports related to adaptation, bioengineering, and design in view of the assumption that biological functions are most accurately explained by engineering principles. We hypothesize that organisms actively and continuously track environmental variables and respond by self-adjusting to changing environments—utilizing the engineering principles constraining how human-designed objects self-adjust to changes—which results in adaptation. We termed this hypothesis Continuous Environmental Tracking (CET). CET is an engineering-based, organism-focused characterization of adaptation. CET expects to find that organisms adapt via systems with elements …
The Search For A Hero Gene: Fact Or Fiction?, Olivia Efthimiou
The Search For A Hero Gene: Fact Or Fiction?, Olivia Efthimiou
Heroism Science
The radical entry of heroism research into scientific inquiry presents interesting challenges and possibilities for the study of heroism and the human condition more broadly. This ‘final frontier’ of the enduring phenomenon of heroism stands to offer remarkable, unprecedented, and controversial advances in our understanding of heroic and human behaviour. Is a genetic basis for heroism a real possibility? If so, what would its impacts be? Advances in genomics and increased interest in the fields of epigenetics and neuroplasticity might hold the key to its discovery. This article considers some of the leading emerging research in global health genomics and …
The Effects Of Epigenetics On Stress Response, Kevin Suddarth
The Effects Of Epigenetics On Stress Response, Kevin Suddarth
Themis: Research Journal of Justice Studies and Forensic Science
Despite the vast amount of resources at the disposal of humanity today, the intricacies of human biology are often a mystery. The chemical and biological products of the human genome have been well studied and documented, but many of the chemical and neurological pathways are missing quite a few details. The human stress response is one of the most primal and valuable functions of this code that developed as a self- preservation mechanism (Hans, 1975) to naturally increase the odds of procreation. However, this function is prone to overload, particularly in individuals with certain epigenetic traits instilled by early life …
Beyond Dna: Epigenetics And Proteomics In Forensic Science, Diane F. Eilerts
Beyond Dna: Epigenetics And Proteomics In Forensic Science, Diane F. Eilerts
Themis: Research Journal of Justice Studies and Forensic Science
The use of genetic evidence in criminal cases is well established and has improved the public opinion and credibility of forensic science. However, several shortcomings associated with current genetic profiling techniques exist. Scientific research aimed at increasing the overall knowledge and understanding of biological factors will lead to the development of methods capable of improving the discriminating power of DNA evidence, overcoming limitations associated with DNA evidence, or complementing current methods of DNA profiling. Increased research in the fields of epigenetics and proteomics are particularly promising and relevant to forensic science. Research suggests that epigenetic biomarkers can be used to …
The Sensitivity Of 5-Formylcytosine To Doxorubicin Regardless Of Dna Damage, Selcen Çeli̇k Uzuner, Chris O'Neill
The Sensitivity Of 5-Formylcytosine To Doxorubicin Regardless Of Dna Damage, Selcen Çeli̇k Uzuner, Chris O'Neill
Turkish Journal of Biology
We have previously shown that DNA damage induced by doxorubicin was associated with an increase in the level of DNA methylation, 5meC, in mouse embryonic fibroblasts using a developed immunostaining methodology. Doxorubicin (also known as adriamycin), which induces double-strand DNA breaks, has been widely used in cancer therapy. Cytosine modifications are dynamically regulated in the genome during lifespan, but abnormal changes in the 5meC pattern can be associated with diseases in particular cancer progressions and DNA damage. One of the side effects of cancer therapy is that chemotherapeutic agents can damage healthy cells as well as cancerous cells. In this …
Epigenetics: The Guardian Of Pluripotency And Differentiation, Marta Gladych, Aleksandra Nijak, Paula Lota, Urszula Oleksiewicz
Epigenetics: The Guardian Of Pluripotency And Differentiation, Marta Gladych, Aleksandra Nijak, Paula Lota, Urszula Oleksiewicz
Turkish Journal of Biology
Multicellular organisms comprise a variety of cell types that have the same genotype but distinct phenotypes. This diversity is possible because of the establishment of a specific epigenetic landscape that stabilizes gene expression profiles that are exclusive for a particular cell type. Accumulating data indicate that the maintenance, loss, and reacquisition of pluripotency are dynamically regulated by epigenetic alterations evoked by a subset of cellular factors. A better understanding of the epigenetic mechanisms involved in stem cell biology and differentiation will improve our ability to use these cells in the clinical context. Here we review current insights into the epigenetic …
Epigallocatechin 3-Gallate Applications On Ht-29 And Mcf-7 Cell Lines Andevaluation Of Tumor Suppressor Gene Methylation, Yunus Kasim Terzi̇, Özge Özer Kaya, Özlem Darcansoy İşeri̇, Zerri̇n Çeli̇k, Feri̇de İffet Şahi̇n
Epigallocatechin 3-Gallate Applications On Ht-29 And Mcf-7 Cell Lines Andevaluation Of Tumor Suppressor Gene Methylation, Yunus Kasim Terzi̇, Özge Özer Kaya, Özlem Darcansoy İşeri̇, Zerri̇n Çeli̇k, Feri̇de İffet Şahi̇n
Turkish Journal of Biology
No abstract provided.