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Full-Text Articles in Life Sciences
Potential Mechanisms Explaining The Antitumor Effect Of Total-Body Irradiation, Glen Michael Miller
Potential Mechanisms Explaining The Antitumor Effect Of Total-Body Irradiation, Glen Michael Miller
Loma Linda University Electronic Theses, Dissertations & Projects
While numerous reports have documented that radiation exposure increases the risk for malignancy and suppresses immune mechanisms, increasing evidence has suggested that low-dose total-body irradiation (TBI) may alter leukocyte composition and function leading to heightened immune responsiveness and long-term remission of certain cancers. Having observed that moderate-dose TBI produces an antitumor effect in the Lewis lung carcinoma (EEC) model, the major goal of this study was to determine whether changes in tumor growth could be correlated with radiation-induced alterations of immune system parameters. The governing hypothesis was that selective immune augmentation, i.e. upregulation of specific leukocyte subsets, is primarily responsible …
Photodynamic Therapy, Ashley Thomas
Photodynamic Therapy, Ashley Thomas
McCabe Thesis Collection
Photodynamic therapy is a new treatment that is being introduced into the veterinary community. Photodynamic therapy is the use of light activated chemotherapy to kill cancer cells (Dougherty, 1998). It has already been approved by the US Food and Drug Administration to be used as a form of cancer treatment in humans, but has not been carried over to the veterinary community. That is until now. Photodynamic therapy is now being tested in the veterinary community in hopes to find the same results that the human medical community has when dealing with certain types of cancer. They also hope to …
The Ecological Ramifications Of Disease And Density In The Caribbean Spiny Lobster, Panulirus Argus, Donald C. Behringer Jr.
The Ecological Ramifications Of Disease And Density In The Caribbean Spiny Lobster, Panulirus Argus, Donald C. Behringer Jr.
Biological Sciences Theses & Dissertations
In 1999, I discovered the first virus known to be pathogenic to any species of lobster. HLV-PA is a pathogenic herpes-like virus that infects juvenile Caribbean spiny lobster, Panulirus argus, in the waters off south Florida (USA), and it alters the behavior and ecology of this species in fundamental ways. Gross signs of HLV-PA infection are lethargy, morbidity, cessation of molting, and discolored, “milky” hemolymph that does not clot. HLV-PA infects the hemocytes of host lobsters, specifically the hyalinocytes and semi-granulocytes, but not the granulocytes. When hemolymph from infected donors was injected into healthy juvenile lobsters, 90% of the …
The Short-Term Effects Of Grade 1 And 2 Joint Mobilizations On Subject Pain Range Of Motion And Muscle Activity In The Pathological Lumbar Spine, Sean Hanrahan
Human Movement Sciences & Special Education Theses & Dissertations
The purpose of this study was to examine the short-term effects of Grades 1 and 2 posteroanterior joint mobilizations (JM) at the pathological lumbar spine on subject pain, range of motion (ROM), and muscle force. All subjects were determined to have sustained mechanical dysfunction of the lumbar spine of less than 48 hours as assessed through a standardized evaluation. Subjects were randomly assigned to a group; the control group received ice and stretching while the experimental group received JM in addition to ice and stretching. The JM's were performed at 3 consecutive lumbar segments surrounding the area of greatest discomfort. …
Regulation Of Proto-Oncogenes Expression In Developmental Epilepsy, Mahnoush Shafiei
Regulation Of Proto-Oncogenes Expression In Developmental Epilepsy, Mahnoush Shafiei
Seton Hall University Dissertations and Theses (ETDs)
Seizures cause selective neuronal cell loss in vulnerable regions such as the hippocampus, cortex, thalamus or substantia nigra (SN) in human or experimental animals. While the HF can propagate seizures, the SN pars reticulata (SNR) regulates the spread ol seizures in an age-dependent fashion, and the pars compacta (SNC) affects extrapyramidal motor control. In mature animals, both structures are wlnerable to seizure-induced damage. In prepubescent rats, seizure susceptibility is reduced and CA 1 region rs primarily affected. The proto-oncogenes, Bcl-2 and Bax, encode specific proteins that inhibit and promote programmed cell death, respectively. In order to determine whether proto-oncogenes are …