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Axonal Activity In Vivo: Technical Considerations And Implications For The Exploration Of Neural Circuits In Freely Moving Animals, Jeremy M. Barry
Axonal Activity In Vivo: Technical Considerations And Implications For The Exploration Of Neural Circuits In Freely Moving Animals, Jeremy M. Barry
Dartmouth Scholarship
While extracellular somatic action potentials from freely moving rats have been well characterized, axonal activity has not. We have recently reported extracellular tetrode recordings of short duration waveforms (SDWs) with an average peak-trough duration less than 172μs. These waveforms have significantly shorter duration than somatic action potentials and tend to be triphasic. The present review discusses further data that suggests SDWs are representative of axonal activity, how this characterization allows for more accurate classification of somatic activity and could serve as a means of exploring signal integration in neural circuits. The review also discusses how axons may function as more …