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Full-Text Articles in Life Sciences

Crystallization And Polymerization, Otto Vogl, Frank T. Traceski, Eric G. Vogl Oct 2012

Crystallization And Polymerization, Otto Vogl, Frank T. Traceski, Eric G. Vogl

Otto Vogl

No abstract provided.


Pictures From My Life With Polymer Science: Album 12, Otto Vogl Sep 2012

Pictures From My Life With Polymer Science: Album 12, Otto Vogl

Otto Vogl

No abstract provided.


Solid State Chemical Reactions And Polymerizations: The Initial Synthesis Of Dna?, Otto Vogl, Frank T. Traceski Jun 2012

Solid State Chemical Reactions And Polymerizations: The Initial Synthesis Of Dna?, Otto Vogl, Frank T. Traceski

Otto Vogl

A Proposal for Covering individual Macromolecules with Macromolecules including a Realistic Chiral Synthesis of Nucleic Acids.


Does The Precision Of A Biological Clock Depend Upon Its Period? Effects Of The Duper And Tau Mutations In Syrian Hamsters, Eric L. Bittman May 2012

Does The Precision Of A Biological Clock Depend Upon Its Period? Effects Of The Duper And Tau Mutations In Syrian Hamsters, Eric L. Bittman

Eric L. Bittman

Mutations which alter the feedback loops that generate circadian rhythms may provide insight into their insensitivity to perturbation robustness) and their consistency of period (precision). I examined relationships between endogenous period, activity and rest (τDD, α and ρ) in Syrian hamsters using two different mutations, duper and tau, both of which speed up the circadian clock. I generated 8 strains of hamsters that are homozygous or heterozygous for the tau, duper, and wild type alleles in all combinations. The endogenous period of activity onsets among these strains ranged from 17.94+0.04 to 24.13±0.04 h. Contrary to predictions, the variability of period …


Macondo Crude Oil From The Deepwater Horizon Oil Spill Disrupts Specific Developmental Processes During Zebrafish Embryogenesis, T Yvanka De Soysa, Allison Ulrich, Timo Friedrich, Danielle Pite, Shannon L. Compton, Deborah Ok, Rebecca L. Bernardos, Gerald B. Downes, Shizuka Hsieh, Rachael Stein, M Caterina Lagdameo, Katherine Halvorsen, Lydia-Rose Kesich, Michael Jf Barresi May 2012

Macondo Crude Oil From The Deepwater Horizon Oil Spill Disrupts Specific Developmental Processes During Zebrafish Embryogenesis, T Yvanka De Soysa, Allison Ulrich, Timo Friedrich, Danielle Pite, Shannon L. Compton, Deborah Ok, Rebecca L. Bernardos, Gerald B. Downes, Shizuka Hsieh, Rachael Stein, M Caterina Lagdameo, Katherine Halvorsen, Lydia-Rose Kesich, Michael Jf Barresi

Gerald B. Downes

Background: The Deepwater Horizon disaster was the largest marine oil spill in history, and total vertical exposure of oil to the water column suggests it could impact an enormous diversity of ecosystems. The most vulnerable organisms are those encountering these pollutants during their early life stages. Water-soluble components of crude oil and specific polycyclic aromatic hydrocarbons have been shown to cause defects in cardiovascular and craniofacial development in a variety of teleost species, but the developmental origins of these defects have yet to be determined. We have adopted zebrafish, Danio rerio, as a model to test whether water accumulated fractions …


Identification And Expression Analysis Of Methyl Jasmonate Responsive Ests In Paclitaxel Producing Taxus Cuspidata Suspension Culture Cells, Sangram K. Lenka, Nadia Boutaoui, Bibin Paulose, Kham Vongpaseuth, Jennifer Normanly, Susan C. Roberts, Elsbeth L. Walker Apr 2012

Identification And Expression Analysis Of Methyl Jasmonate Responsive Ests In Paclitaxel Producing Taxus Cuspidata Suspension Culture Cells, Sangram K. Lenka, Nadia Boutaoui, Bibin Paulose, Kham Vongpaseuth, Jennifer Normanly, Susan C. Roberts, Elsbeth L. Walker

Elsbeth Walker

Background Taxol(R)(paclitaxel) promotes microtubule assembly and stabilization and therefore is a potent chemotherapeutic agent against wide range of cancers. Methyl jasmonate (MJ) elicited Taxus cell cultures provide a sustainable option to meet the growing market demand for paclitaxel. Despite its increasing pharmaceutical importance, the molecular genetics of paclitaxel biosynthesis is not fully elucidated. This study focuses on identification of MJ responsive transcripts in cultured Taxus cells using PCR-based suppression subtractive hybridization (SSH) to identify genes involved in global pathway control. Results Six separate SSH cDNA libraries of paclitaxel-accumulating Taxus cuspidata P991 cell lines were constructed at three different post-elicitation time …


Transcriptional Regulation Of Grass Secondary Cell Wall Biosynthesis: Playing Catch-Up With Arabidopsis Thaliana, Pubudu P. Handakumbura, Samuel P. Hazen Apr 2012

Transcriptional Regulation Of Grass Secondary Cell Wall Biosynthesis: Playing Catch-Up With Arabidopsis Thaliana, Pubudu P. Handakumbura, Samuel P. Hazen

Samuel P Hazen

Secondary cell wall synthesis occurs in specialized cell types following completion of cell enlargement. By virtue of mechanical strength provided by a wall thickened with cellulose, hemicelluloses, and lignin, these cells can function as water-conducting vessels and provide structural support. Several transcription factor families regulate genes encoding wall synthesis enzymes. Certain NAC and MYB proteins directly bind to the SNBE and AC elements upstream of structural genes and other transcription factors. The most detailed model of this regulatory network is established predominantly for a eudicot, Arabidopsis thaliana. In grasses, both the patterning and the composition of secondary cell walls are …


Mutation Of Zebrafish Dihydrolipoamide Branched-Chain Transacylase E2 Results In Motor Dysfunction And Models Maple Syrup Urine Disease, Timo Friedrich, Aaron M. Lambert, Mark A. Masino, Gerald B. Downes Mar 2012

Mutation Of Zebrafish Dihydrolipoamide Branched-Chain Transacylase E2 Results In Motor Dysfunction And Models Maple Syrup Urine Disease, Timo Friedrich, Aaron M. Lambert, Mark A. Masino, Gerald B. Downes

Gerald B. Downes

Analysis of zebrafish mutants that demonstrate abnormal locomotive behavior can elucidate the molecular requirements for neural network function and provide new models of human disease. Here, we show that zebrafish quetschkommode (que) mutant larvae exhibit a progressive locomotor defect that culminates in unusual nose-to-tail compressions and an inability to swim. Correspondingly, extracellular peripheral nerve recordings show that que mutants demonstrate abnormal locomotor output to the axial muscles used for swimming. Using positional cloning and candidate gene analysis, we reveal that a point mutation disrupts the gene encoding dihydrolipoamide branched-chain transacylase E2 (Dbt), a component of a mitochondrial enzyme complex, to …


Biological Conversion Assay Using Clostridium Phytofermentans To Estimate Plant Feedstock Quality, Scott J. Lee, Thomas A. Warnick, Sivakumar Pattahil, Jesus G. Alvelo-Maurosa, Michelle J. Serapiglia, Heather Mccormick, Virginia Brown, Naomi F. Young, Danny J. Schnell, Lawrence B. Smart, Michael G. Hahn, Jeffrey F. Pedersen, Susan B. Leschine, Samuel P. Hazen Feb 2012

Biological Conversion Assay Using Clostridium Phytofermentans To Estimate Plant Feedstock Quality, Scott J. Lee, Thomas A. Warnick, Sivakumar Pattahil, Jesus G. Alvelo-Maurosa, Michelle J. Serapiglia, Heather Mccormick, Virginia Brown, Naomi F. Young, Danny J. Schnell, Lawrence B. Smart, Michael G. Hahn, Jeffrey F. Pedersen, Susan B. Leschine, Samuel P. Hazen

Samuel P Hazen

Background - There is currently considerable interest in developing renewable sources of energy. One strategy is the biological conversion of plant biomass to liquid transportation fuel. Several technical hurdles impinge upon the economic feasibility of this strategy, including the development of energy crops amenable to facile deconstruction. Reliable assays to characterize feedstock quality are needed to measure the effects of pre-treatment and processing and of the plant and microbial genetic diversity that influence bioconversion efficiency. Results - We used the anaerobic bacterium Clostridium phytofermentans to develop a robust assay for biomass digestibility and conversion to biofuels. The assay utilizes the …


Pictures From My Life With Polymer Science: Album 11, Otto Vogl Feb 2012

Pictures From My Life With Polymer Science: Album 11, Otto Vogl

Otto Vogl

No abstract provided.


Chirality And Handedness, Otto Vogl, Frank T. Traceski Jan 2012

Chirality And Handedness, Otto Vogl, Frank T. Traceski

Otto Vogl

No abstract provided.


How Pearls Are Made: A New Perspective, Otto Vogl Jan 2012

How Pearls Are Made: A New Perspective, Otto Vogl

Otto Vogl

No abstract provided.


Degradadation, Aging And Stabilization, Otto Vogl Jan 2012

Degradadation, Aging And Stabilization, Otto Vogl

Otto Vogl

No abstract provided.


From The Congress In Vienna (Metternich) To The Pacific Polymer Federation, Otto Vogl, Frank T. Traceski Jan 2012

From The Congress In Vienna (Metternich) To The Pacific Polymer Federation, Otto Vogl, Frank T. Traceski

Otto Vogl

No abstract provided.