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Articles 1 - 30 of 65
Full-Text Articles in Life Sciences
A High-Efficiency Gene Silencing In Plants Using Two-Hit Asymmetrical Artificial Micrornas, Sachin Teotia, Xiaoran Wang, Na Zhou, Mengmeng Wang, Haiping Liu, Jun Qin, Dianwei Han, Chingwen Li, Christine E. Li, Shangjin Pan, Haifeng Tang, Wenjun Kang, Zhanhui Zhang, Xiaoqing Tang, Ting Peng, Guiliang Tang
A High-Efficiency Gene Silencing In Plants Using Two-Hit Asymmetrical Artificial Micrornas, Sachin Teotia, Xiaoran Wang, Na Zhou, Mengmeng Wang, Haiping Liu, Jun Qin, Dianwei Han, Chingwen Li, Christine E. Li, Shangjin Pan, Haifeng Tang, Wenjun Kang, Zhanhui Zhang, Xiaoqing Tang, Ting Peng, Guiliang Tang
Michigan Tech Publications
MicroRNAs (miRNAs) are small non-coding RNA molecules that play a crucial role in gene regulation. They are produced through an enzyme-guided process called dicing and have an asymmetrical structure with two nucleotide overhangs at the 3' ends. Artificial microRNAs (amiRNAs or amiRs) are designed to mimic the structure of miRNAs and can be used to silence specific genes of interest. Traditionally, amiRNAs are designed based on an endogenous miRNA precursor with certain mismatches at specific positions to increase their efficiency. In this study, the authors modified the highly expressed miR168a in Arabidopsis thaliana by replacing the single miR168 stem-loop / …
Impacts Of Microrna-483 On Human Diseases, Katy Matson, Aaron B. Macleod, Nirali Mehta, Ellie Sempek, Xiaoqing Tang
Impacts Of Microrna-483 On Human Diseases, Katy Matson, Aaron B. Macleod, Nirali Mehta, Ellie Sempek, Xiaoqing Tang
Michigan Tech Publications
MicroRNAs (miRNAs) are short non-coding RNA molecules that regulate gene expression by targeting specific messenger RNAs (mRNAs) in distinct cell types. This review provides a com-prehensive overview of the current understanding regarding the involvement of miR-483-5p and miR-483-3p in various physiological and pathological processes. Downregulation of miR-483-5p has been linked to numerous diseases, including type 2 diabetes, fatty liver disease, diabetic nephropathy, and neurological injury. Accumulating evidence indicates that miR-483-5p plays a crucial protective role in preserving cell function and viability by targeting specific transcripts. Notably, elevated levels of miR-483-5p in the bloodstream strongly correlate with metabolic risk factors and …
Deconstructed Plastic Substrate Preferences Of Microbial Populations From The Natural Environment, Lindsay I. Putman, Laura G. Schaerer, Ruochen Wu, Daniel G. Kulas, Ali Zolghadr, Rebecca Ong, David Shonnard, Stephen Techtmann
Deconstructed Plastic Substrate Preferences Of Microbial Populations From The Natural Environment, Lindsay I. Putman, Laura G. Schaerer, Ruochen Wu, Daniel G. Kulas, Ali Zolghadr, Rebecca Ong, David Shonnard, Stephen Techtmann
Michigan Tech Publications
Over half of the world's plastic waste is landfilled, where it is estimated to take hundreds of years to degrade. Given the continued use and disposal of plastic products, it is vital that we develop fast and effective ways to utilize plastic waste. Here, we explore the potential of tandem chemical and biological processing to process various plastics quickly and effectively. Four samples of compost or sediment were used to set up enrichment cultures grown on mixtures of compounds, including disodium terephthalate and terephthalic acid (monomers of polyethylene terephthalate), compounds derived from the chemical deconstruction of polycarbonate, and pyrolysis oil …
Editorial: Gulf Of Mexico Estuaries: Ecology Of The Nearshore And Coastal Ecosystems Impacted By The Deepwater Horizon Oil Spill, Charles W. Martin, Paola C. López-Duarte, Jill A. Olin, Brian J. Roberts
Editorial: Gulf Of Mexico Estuaries: Ecology Of The Nearshore And Coastal Ecosystems Impacted By The Deepwater Horizon Oil Spill, Charles W. Martin, Paola C. López-Duarte, Jill A. Olin, Brian J. Roberts
Michigan Tech Publications
No abstract provided.
Chemically Catalyzed Phytoextraction For Sustainable Cleanup Of Soil Lead Contamination In A Community Garden In Jersey City, New Jersey, Zhiming Zhang, Dibyendu Sarkar, Frances Levy, Rupali Datta
Chemically Catalyzed Phytoextraction For Sustainable Cleanup Of Soil Lead Contamination In A Community Garden In Jersey City, New Jersey, Zhiming Zhang, Dibyendu Sarkar, Frances Levy, Rupali Datta
Michigan Tech Publications
Soil lead (Pb) contamination in Pb paint-contaminated homes is a serious health risk in urban areas. Phytoextraction is a green and sustainable technology for soil Pb remediation, but its efficiency depends on the geochemical partitioning of Pb in soil. Following successful laboratory, greenhouse, and panel experiments, a field study was conducted to demonstrate the effectiveness of a chemically catalyzed phytoextraction model for Pb removal. A biodegradable chelating agent, ethylenediaminedisuccinic acid (EDDS) was applied during Pb phytoextraction by vetiver grass (Chrysopogon zizanioides) in a Pb-contaminated community garden in Jersey City, New Jersey. Results showed that soil Pb concentration was reduced from …
Mechanical Properties And Morphological Alterations In Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes, James Dolgin, Samerender Nagam Hanumantharao, Stephen Farias, Carl G. Simon, Smitha Rao
Mechanical Properties And Morphological Alterations In Fiber-Based Scaffolds Affecting Tissue Engineering Outcomes, James Dolgin, Samerender Nagam Hanumantharao, Stephen Farias, Carl G. Simon, Smitha Rao
Michigan Tech Publications
Electrospinning is a versatile tool used to produce highly customizable nonwoven nanofiber mats of various fiber diameters, pore sizes, and alignment. It is possible to create electrospun mats from synthetic polymers, biobased polymers, and combinations thereof. The post-processing of the end products can occur in many ways, such as cross-linking, enzyme linking, and thermal curing, to achieve enhanced chemical and physical properties. Such multi-factor tunability is very promising in applications such as tissue engineering, 3D organs/organoids, and cell differentiation. While the established methods involve the use of soluble small molecules, growth factors, stereolithography, and micro-patterning, electrospinning involves an inexpensive, labor …
Optimized Production Of Second-Generation Bioethanol From A Spent C4 Grass: Vetiver (Chrysopogon Zizanioides), Sameer Neve, Dibyendu Sarkar, Zhiming Zhang, Rupali Datta
Optimized Production Of Second-Generation Bioethanol From A Spent C4 Grass: Vetiver (Chrysopogon Zizanioides), Sameer Neve, Dibyendu Sarkar, Zhiming Zhang, Rupali Datta
Michigan Tech Publications
Vetiver grass (Chrysopogon zizanioides) is well-known for its contaminant phytoextraction potential and its capacity to reduce soil erosion, owing to its massive, dense root system. However, the shoots are not major contributors to either of these processes, and are either not utilized at all or they become part of the waste stream. It is well-recognized that lignocellulosic biomass can serve as a source of raw material to produce second-generation bioethanol. This study investigated the simultaneous saccharification and fermentation (SSF) of acid–alkali pretreated vetiver (VG) shoots by Saccharomyces cerevisiae. Vetiver shoots were obtained from three sources: (1) shoots from VG grown …
An Updated Nomenclature For Plant Ribosomal Protein Genes, M Regina Scarpin, Michael Busche, Ryan E. Martinez, Lisa C. Harper, Leonore Reiser, Dóra Szakonyi, Catharina Merchante, Ting Lan, Wei Xiong, Beixin Mo, Guiliang Tang, Xuemei Chen, Julia Bailey-Serres, Karen S. Browning, Jacob O. Brunkard
An Updated Nomenclature For Plant Ribosomal Protein Genes, M Regina Scarpin, Michael Busche, Ryan E. Martinez, Lisa C. Harper, Leonore Reiser, Dóra Szakonyi, Catharina Merchante, Ting Lan, Wei Xiong, Beixin Mo, Guiliang Tang, Xuemei Chen, Julia Bailey-Serres, Karen S. Browning, Jacob O. Brunkard
Michigan Tech Publications
No abstract provided.
Removal Of Heavy Metals From Stormwater Runoff Using Granulated Drinking Water Treatment Residuals, Viravid Na Nagara, Dibyendu Sarkar, Evert J. Elzinga, Rupali Datta
Removal Of Heavy Metals From Stormwater Runoff Using Granulated Drinking Water Treatment Residuals, Viravid Na Nagara, Dibyendu Sarkar, Evert J. Elzinga, Rupali Datta
Michigan Tech Publications
Stormwater runoff is a significant source of heavy metals, including cadmium (Cd), chromium (Cr), and nickel (Ni), which pose ecological and human health problems. Various filter media have been evaluated for heavy metal removal from stormwater via adsorption, most involving chemical- or energy-intensive processes. Aluminum-based drinking water treatment residuals (WTR), a non-hazardous byproduct of drinking water treatment, are an inexpensive sorbent for heavy metals. However, the low permeability of WTR is a problem and requires mixing with sand and carbon materials to improve flow; but such amendments also reduce its sorption capacity. To overcome this problem, a granulated WTR sorbent …
In-Vitro Cell Culture Model To Determine Toxic Effects Of Soil Arsenic Due To Direct Dermal Exposure, Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, Smitha Rao
In-Vitro Cell Culture Model To Determine Toxic Effects Of Soil Arsenic Due To Direct Dermal Exposure, Manas Warke, Madeline English, Laura De Marchi, Rohan Deep Sarkar, Srinivas Kannan, Rupali Datta, Smitha Rao
Michigan Tech Publications
Arsenic (As) is one of the most toxic environmental pollutants, classified as a Class I carcinogen. Anthropogenic activities have led to an increase in As contamination of soils. Using animal models to study the health impacts of As is time and cost-prohibitive, hence attempts have been made to develop in-vitro cell culture models. However, most studies so far have not represented realistic environmental exposure conditions. We exposed Human Immortalized Keratinocyte (HaCaT) and Primary Human Dermal Fibroblasts (HDFa) cells to the water-soluble fraction of arsenic extracted from As spiked Immokalee soil to study the effect of soil As on skin cells. …
Correlation Of Phosphorus Adsorption With Chemical Properties Of Aluminum-Based Drinking Water Treatment Residuals Collected From Various Parts Of The United States, Roxana Rahmati, Virinder Sidhu, Rosita Nunez, Rupali Datta, Dibyendu Sarkar
Correlation Of Phosphorus Adsorption With Chemical Properties Of Aluminum-Based Drinking Water Treatment Residuals Collected From Various Parts Of The United States, Roxana Rahmati, Virinder Sidhu, Rosita Nunez, Rupali Datta, Dibyendu Sarkar
Michigan Tech Publications
Over the past several decades, the value of drinking water treatment residuals (WTRs), a byproduct of the coagulation process during water purification, has been recognized in various environmental applications, including sustainable remediation of phosphorus (P)-enriched soils. Aluminum-based WTRs (Al-WTRs) are suitable adsorbent materials for P, which can be obtained and processed inexpensively. However, given their heterogeneous nature, it is essential to identify an easily analyzable chemical property that can predict the capability of Al-WTRs to bind P before soil amendment. To address this issue, thirteen Al-WTRs were collected from various geographical locations around the United States. The non-hazardous nature of …
Phosphorus And Heavy Metals Removal From Stormwater Runoff Using Granulated Industrial Waste For Retrofitting Catch Basins, Viravid Na Nagara, Dibyendu Sarkar, Rupali Datta
Phosphorus And Heavy Metals Removal From Stormwater Runoff Using Granulated Industrial Waste For Retrofitting Catch Basins, Viravid Na Nagara, Dibyendu Sarkar, Rupali Datta
Michigan Tech Publications
Phosphorus and heavy metals are washed off and transported with stormwater runoff to nearby surface water bodies resulting in environmental and human health risks. Catch basins remain one of the primary gateways through which stormwater runoff and pollutants from urban areas are transported. Retrofitting catch basins to enhance their phosphorus and heavy metal removal can be an effective approach. In this study, aluminum-based water treatment residual (WTR, a non-hazardous byproduct of the water treatment process) was granulated via a green method to serve as a sustainable filter material, called WTR granules, for enhancing the capabilities of catch basins to remove …
The Use Of Non-Model Drosophila Species To Study Natural Variation In Tor Pathway Signaling, Tessa Steenwinkel, Kailee K. Hamre, Thomas Werner
The Use Of Non-Model Drosophila Species To Study Natural Variation In Tor Pathway Signaling, Tessa Steenwinkel, Kailee K. Hamre, Thomas Werner
Michigan Tech Publications
Nutrition and growth are strongly linked, but not much is known about how nutrition leads to growth. To understand the connection between nutrition through the diet, growth, and proliferation, we need to study the phenotypes resulting from the activation and inhibition of central metabolic pathways. One of the most highly conserved metabolic pathways across eukaryotes is the Target of Rapamycin (TOR) pathway, whose primary role is to detect the availability of nutrients and to either induce or halt cellular growth. Here we used the model organism Drosophila melanogaster (D. mel.) and three non-model Drosophila species with different dietary needs, Drosophila …
High Daily And Year-Round Variability In Denitrification And Nitrogen Fixation In A Northern Temperate River, Kevin Nevorski, Amy M. Marcarelli
High Daily And Year-Round Variability In Denitrification And Nitrogen Fixation In A Northern Temperate River, Kevin Nevorski, Amy M. Marcarelli
Michigan Tech Publications
Rates of nitrogen (N) cycling processes like denitrification and dinitrogen (N2) fixation, which together are the primary contributors to N2 flux rates from surface waters, may change at different time scales from seasons to weeks to days. Yet, we know little about the magnitude, mechanisms or drivers of these temporal changes, especially at shorter daily and weekly timescales. Quantifying variation in rates and drivers across temporal scales is essential to understand how nutrient cycling processes operate in aquatic ecosystems and predict how they may respond to shifting seasonal dynamics caused by global change (i.e., earlier snowmelt and extreme weather events). …
Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang
Integrating Deep Learning And Hydrodynamic Modeling To Improve The Great Lakes Forecast, Pengfei Xue, Aditya Wagh, Gangfeng Ma, Yilin Wang, Yongchao Yang, Tao Liu, Chenfu Huang
Michigan Tech Publications
The Laurentian Great Lakes, one of the world’s largest surface freshwater systems, pose a modeling challenge in seasonal forecast and climate projection. While physics-based hydrodynamic modeling is a fundamental approach, improving the forecast accuracy remains critical. In recent years, machine learning (ML) has quickly emerged in geoscience applications, but its application to the Great Lakes hydrodynamic prediction is still in its early stages. This work is the first one to explore a deep learning approach to predicting spatiotemporal distributions of the lake surface temperature (LST) in the Great Lakes. Our study shows that the Long Short-Term Memory (LSTM) neural network, …
Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha
Virucidal N95 Respirator Face Masks Via Ultrathin Surface-Grafted Quaternary Ammonium Polymer Coatings, Mirco Sorci, Tanner D. Fink, Vaishali Sharma, Sneha Singh, Ruiwen Chen, Brigitte L. Arduini, Katharine Dovidenko, Caryn L. Heldt, Edmund F. Palermo, R Helen Zha
Michigan Tech Publications
N95 respirator face masks serve as effective physical barriers against airborne virus transmission, especially in a hospital setting. However, conventional filtration materials, such as nonwoven polypropylene fibers, have no inherent virucidal activity, and thus, the risk of surface contamination increases with wear time. The ability of face masks to protect against infection can be likely improved by incorporating components that deactivate viruses on contact. We present a facile method for covalently attaching antiviral quaternary ammonium polymers to the fiber surfaces of nonwoven polypropylene fabrics that are commonly used as filtration materials in N95 respirators via ultraviolet (UV)-initiated grafting of biocidal …
Classification Of Eurasian Watermilfoil (Myriophyllum Spicatum) Using Drone-Enabled Multispectral Imagery Analysis, Colin Brooks, Amanda Grimm, Amy Marcarelli, Nicholas Marion, Robert Shuchman, Michael Sayers
Classification Of Eurasian Watermilfoil (Myriophyllum Spicatum) Using Drone-Enabled Multispectral Imagery Analysis, Colin Brooks, Amanda Grimm, Amy Marcarelli, Nicholas Marion, Robert Shuchman, Michael Sayers
Michigan Tech Publications
Remote sensing approaches that could identify species of submerged aquatic vegetation (SAV) and measure their extent in lake littoral zones would greatly enhance SAV study and management, especially if these approaches can provide faster or more accurate results than traditional field methods. Remote sensing with multispectral sensors can provide this capability, but SAV identification with this technology must address the challenges of light extinction in aquatic environments where chlorophyll, dissolved organic carbon, and suspended minerals can affect water clarity and the strength of the sensed light signal. Here, we present an uncrewed aerial system (UAS)-enabled methodology to identify the extent …
Mechanobiology In The Comorbidities Of Ehlers Danlos Syndrome, Shaina P. Royer, Sangyoon J. Han
Mechanobiology In The Comorbidities Of Ehlers Danlos Syndrome, Shaina P. Royer, Sangyoon J. Han
Michigan Tech Publications
Ehlers-Danlos Syndromes (EDSs) are a group of connective tissue disorders, characterized by skin stretchability, joint hypermobility and instability. Mechanically, various tissues from EDS patients exhibit lowered elastic modulus and lowered ultimate strength. This change in mechanics has been associated with EDS symptoms. However, recent evidence points toward a possibility that the comorbidities of EDS could be also associated with reduced tissue stiffness. In this review, we focus on mast cell activation syndrome and impaired wound healing, comorbidities associated with the classical type (cEDS) and the hypermobile type (hEDS), respectively, and discuss potential mechanobiological pathways involved in the comorbidities.
Temporal Variation Of Bacterial Community And Nutrients In Tibetan Glacier Snowpack, Yuying Chen, Keshao Liu, Yongqin Liu, Trista J. Vick‐Majors, Feng Wang, Mukan Ji
Temporal Variation Of Bacterial Community And Nutrients In Tibetan Glacier Snowpack, Yuying Chen, Keshao Liu, Yongqin Liu, Trista J. Vick‐Majors, Feng Wang, Mukan Ji
Michigan Tech Publications
The Tibetan Plateau harbors the largest number of glaciers outside the polar regions, which are the source of several major rivers in Asia. These glaciers are also major sources of nutrients for downstream ecosystems, while there is a little amount of data available on the nutrient transformation processes on the glacier surface. Here, we monitored the carbon and nitrogen concentration changes in a snowpit following a snowfall in the Dunde Glacier of the Tibetan Plateau. The association of carbon and nitrogen changes with bacterial community dynamics was investigated in the surface and subsurface snow (depth at 0–15 and 15–30 cm, …
Health Risk From Toxic Metals In Wild Rice Grown In Copper Mining-Impacted Sediments, Rohan Deep Sarkar, Zhiming Zhang, Manas Warke, Rupali Datta
Health Risk From Toxic Metals In Wild Rice Grown In Copper Mining-Impacted Sediments, Rohan Deep Sarkar, Zhiming Zhang, Manas Warke, Rupali Datta
Michigan Tech Publications
Northern wild rice is of great dietary and cultural importance to the Native American population in the Upper Peninsula of Michigan. Millions of tons of mine tailings were discharged into Lake Superior and other inland lakes during the copper mining boom in the early 20th century in this area. This includes L’Anse Bay, located within the Keweenaw Bay Indian Community (KBIC) reservation. Since wild rice restoration is being encouraged by the KBIC, we investigated the distribution of toxic metals in sediments, water, and wild rice and their potential impact on human health from two locations. Sand Point sloughs on L’Anse …
Draft Genome Sequencing Of Three Glutaraldehyde-Tolerant Bacteria From Produced Water From Hydraulic Fracturing, Stephen Techtmann, Andrew L. Baldwin, Dotun Aluko, Justin Andersen, Cole Becker, Grace Chandler, Steve Forgrave, Madelyn Jones, Ina Klasner, Jared Martini, Noah Mason, Ryleigh Parsons, Nick Peterson, Erik Reynolds, Lydia Schroeder
Draft Genome Sequencing Of Three Glutaraldehyde-Tolerant Bacteria From Produced Water From Hydraulic Fracturing, Stephen Techtmann, Andrew L. Baldwin, Dotun Aluko, Justin Andersen, Cole Becker, Grace Chandler, Steve Forgrave, Madelyn Jones, Ina Klasner, Jared Martini, Noah Mason, Ryleigh Parsons, Nick Peterson, Erik Reynolds, Lydia Schroeder
Michigan Tech Publications
Here, we report the draft genome sequence of three glutaraldehyde-resistant isolates from produced water from hydraulic fracturing operations. The three strains were identified as sp. strain G11, sp. strain G15, and sp. strain G16. The genome sequences of these isolates will provide insights into biocide resistance in hydraulic fracturing operations.
Butterfly Eyespots Evolved Via Cooption Of An Ancestral Gene-Regulatory Network That Also Patterns Antennae, Legs, And Wings, Suriya Narayanan Murugesan, Heidi Connahs, Yuji Matsuoka, Mainak Das Gupta, Galen J. Tiong, Manizah Huq, Thomas Werner, Et. Al.
Butterfly Eyespots Evolved Via Cooption Of An Ancestral Gene-Regulatory Network That Also Patterns Antennae, Legs, And Wings, Suriya Narayanan Murugesan, Heidi Connahs, Yuji Matsuoka, Mainak Das Gupta, Galen J. Tiong, Manizah Huq, Thomas Werner, Et. Al.
Michigan Tech Publications
Butterfly eyespots are beautiful novel traits with an unknown developmental origin. Here we show that eyespots likely originated via cooption of parts of an ancestral appendage gene-regulatory network (GRN) to novel locations on the wing. Using comparative transcriptome analysis, we show that eyespots cluster most closely with antennae, relative to multiple other tissues. Furthermore, three genes essential for eyespot development, (), (), and (), share similar regulatory connections as those observed in the antennal GRN. CRISPR knockout of -regulatory elements (CREs) for and led to the loss of eyespots, antennae, legs, and also wings, demonstrating that these CREs are highly …
Understanding The Modus Operandi Of Class Ii Knox Transcription Factors In Secondary Cell Wall Biosynthesis, Akula Nookaraju, Shashank K. Pandey, Yogesh Ahlawat, Chandrashekhar P. Joshi
Understanding The Modus Operandi Of Class Ii Knox Transcription Factors In Secondary Cell Wall Biosynthesis, Akula Nookaraju, Shashank K. Pandey, Yogesh Ahlawat, Chandrashekhar P. Joshi
Michigan Tech Publications
Lignocellulosic biomass from the secondary cell walls of plants has a veritable potential to provide some of the most appropriate raw materials for producing second-generation biofuels. Therefore, we must first understand how plants synthesize these complex secondary cell walls that consist of cellulose, hemicellulose, and lignin in order to deconstruct them later on into simple sugars to produce bioethanol via fermentation. Knotted-like homeobox (KNOX) genes encode homeodomain-containing transcription factors (TFs) that modulate various important developmental processes in plants. While Class I KNOX TF genes are mainly expressed in the shoot apical meristems of both monocot and eudicot plants and are …
Impact Of Edds Dosage On Lead Phytoextraction In Contaminated Urban Residential Soils, Zhiming Zhang, Dibyendu Sarkar, Virinder Sidhu, Manas Warke, Rupali Datta
Impact Of Edds Dosage On Lead Phytoextraction In Contaminated Urban Residential Soils, Zhiming Zhang, Dibyendu Sarkar, Virinder Sidhu, Manas Warke, Rupali Datta
Michigan Tech Publications
Lead (Pb) contamination in soils of residential properties due to peeling and chipping of Pb-based paint can cause human health problems. Phytoextraction is a green technology that has the potential to remediate soil Pb. The efficiency of phytoextraction is dependent on the geochemical forms of Pb in soil. A biodegradable chelating agent, ethylenediaminedisuccinic acid (EDDS), was previously shown to enhance Pb removal by facilitating phytoextraction. In this study, EDDS was tested at various concentrations for its potential in mobilizing Pb in urban residential soils in Jersey City, New Jersey, and San Antonio, Texas. Results show that the concentrations of plant-available …
A Cross-Ecoregion Evaluation Of Nitrogen Fixation And Denitrification In Streams And Rivers Of The United States Of America, Amy Marcarelli, Erin K. Eberhard, Michelle Kelly, Kevin Nevorski
A Cross-Ecoregion Evaluation Of Nitrogen Fixation And Denitrification In Streams And Rivers Of The United States Of America, Amy Marcarelli, Erin K. Eberhard, Michelle Kelly, Kevin Nevorski
Michigan Tech Publications
It is typically assumed that dinitrogen (N2) fixation and denitrification are mutually exclusive processes in riverine ecosystems because N2 fixation is favored in high light, low nitrogen (N) environments but denitrification is favored under anoxic, high N conditions. Yet recent work in marine and lake ecosystems has demonstrated that N2 fixation can happen under high N conditions and in sediments, challenging this assumption. We conducted a cross-ecoregion study to test the hypothesis that N2 fixation and denitrification would co-occur in streams and rivers across a range of reactive N concentrations. Between 2017 and 2019, we sampled 30 streams in 13 …
Β-Hydroxy-Β-Methylbutyrate Supplementation Promotes Antitumor Immunity In An Obesity Responsive Mouse Model Of Pancreatic Ductal Adenocarcinoma, Michael F. Coleman, Kristyn A. Liu, Alexander J. Pfeil, Suhas K. Etigunta, Xiaohu Tang, Salvador Fabela, Et. Al.
Β-Hydroxy-Β-Methylbutyrate Supplementation Promotes Antitumor Immunity In An Obesity Responsive Mouse Model Of Pancreatic Ductal Adenocarcinoma, Michael F. Coleman, Kristyn A. Liu, Alexander J. Pfeil, Suhas K. Etigunta, Xiaohu Tang, Salvador Fabela, Et. Al.
Michigan Tech Publications
Pancreatic cancer (PDAC) is a deadly disease, exacerbated by obesity, which lacks effective therapeutic interventions. Most PDAC has a limited response to immune- and chemotherapy. Treating PDAC is made additionally challenging by the rapid emergence of muscle wasting and cachexia, which predict poor response to several therapies. We have found that dietary supplementation with β-hydroxy-β-methylbutyrate promotes immunosurveillance in PDAC tumors and protects muscle. This dietary supplement has the potential to be an important adjuvant in PDAC therapy, opening the doors to immunotherapy response.
Adsorption Of Perfluorooctanoic Acid (Pfoa) And Perfluorooctanesulfonic Acid (Pfos) By Aluminum-Based Drinking Water Treatment Residuals, Zhiming Zhang, Dibyendu Sarkar, Rupali Datta, Yang Deng
Adsorption Of Perfluorooctanoic Acid (Pfoa) And Perfluorooctanesulfonic Acid (Pfos) By Aluminum-Based Drinking Water Treatment Residuals, Zhiming Zhang, Dibyendu Sarkar, Rupali Datta, Yang Deng
Michigan Tech Publications
Per- and polyfluoroalkyl substances (PFAS) represent a family of emerging persistent organic pollutants. Cost-effective remediation of PFAS contamination via chemical or biochemical degradation is challenging due to their extremely high stability. This study reports the removal of two representative PFAS species, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), from water by adsorption using aluminum-based water treatment residuals (Al-WTR), a non-hazardous waste generated during the process of drinking water treatment by alum salts. Rapid adsorption of PFOA and PFOS onto Al-WTR followed a pseudo 2nd order kinetic pattern. Lower pH facilitated the adsorption process with a faster adsorption rate and greater …
Activation Of Orexin System Stimulates Camkii Expression, Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, Zhiying Shan
Activation Of Orexin System Stimulates Camkii Expression, Yuanyuan Fan, Enshe Jiang, Huanjia Gao, Jeremy Bigalke, Bojun Chen, Chunxiu Yu, Qinghui Chen, Zhiying Shan
Michigan Tech Publications
Hyperactivity of the orexin system within the paraventricular nucleus (PVN) has been shown to contribute to increased sympathetic nerve activity (SNA) and blood pressure (BP) in rodent animals. However, the underlying molecular mechanisms remain unclear. Here, we test the hypothesis that orexin system activation stimulates calcium/calmodulin-dependent kinase II (CaMKII) expression and activation, and stimulation of CaMKII expressing PVN neurons increases SNA and BP. Real-time PCR and/or western blot were carried out to test the effect of orexin-A administration on CaMKII expression in the PVN of normal Sprague Dawley (SD) rats and orexin receptor 1 (OX1R) expressing PC12 cells. Immunostaining was …
Nutrient Limitation Of Algae And Macrophytes In Streams: Integrating Laboratory Bioassays, Field Experiments, And Field Data, Christopher A. Mebane, Andrew M. Ray, Amy Marcarelli
Nutrient Limitation Of Algae And Macrophytes In Streams: Integrating Laboratory Bioassays, Field Experiments, And Field Data, Christopher A. Mebane, Andrew M. Ray, Amy Marcarelli
Michigan Tech Publications
Successful eutrophication control strategies need to address the limiting nutrient. We conducted a battery of laboratory and in situ nutrient-limitation tests with waters collected from 9 streams in an agricultural region of the upper Snake River basin, Idaho, USA. Laboratory tests used the green alga Raphidocelis subcapitata, the macrophyte Lemna minor (duckweed) with native epiphytes, and in situ nutrient-limitation tests of periphyton were conducted with nutrient-diffusing substrates (NDS). In the duckweed/epiphyte test, P saturation occurred when concentrations reached about 100 μg/L. Chlorophyll a in epiphytic periphyton was stimulated at low P additions and by about 100 μg/L P, epiphytic periphyton …
Scientific Access Into Mercer Subglacial Lake: Scientific Objectives, Drilling Operations And Initial Observations, John C. Priscu, Jonas Kalin, John Winans, Timothy Campbell, Matthew R. Siegfried, Mark Skidmore, Trista J. Vick‐Majors, Et. Al.
Scientific Access Into Mercer Subglacial Lake: Scientific Objectives, Drilling Operations And Initial Observations, John C. Priscu, Jonas Kalin, John Winans, Timothy Campbell, Matthew R. Siegfried, Mark Skidmore, Trista J. Vick‐Majors, Et. Al.
Michigan Tech Publications
The Subglacial Antarctic Lakes Scientific Access (SALSA) Project accessed Mercer Subglacial Lake using environmentally clean hot-water drilling to examine interactions among ice, water, sediment, rock, microbes and carbon reservoirs within the lake water column and underlying sediments. A ∼0.4 m diameter borehole was melted through 1087 m of ice and maintained over ∼10 days, allowing observation of ice properties and collection of water and sediment with various tools. Over this period, SALSA collected: 60 L of lake water and 10 L of deep borehole water; microbes >0.2 μm in diameter from in situ filtration of ∼100 L of lake water; …