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Full-Text Articles in Life Sciences
64cu-Bevacizumab As A Better Pet Imaging Agent In Detecting Breast Cancer In Mda-Mb-231 Orthotopic And Bone Metastasis Mice Model Compared To 18fdg, Keya De Mukhopadhyay, Ting-Tung Chang, William Phillips, Lu-Zhe Sun, Beth Goins
64cu-Bevacizumab As A Better Pet Imaging Agent In Detecting Breast Cancer In Mda-Mb-231 Orthotopic And Bone Metastasis Mice Model Compared To 18fdg, Keya De Mukhopadhyay, Ting-Tung Chang, William Phillips, Lu-Zhe Sun, Beth Goins
American Journal of Applied Bio-Technology Research (AJABTR)
Developing new imaging agents help in the detection of breast cancer with better sensitivity and specificity and it improves the patient outcomes significantly. This provides the physicians with improved early detection of breast cancer during the routine screening process and has the potential to help the surgeons in identifying the tumor margins more accurately for surgical resection. In this study, we evaluate the efficiency of 64Cu-bevacizumab to successfully detect the small tumors (5mm), large tumors (15mm) and metastatic sites in MDA-MB-231 breast cancer mouse models compared to 18FDG and conclude that 64Cu-bevacizumab is a promising PET (positron …
Chemical Epitope Targeting: Review Of A Novel Screening Technology, Qurrat Ul-Ain, Rene Kandler, Dylan Gillespie, Arundhati Nag
Chemical Epitope Targeting: Review Of A Novel Screening Technology, Qurrat Ul-Ain, Rene Kandler, Dylan Gillespie, Arundhati Nag
Scholarly Undergraduate Research Journal at Clark (SURJ)
Chemical Epitope Targeting is a novel technology developed for designing peptide ligands with high affinity and specificity against specific regions of a protein that may be inaccessible to small molecules or antibodies. In this review, we summarize the key steps and significant applications of this technology. Operating on the same principles as antibody-antigen interactions, this technique involves chemically synthesizing the region of interest on the protein, called the epitope, as a polypeptide with a biotin detection tag and a strategically placed alkyne or azide presenting amino acid. The constructed epitope is screened against a comprehensive linear or cyclic One Bead …