Life Sciences Commons^™

Trust In Social And Sensor Networks, Pramod Anantharam, Krishnaprasad Thirunarayan, Cory Andrew Henson, Amit P. Sheth

Kno.e.sis Publications

Trust can be defined as the perception of the trustor about the degree to which the trustee would satisfy an expectation about a transaction constituting risk. Trust plays a pivotal role when the risk in believing incorrect information is high. With Web 2.0 where user generated content and real time interactions dominate, the openness of data contribution may hinder the quality of information we can get.

Semantics-Empowered Text Exploration For Knowledge Discovery, Delroy H. Cameron, Pablo N. Mendes, Amit P. Sheth, Victor Chan

Kno.e.sis Publications

The interaction paradigm offered by most contemporary Web Information Systems is a search-and-sift paradigm in which users manually seek information using hyperlinked documents. This paradigm is derived from a document-centric model that gives users minimal support for scanning through high volumes of text. We present a novel information exploration paradigm based on a data-centric view of corpora, along with a prototype implementation that demonstrates the value in content-driven navigation. We leverage semantic metadata to link data in documents by exploiting named relationships between entities. We also present utilities for gathering user generated navigation trails, critical for knowledge discovery. We discuss …

What Goes Around Comes Around - Improving Linked Open Data Through On-Demand Model Creation, Christopher Thomas, Wenbo Wang, Pankaj Mehra, Delroy H. Cameron, Pablo N. Mendes, Amit P. Sheth

Kno.e.sis Publications

Web 2.0 has changed the way we share and keep up with information. We communicate through social media platforms and make the information we exchange to a large extent publicly available. Linked Open Data (LOD) follows the same paradigm of sharing information but also makes it machine accessible. LOD provides an abundance of structured information albeit in a less formally rigorous form than would be desirable for Semantic Web applications. Nevertheless, most of the LOD assertions are community reviewed and we can rely on their accuracy to a large extent. In this work we want to follow the Web 2.0 …

Dynamic Associative Relationships On The Linked Open Data Web, Pablo N. Mendes, Pavan Kapanipathi, Delroy H. Cameron, Amit P. Sheth

Kno.e.sis Publications

We provide a definition of context based on theme, time and location, and propose a mixed retrieval/extraction model for the dynamic suggestion of trending relationships to LOD resources.

Volume 03, Cheryl Peck, Charles Hoever, Longwood Theater Department, Brittany Anderson, J. Ervin Sheldon, Richard Hayden, Yuri Calustro, Candice Fleming, Rebecca Franklin, Ashley Yocum, Danielle M. Jagoda, Cristina M. Valdivieso, Jameka Jones, Amy Ellis, Ashley Maser, Erikk Shupp, Jamie Yurasits, Joshua Davis, Alexander Leonhart, Kenny Wolfe, Sally Meadows, J. Haley, Amy Jackson, Morgan Howard, Adrienne Heinbaugh, Melissa Dorton, Ciarra Stalker

Incite: The Journal of Undergraduate Scholarship

Introduction from Dean Dr. Charles Ross

Little Shop of Horrors by Longwood Theater Department

Who Has the Hottest Hotsauce in Farmville: A Quantitative Comparison of Sauces from Local Restaurants by Cheryl Peck and Charles Hoever

Precipitation Effects on the Growth of White Oaks and Virginia Pines on the Mt. Vernon Plantation by Brittany Anderson

Design and Synthesis of Novel Ion Binding Molecules for Self-Assembly and Sensing Applications by J. Ervin Sheldon

A Statistical Analysis of Algorithms for Playing SameGame by Richard Hayden

Intersecting Cylinders at Arbitrary Angles by Yuri Calustro

Putting a Foot in the Revolving Door: Strategies for Reducing …

A Framework For Automated Enrichment Of Functionally Significant Inverted Repeats In Whole Genomes, Cyriac Kandoth, Fikret ErçAl, Ronald L. Frank

Computer Science Faculty Research & Creative Works

Background: RNA transcripts from genomic sequences showing dyad symmetry typically adopt hairpin-like, cloverleaf, or similar structures that act as recognition sites for proteins. Such structures often are the precursors of non-coding RNA (ncRNA) sequences like microRNA (miRNA) and small-interfering RNA (siRNA) that have recently garnered more functional significance than in the past. Genomic DNA contains hundreds of thousands of such inverted repeats (IRs) with varying degrees of symmetry. But by collecting statistically significant information from a known set of ncRNA, we can sort these IRs into those that are likely to be functional.

Results: A novel method was developed to …

Linked Open Social Signals, Pablo N. Mendes, Alexandre Passant, Pavan Kapanipathi, Amit P. Sheth

Kno.e.sis Publications

In this paper we discuss the collection, semantic annotation and analysis of real-time social signals from micro-blogging data. We focus on users interested in analyzing social signals collectively for sensemaking. Our proposal enables flexibility in selecting subsets for analysis, alleviating information overload. We define an architecture that is based on state-of-the-art Semantic Web technologies and a distributed publish subscribe protocol for real time communication. In addition, we discuss our method and application in a scenario related to the health care reform in the United States.

A Multidimensional Strategy To Detect Polypharmacological Targets In The Absence Of Structural And Sequence Homology, Jacob D. Durrant, Rommie E. Amaro, Lei Xie, Michael D. Urbaniak, Michael A. J. Ferguson, Antti Haapalainen, Zhijun Chen, Anne Marie Di Guilmi, Frank Wunder, Philip E. Bourne, J. Andrew Mccammon

Publications and Research

Conventional drug design embraces the ‘‘one gene, one drug, one disease’’ philosophy. Polypharmacology, which focuses on multi-target drugs, has emerged as a new paradigm in drug discovery. The rational design of drugs that act via polypharmacological mechanisms can produce compounds that exhibit increased therapeutic potency and against which resistance is less likely to develop. Additionally, identifying multiple protein targets is also critical for side-effect prediction. One third of potential therapeutic compounds fail in clinical trials or are later removed from the market due to unacceptable side effects often caused by off-target binding. In the current work, we introduce a multidimensional …

Semantics Centric Solutions For Application And Data Portability In Cloud Computing, Ajith Harshana Ranabahu, Amit P. Sheth

Kno.e.sis Publications

Cloud computing has become one of the key considerations both in academia and industry. Cheap, seemingly unlimited computing resources that can be allocated almost instantaneously and pay-as-you-go pricing schemes are some of the reasons for the success of Cloud computing. The Cloud computing landscape, however, is plagued by many issues hindering adoption. One such issue is vendor lock-in, forcing the Cloud users to adhere to one service provider in terms of data and application logic. Semantic Web has been an important research area that has seen significant attention from both academic and industrial researchers. One key property of Semantic Web …

A Reasonable Semantic Web, Pascal Hitzler, Frank Van Harmelen

Computer Science and Engineering Faculty Publications

The realization of Semantic Web reasoning is central to substantiating the Semantic Web vision. However, current mainstream research on this topic faces serious challenges, which forces us to question established lines of research and to rethink the underlying approaches. We argue that reasoning for the Semantic Web should be understood as "shared inference," which is not necessarily based on deductive methods. Model-theoretic semantics (and sound and complete reasoning based on it) functions as a gold standard, but applications dealing with large-scale and noisy data usually cannot afford the required runtimes. Approximate methods, including deductive ones, but also approaches based on …

Approximate Instance Retrieval On Ontologies, Tuvshintur Tserendorj, Stephan Grimm, Pascal Hitzler

Computer Science and Engineering Faculty Publications

With the development of more expressive description logics (DLs) for the Web Ontology Language OWL the question arises how we can properly deal with the high computational complexity for efficient reasoning. In application cases that require scalable reasoning with expressive ontologies, non-standard reasoning solutions such as approximate reasoning are necessary to tackle the intractability of reasoning in expressive DLs. In this paper, we are concerned with the approximation of the reasoning task of instance retrieval on DL knowledge bases, trading correctness of retrieval results for gain of speed. We introduce our notion of an approximate concept extension and we provide …

Nominal Schemas For Integrating Rules And Ontologies, Frederick Maier, Adila A. Krisnadhi, Pascal Hitzler

Computer Science and Engineering Faculty Publications

We propose a description-logic style extension of OWL DL, which includes DL-safe variable SWRL and seamlessly integrates datalog rules. Our language also sports a tractable fragment, which we call ELP 2, covering OWL EL, OWL RL, most of OWL QL, and variable restricted datalog.

Semantic Web – Interoperability, Usability, Applicability, Pascal Hitzler, Krzysztof Janowicz

Computer Science and Engineering Faculty Publications

No abstract provided.

Identifying Protein Complexes From Interaction Networks Based On Clique Percolation And Distance Restriction, Jianxin Wang, Binbin Liu, Min Li, Yi Pan

Computer Science Faculty Publications

Background: Identification of protein complexes in large interaction networks is crucial to understand principles of cellular organization and predict protein functions, which is one of the most important issues in the post-genomic era. Each protein might be subordinate multiple protein complexes in the real protein-protein interaction networks.Identifying overlapping protein complexes from protein-protein interaction networks is a considerable research topic.

Result: As an effective algorithm in identifying overlapping module structures, clique percolation method (CPM) has a wide range of application in social networks and biological networks. However, the recognition accuracy of algorithm CPM is lowly. Furthermore, algorithm CPM is unfit to …

Recent Advances In Clustering Methods For Protein Interaction Networks, Jianxin Wang, Min Li, Youping Deng, Yi Pan

Computer Science Faculty Publications

The increasing availability of large-scale protein-protein interaction data has made it possible to understand the basic components and organization of cell machinery from the network level. The arising challenge is how to analyze such complex interacting data to reveal the principles of cellular organization, processes and functions. Many studies have shown that clustering protein interaction network is an effective approach for identifying protein complexes or functional modules, which has become a major research topic in systems biology. In this review, recent advances in clustering methods for protein interaction networks will be presented in detail. The predictions of protein functions and …

Jane: A New Tool For The Cophylogeny Reconstruction Problem, Chris Conow, Daniel Fielder '11, Yaniv J. Ovadia '10, Ran Libeskind-Hadas

All HMC Faculty Publications and Research

Background

This paper describes the theory and implementation of a new software tool, called Jane, for the study of historical associations. This problem arises in parasitology (associations of hosts and parasites), molecular systematics (associations of orderings and genes), and biogeography (associations of regions and orderings). The underlying problem is that of reconciling pairs of trees subject to biologically plausible events and costs associated with these events. Existing software tools for this problem have strengths and limitations, and the new Jane tool described here provides functionality that complements existing tools.

Results

The Jane software tool uses a polynomial time dynamic …

Sensor Data And Perception: Can Sensors Play 20 Questions, Cory Andrew Henson

Kno.e.sis Publications

Currently, there are many sensors collecting information about our environment, leading to an overwhelming number of observations that must be analyzed and explained in order to achieve situation awareness. As perceptual beings, we are also constantly inundated with sensory data, yet we are able to make sense of our environment with relative ease. Why is the task of perception so easy for us, and so hard for machines; and could this have anything to do with how we play the game 20 Questions?

Twitris 2.0 : Semantically Empowered System For Understanding Perceptions From Social Data, Ashutosh Sopan Jadhav, Hemant Purohit, Pavan Kapanipathi, Pramod Anantharam, Ajith H. Ranabahu, Vinh Nguyen, Pablo N. Mendes, Alan Gary Smith, Michael Cooney, Amit P. Sheth

Kno.e.sis Publications

We present Twitris 2.0, a Semantic Web application that facilitates understanding of social perceptions by Semantics-based processing of massive amounts of event-centric data. Twitris 2.0 addresses challenges in large scale processing of social data, preserving spatio-temporal-thematic properties. Twitris 2.0 also covers context based semantic integration of multiple Web resources and expose semantically enriched social data to the public domain. Semantic Web technologies enable the systematic integration and analysis abilities.

Automated Isolation Of Translational Efficiency Bias That Resists The Confounding Effect Of Gc(At)-Content, Douglas W. Raiford, Dan E. Krane, Travis E. Doom, Michael L. Raymer

Kno.e.sis Publications

Genomic sequencing projects are an abundant source of information for biological studies ranging from the molecular to the ecological in scale; however, much of the information present may yet be hidden from casual analysis. One such information domain, trends in codon usage, can provide a wealth of information about an organism's genes and their expression. Degeneracy in the genetic code allows more than one triplet codon to code for the same amino acid, and usage of these codons is often biased such that one or more of these synonymous codons is preferred. Detection of this bias is an important tool …

Loqus: Linked Open Data Sparql Querying System, Prateek Jain, Kunal Verma, Peter Z. Yeh, Pascal Hitzler, Amit P. Sheth

Kno.e.sis Publications

The LOD cloud is gathering a lot of momentum, with the number of contributors growing manifold. Many prominent data providers have submitted and linked their data to other dataset with the help of manual mappings. The potential of the LOD cloud is enormous ranging from challenging AI issues such as open domain question answering to automated knowledge discovery. We believe that there is not enough technology support available to effectively query the LOD cloud. To this effect, we present a system called Linked Open Data SPARQL Querying System (LOQUS), which automatically maps users queries written in terms of a conceptual …

Computing For The Human Experience: Semantics-Empowered Sensors, Services, And Social Computing On The Ubiquitous Web, Amit P. Sheth

Kno.e.sis Publications

People are on the verge of an era in which the human experience can be enriched in ways they couldn't have imagined two decades ago. Rather than depending on a single technology, people progressed with several whose semantics-empowered convergence and integration will enable us to capture, understand, and reapply human knowledge and intellect. Such capabilities will consequently elevate our technological ability to deal with the abstractions, concepts, and actions that characterize human experiences. This will herald computing for human experience (CHE). The CHE vision is built on a suite of technologies that serves, assists, and cooperates with humans to nondestructively …

A Qualitative Examination Of Topical Tweet And Retweet Practices, Meenakshi Nagarajan, Hemant Purohit, Amit P. Sheth

Kno.e.sis Publications

This work contributes to the study of retweet behavior on Twitter surrounding real-world events. We analyze over a million tweets pertaining to three events, present general tweet properties in such topical datasets and qualitatively analyze the properties of the retweet behavior surrounding the most tweeted/viral content pieces. Findings include a clear relationship between sparse/dense retweet patterns and the content and type of a tweet itself; suggesting the need to study content properties in link-based diffusion models.

A Study In Hadoop Streaming With Matlab For Nmr Data Processing, Kalpa Gunaratna, Paul E. Anderson, Ajith Harshana Ranabahu, Amit P. Sheth

Kno.e.sis Publications

Applying Cloud computing techniques for analyzing large data sets has shown promise in many data-driven scientific applications. Our approach presented here is to use Cloud computing for Nuclear Magnetic Resonance (NMR)data analysis which normally consists of large amounts of data. Biologists often use third party or commercial software for ease of use. Enabling the capability to use this kind of software in a Cloud will be highly advantageous in many ways. Scripting languages especially designed for clouds may not have the flexibility biologists need for their purposes. Although this is true, they are familiar with special software packages that allow …

Power Of Clouds In Your Pocket: An Efficient Approach For Cloud Mobile Hybrid Application Development, Ashwin Manjunatha, Ajith Harshana Ranabahu, Amit P. Sheth, Krishnaprasad Thirunarayan

Kno.e.sis Publications

The advancements in computing have resulted in a boom of cheap, ubiquitous, connected mobile devices as well as seemingly unlimited, utility style, pay as you go computing resources, commonly referred to as Cloud computing. However, taking full advantage of this mobile and cloud computing landscape, especially for the data intensive domains has been hampered by the many heterogeneities that exist in the mobile space as well as the Cloud space. Our research focuses on exploiting the capabilities of the mobile and cloud landscape by defining a new class of applications called cloud mobile hybrid (CMH) applications and a Domain Specific …

Continuous Semantics To Analyze Real-Time Data, Amit P. Sheth, Christopher Thomas, Pankaj Mehra

Kno.e.sis Publications

Increasingly we are presented with dynamic domains involved in social, mobile, and sensor webs. Such domains are spontaneous (arising suddenly), follow a period of rapid evolution, involving real-time or near real-time data, involve many distributed participants and diverse viewpoints involving topical or contentious subjects, and involve feature context colored by local knowledge and sociocultural backgrounds. This article present continuous semantics can help us model such dynamic domains and analyze the related real-time data. Capabilities include crating dynamic domain model by mining social data, and using dynamic models for semantic analysis of real-time data.

Sensor Discovery On Linked Data, Josh Pschorr, Cory Andrew Henson, Harshal Kamlesh Patni, Amit P. Sheth

Kno.e.sis Publications

There has been a drive recently to make sensor data accessible on the Web. However, because of the vast number of sensors collecting data about our environment, finding relevant sensors on the Web is a non-trivial challenge. In this paper, we present an approach to discovering sensors through a standard service interface over Linked Data. This is accomplished with a semantic sensor network middleware that includes a sensor registry on Linked Data and a sensor discovery service that extends the OGC Sensor Web Enablement. With this approach, we are able to access and discover sensors that are positioned near named-locations …

Understanding Events Through Analysis Of Social Media, Amit P. Sheth, Hemant Purohit, Ashutosh Sopan Jadhav, Pavan Kapanipathi, Lu Chen

Kno.e.sis Publications

Users are sharing vast amounts of social data through social networking platforms accessible by Web and increasingly via mobile devices. This opens an exciting opportunity to extract social perceptions as well as obtain insights relevant to events around us. We discuss the significant need and opportunity for analyzing event-centric user generated content on social networks, present some of the technical challenges and our approach to address them. This includes aggregating social data related to events of interest, along with Web resources (news, Wikipedia pages, multimedia) related to an event of interest, and supporting analysis along spatial, temporal, thematic, and sentiment …

Provenance Context Entity (Pace): Scalable Provenance Tracking For Scientific Rdf Data, Satya S. Sahoo, Olivier Bodenreider, Pascal Hitzler, Amit P. Sheth, Krishnaprasad Thirunarayan

Kno.e.sis Publications

The Resource Description Framework (RDF) format is being used by a large number of scientific applications to store and disseminate their datasets. The provenance information, describing the source or lineage of the datasets, is playing an increasingly significant role in ensuring data quality, computing trust value of the datasets, and ranking query results. Current provenance tracking approaches using the RDF reification vocabulary suffer from a number of known issues, including lack of formal semantics, use of blank nodes, and application-dependent interpretation of reified RDF triples. In this paper, we introduce a new approach called Provenance Context Entity (PaCE) that uses …

Mobicloud - Making Clouds Reachable: A Toolkit For Easy And Efficient Development Of Customized Cloud Mobile Hybrid Applications, Ashwin Manjunatha, Ajith Harshana Ranabahu, Amit P. Sheth, Krishnaprasad Thirunarayan

Kno.e.sis Publications

The advancements in computing have resulted in a boom of cheap, ubiquitous, connected mobile devices, as well as seemingly unlimited, utility style, pay as you go computing resources, commonly referred to as Cloud computing. However, taking full advantage of this mobile and cloud computing landscape, especially for the data intensive domains, has been hampered by the many heterogeneities that exist in the mobile space, as well as the Cloud space. Our research attempts to exploit the capabilities of the mobile and cloud landscape by introducing MobiCloud, an online toolkit to efficiently develop Cloud-mobile hybrid (CMH) applications. We define a CMH …

From Questions To Effective Answers: On The Utility Of Knowledge-Driven Querying Systems For Life Sciences Data, Amir H. Asiaee, Prashant Doshi, Todd Minning, Satya S. Sahoo, Priti Parikh, Amit P. Sheth, Rick L. Tarleton

Kno.e.sis Publications

We compare two distinct approaches for querying data in the context of the life sciences. The first approach utilizes conventional databases to store the data and intuitive form-based interfaces to facilitate easy querying of the data. These interfaces could be seen as implementing a set of 'pre-canned' queries commonly used by the life science researchers that we study. The second approach is based on semantic Web technologies and is knowledge (model) driven. It utilizes a large OWL ontology and same datasets as before but associated as RDF instances of the ontology concepts. An intuitive interface is provided that allows the …