Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Publication
- Publication Type
Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Analyzing And Modeling The Dysfunction Of Inhibitory Neurons In Alzheimer’S Disease, Carlos Perez, Jokubas Ziburkus, Ghamim Ullah
Analyzing And Modeling The Dysfunction Of Inhibitory Neurons In Alzheimer’S Disease, Carlos Perez, Jokubas Ziburkus, Ghamim Ullah
Physics Faculty Publications
Alzheimer’s disease (AD) is characterized by the abnormal proteolytic processing of amyloid precursor protein, resulting in increased production of a self-aggregating form of beta amyloid (Aβ). Several lines of work on AD patients and transgenic mice with high Aβ levels exhibit altered rhythmicity, aberrant neuronal network activity and hyperexcitability reflected in clusters of hyperactive neurons, and spontaneous epileptic activity. Recent studies highlight that abnormal accumulation of Aβ changes intrinsic properties of inhibitory neurons, which is one of the main reasons underlying the impaired network activity. However, specific cellular mechanisms leading to interneuronal dysfunction are not completely …
Copper Oxide Nanoparticles Impact Several Toxicological Endpoints And Cause Neurodegeneration In Caenorhabditis Elegans, Michael Joseph Mashock, Tyler Zanon, Anthony D. Kappell, Lisa N. Petrella, Erik C. Andersen, Krassimira R. Hristova
Copper Oxide Nanoparticles Impact Several Toxicological Endpoints And Cause Neurodegeneration In Caenorhabditis Elegans, Michael Joseph Mashock, Tyler Zanon, Anthony D. Kappell, Lisa N. Petrella, Erik C. Andersen, Krassimira R. Hristova
Biological Sciences Faculty Research and Publications
Engineered nanoparticles are becoming increasingly incorporated into technology and consumer products. In 2014, over 300 tons of copper oxide nanoparticles were manufactured in the United States. The increased production of nanoparticles raises concerns regarding the potential introduction into the environment or human exposure. Copper oxide nanoparticles commonly release copper ions into solutions, which contribute to their toxicity. We quantified the inhibitory effects of both copper oxide nanoparticles and copper sulfate on C. elegans toxicological endpoints to elucidate their biological effects. Several toxicological endpoints were analyzed in C. elegans, including nematode reproduction, feeding behavior, and average body length. We examined three …
Raised Intracellular Calcium Contributes To Ischemia-Induced Depression Of Evoked Synaptic Transmission, Shirin Jalini, Hui Ye, Alexander A. Tonkikh, Milton P. Charlton, Peter L. Carlen
Raised Intracellular Calcium Contributes To Ischemia-Induced Depression Of Evoked Synaptic Transmission, Shirin Jalini, Hui Ye, Alexander A. Tonkikh, Milton P. Charlton, Peter L. Carlen
Biology: Faculty Publications and Other Works
Oxygen-glucose deprivation (OGD) leads to depression of evoked synaptic transmission, for which the mechanisms remain unclear. We hypothesized that increased presynaptic [Ca2+]i during transient OGD contributes to the depression of evoked field excitatory postsynaptic potentials (fEPSPs). Additionally, we hypothesized that increased buffering of intracellular calcium would shorten electrophysiological recovery after transient ischemia. Mouse hippocampal slices were exposed to 2 to 8 min of OGD. fEPSPs evoked by Schaffer collateral stimulation were recorded in the stratum radiatum, and whole cell current or voltage clamp recordings were performed in CA1 neurons. Transient ischemia led to increased presynaptic [Ca2+ …
Investigation Of The Localization And Expression Of The G-Protein Coupled Receptor Fshr-1 In C. Elegans Neurons, Kyle Cherry
Investigation Of The Localization And Expression Of The G-Protein Coupled Receptor Fshr-1 In C. Elegans Neurons, Kyle Cherry
Undergraduate Honors Thesis Collection
Neurons communicate at specialized junctions called synapses. Synaptic transmission occurs when presynaptically released neurotransmitters bind to receptors either continuing (excitatory) or stopping (inhibitory) the signal in the postsynaptic cell. Excitatory to inhibitory (E:I) balance is critical for proper neurological function. This balance is achieved through the function of various proteins such as the ubiquitin ligase, the anaphase promoting complex (APC). My thesis project focuses on one potential APC substrate, a G protein-coupled receptor called FSHR-1, and its role in synaptic transmission at the neuromuscular junction (NMJ) in Caenorhabditis elegans. Previous data from our lab and others showed that worms lacking …