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Full-Text Articles in Life Sciences
Identification And Characterization Of Barrier Insulator Activity In The T-Cell Receptor Alpha Locus Control Region, Gayathri Devi Raghupathy
Identification And Characterization Of Barrier Insulator Activity In The T-Cell Receptor Alpha Locus Control Region, Gayathri Devi Raghupathy
Dissertations, Theses, and Capstone Projects
Genes of different spatiotemporal expression profiles are often juxtaposed in the genome. This organization raises risks of cross-regulatory influences from neighboring genes; for instance heterochromatin can spread over euchromatin or long-range acting enhancers can inappropriately activate genes. Gene regulatory elements such as Locus Control Regions (LCR) and Insulators prevent such cross-communications and allow for normal gene expression patterns. In transgenic systems, LCRs limit influences from surrounding chromatin by providing site-of-integration independent and specific spatiotemporal expression upon a linked transgene. The field’s understanding of the ability of an LCR to overcome chromatin influences and allow site-of-integration independent expression is minimal. Interestingly, …
Molecular Interactions Between Pvt1 Transcripts And C-Myc, Onayemi Titilayo Onagoruwa
Molecular Interactions Between Pvt1 Transcripts And C-Myc, Onayemi Titilayo Onagoruwa
Theses and Dissertations
This study focused on the molecular relationships between PVT1 exons 4A, 4B, 9 and c-Myc in prostate cancer. Data showed significant regulatory interactions between these exons and c-Myc which is strongest between PVT1 exon 9 and c-Myc. This will likely have implications for PCa where PVT1 and c-Myc are dysregulated.