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Flow Of Dna Solutions In A Microfluidic Gradual Contraction, Shelly Gulati, Susan J. Muller, Dorian Liepmann
Flow Of Dna Solutions In A Microfluidic Gradual Contraction, Shelly Gulati, Susan J. Muller, Dorian Liepmann
Shelly Gulati
The flow of λ-DNA solutions in a gradual micro-contraction was investigated using direct measurement techniques. The effects on DNA transport in microscale flows are significant because the flow behavior is influenced by macromolecular conformations, both viscous and elastic forces dominate inertial forces at this length scale, and the fully extended length of the molecule approaches the characteristic channel length wc (L/wc ∼ 0.13). This study examines the flow of semi-dilute and entangled DNA solutions in a gradual planar micro-contraction for low Reynolds numbers (3.7 × 10−6 < Re < 3.1 × 10−1) and high Weissenberg numbers (0.4 < Wi < …