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Investigation Of The Localization And Expression Of The G-Protein Coupled Receptor Fshr-1 In C. Elegans Neurons, Kyle Cherry
Investigation Of The Localization And Expression Of The G-Protein Coupled Receptor Fshr-1 In C. Elegans Neurons, Kyle Cherry
Undergraduate Honors Thesis Collection
Neurons communicate at specialized junctions called synapses. Synaptic transmission occurs when presynaptically released neurotransmitters bind to receptors either continuing (excitatory) or stopping (inhibitory) the signal in the postsynaptic cell. Excitatory to inhibitory (E:I) balance is critical for proper neurological function. This balance is achieved through the function of various proteins such as the ubiquitin ligase, the anaphase promoting complex (APC). My thesis project focuses on one potential APC substrate, a G protein-coupled receptor called FSHR-1, and its role in synaptic transmission at the neuromuscular junction (NMJ) in Caenorhabditis elegans. Previous data from our lab and others showed that worms lacking …