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Full-Text Articles in Life Sciences
Modulatory Action By The Serotonergic System: Behavior And Neurophysiology In Drosophila Melanogaster, Zana R Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L. Cooper
Modulatory Action By The Serotonergic System: Behavior And Neurophysiology In Drosophila Melanogaster, Zana R Majeed, Esraa Abdeljaber, Robin Soveland, Kristin Cornwell, Aubrey Bankemper, Felicitas Koch, Robin L. Cooper
Biology Faculty Publications
Serotonin modulates various physiological processes and behaviors. This study investigates the role of 5-HT in locomotion and feeding behaviors as well as in modulation of sensory-motor circuits. The 5-HT biosynthesis was dysregulated by feeding Drosophila larvae 5-HT, a 5-HT precursor, or an inhibitor of tryptophan hydroxylase during early stages of development. The effects of feeding fluoxetine, a selective serotonin reuptake inhibitor, during early second instars were also examined. 5-HT receptor subtypes were manipulated using RNA interference mediated knockdown and 5-HT receptor insertional mutations. Moreover, synaptic transmission at 5-HT neurons was blocked or enhanced in both larvae and adult flies. The …
Serotonergic Modulation Of The Crayfish Hindgut: Effects On Hindgut Contractility And Regulation Of Serotonin On Hindgut, Barbara Ellen Musolf
Serotonergic Modulation Of The Crayfish Hindgut: Effects On Hindgut Contractility And Regulation Of Serotonin On Hindgut, Barbara Ellen Musolf
Biology Dissertations
Serotonin (5-hydroxytryptamine, 5-HT) has long been associated with the vertebrate gut and is an important neuromodulator of crustacean foregut. This dissertation presents evidence that 5-HT initiated peristalsis in crayfish hindgut and enhanced the power of contractions in caudal regions of the hindgut. 5-HT receptor immunoreactivity studies showed that the two identified crustacean 5-HT receptors, 5-HT1α and 5-HT2β are present on the hindgut in different and distinctive patterns. 5-HT immunoreactivity (5-HT-ir) studies revealed that the fibers from central neurons found on the hindgut showed a broad range of 5-HT-ir intensity, which led to the hypothesis that they borrowed 5-HT. …