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Construction And Characterization Of Non-Toxic Bacterial Enterotoxins As Vaccine Adjuvants, Lavanya Vempati
Construction And Characterization Of Non-Toxic Bacterial Enterotoxins As Vaccine Adjuvants, Lavanya Vempati
Boise State University Theses and Dissertations
The development of adjuvants that can promote the delivery of purified subunit vaccines by mucosal routes, such as the nose or the mouth, is recognized as a top priority for vaccine research. The bacterial enterotoxins; cholera toxin (CT) and E.coli heat-labile toxin (LTI), have long been recognized as powerful adjuvants with the ability to stimulate specific immune responses to co-administered antigens when delivered to mucosal surfaces. Shiga toxin 1 (ST1) and pertussis toxin (PT) are structurally homologous bacterial toxins secreted by Escherichia coli 0157:H7 and Bordetella pertussis respectively. ST1 and PT also have reported adjuvant activity but it is less …
Making More Sensitive Dna Sensors Using Gold Nanoparticles And Dna-Based Amplification Networks, Herbert M. Huttanus
Making More Sensitive Dna Sensors Using Gold Nanoparticles And Dna-Based Amplification Networks, Herbert M. Huttanus
Boise State University Theses and Dissertations
This study focuses on the use of gold nanoparticles with DNA-based signal amplification as a detection method for low concentrations of DNA bio-markers. Biotechnology is a rapidly evolving field with primarily medical applications. Early detection is a challenging process for some cancers and other diseases yet is so critical to successful treatment. Increasingly sensitive detection techniques are being developed, but the current gold standard for detecting nucleotide biomarkers at low concentrations is polymerase chain reaction. While this technique is sensitive, it requires the use of active enzymes, a thermocycler, and trained personnel working in a clean environment, and is thus …