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Articles 1951 - 1980 of 35861
Full-Text Articles in Life Sciences
Effect Of Carnosol On G Protein-Coupled Receptor Signaling In Cancer Cells, Laith Jehad Ahmad Abudawood
Effect Of Carnosol On G Protein-Coupled Receptor Signaling In Cancer Cells, Laith Jehad Ahmad Abudawood
Theses
Carnosol is a plant polyphenol compound known for its beneficial properties against human diseases such as cancer and diabetes. However, the exact molecular and cellular mechanisms involved, and its molecular targets are not fully known. Carnosol was shown to bind and to modulate specific intracellular signaling proteins in cancer cell lines. In this study, we hypothesized that carnosol may pharmacologically target specific cell surface receptors including G Protein-Coupled Receptors (GPCRs) and Receptor Tyrosine Kinase (RTKs). Therefore, we tested the pharmacological effect of carnosol on the following receptors: Insulin Receptor (IR), Chemokine CXCL12 Receptor (CXCR4), Angiotensin II (AngII) Receptor (AT1R), Glucagon-Like …
Screening For Endophytic Actinobacteria To Enhance Growth And Salinity Tolerance Of Tomato Plants In The United Arab, Amira Hamdy Hassan
Screening For Endophytic Actinobacteria To Enhance Growth And Salinity Tolerance Of Tomato Plants In The United Arab, Amira Hamdy Hassan
Theses
Salinity is one of the most decisive environmental factors limiting the productivity of crop plants, mainly in arid and semi-arid regions. An eco-friendly technology can be used to boost crop production in saline areas by using plant growth-bacteria. Endophytic actinobacteria that produce the enzyme 1-Aminocyclopropane-1-Carboxylic acid (ACC) Deaminase (ACCD) can modulate the levels of Ethylene (ET) in plants to reduce the effect of abiotic stresses including high salt stress. The main objectives of this study were to: (1) Evaluate endophytic actinobacterial isolates from healthy tomato plants cultivated in the UAE that are capable of producing ACCD in vitro; (2) …
Maternal Effects On Growth Parameters Of Chloris Gayana Under Co2 Enrichment, Ahmed Adnan Mohammed Mashli
Maternal Effects On Growth Parameters Of Chloris Gayana Under Co2 Enrichment, Ahmed Adnan Mohammed Mashli
Theses
Rhodes grass, Chloris gayana, is commonly used forage plant for grazers, livestock, and cattle. It significantly improves soil fertility and its overall structure by preventing nematode flourishment in soil. It is also used as a cover crop to upgrade soil health by reducing soil erosion and increasing water availability. The present study assessed the effects of CO2 on the growth, development and maternal effects of C. gayana. The experimental setup was made in such a way that the potential impacts of CO2 can be measured on the eco-physiological growth of C. gayana by studying successive generations. Generation 1 …
Comparison Of Protein Extraction Protocols And Allergen Mapping From Black Soldier Fly Hermetia Illucens, Utpal Bose, James A. Broadbent, Angéla Juhász, Shaymaviswanathan Karnaneedi, Elecia B. Johnston, Sally Stockwell, Keren Byrne, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Andreas L. Lopata, Michelle L. Colgrave
Comparison Of Protein Extraction Protocols And Allergen Mapping From Black Soldier Fly Hermetia Illucens, Utpal Bose, James A. Broadbent, Angéla Juhász, Shaymaviswanathan Karnaneedi, Elecia B. Johnston, Sally Stockwell, Keren Byrne, Vachiranee Limviphuvadh, Sebastian Maurer-Stroh, Andreas L. Lopata, Michelle L. Colgrave
Research outputs 2022 to 2026
Exploration of important insect proteins — including allergens — and proteomes can be limited by protein extraction buffer selection and the complexity of the proteome. Herein, LC-MS/MS-based proteomics experiments were used to assess the protein extraction efficiencies for a suite of extraction buffers and the effect of ingredient processing on proteome and allergen detection. Discovery proteomics revealed that SDS-based buffer yields the maximum number of protein groups from three types of BSF samples. Bioinformatic analysis revealed that buffer composition and ingredient processing could influence allergen detection. Upon applying multi-level filtering criteria, 33 putative allergens were detected by comparing the detected …
Administration Of Broadly Neutralizing Anti-Hiv-1 Antibodies At Art Initiation Maintains Long-Term Cd8+ T Cell Immunity, Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane H. Schleimann, Paul W. Denton, Victor Ramos, Adam R. Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard
Administration Of Broadly Neutralizing Anti-Hiv-1 Antibodies At Art Initiation Maintains Long-Term Cd8+ T Cell Immunity, Miriam Rosás-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane H. Schleimann, Paul W. Denton, Victor Ramos, Adam R. Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escribà, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Søgaard
Biology Faculty Publications
In simian-human immunodeficiency virus (SHIV)-infected non-human primates, broadly neutralizing antibodies (bNAbs) against the virus appear to stimulate T cell immunity. To determine whether this phenomenon also occurs in humans we measured HIV-1-specific cellular immunity longitudinally in individuals with HIV-1 starting antiviral therapy (ART) with or without adjunctive bNAb 3BNC117 treatment. Using the activation-induced marker (AIM) assay and interferon-γ release, we observe that frequencies of Pol- and Gag-specific CD8+ T cells, as well as Gag-induced interferon-γ responses, are significantly higher among individuals that received adjunctive 3BNC117 compared to ART-alone at 3 and 12 months after starting ART. The observed changes in …
Comparison Of The Humoral Immune Response Following Both Bacterial Challenge And Rnai Of Major Factors On Proliferation Of Bartonella Quintana In The Human Louse, Jake Zina
Masters Theses
Human body lice, Pediculus humanus humanus, and head lice, Pediculus humanus capitis, have been hematophagous ectoparasites of humans for thousands of years. Despite being ecotypes, only body lice are known to transmit bacterial diseases to humans, and it appears that lower humoral and cellular immune responses allow body lice to possess a higher vector competence. We previously observed that the transcription level of the defensin 1 gene was up-regulated only in head lice following oral challenge of Bartonella quintana, a causative agent of trench fever, and also that body lice excreted more viable B. quintana in their …
Changes In Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping To Fac-Sorted Bacteria, Christopher A. Colvin
Changes In Gene Expression From Long-Term Warming Revealed Using Metatranscriptome Mapping To Fac-Sorted Bacteria, Christopher A. Colvin
Masters Theses
Soil microbiomes play pivotal roles to the health of the environment by maintaining metabolic cycles. One question is how will climate change affect soil bacteria over time and what could the repercussions be. To answer these questions, the Harvard Forest Long-Term Warming Experiment was established to mimic predicted climate change by warming plots of land 5℃ above ambient conditions. In 2017, 14 soil core samples were collected from Barre Woods warming experiment to mark 15 years since the establishment of the soil warming in that location. These samples underwent traditional metatranscriptomics to generate an mRNA library as well as a …
Chemosensory Receptors In Berghia Stephanieae: Bioinformatics And Localization, Kelsi L. Watkins
Chemosensory Receptors In Berghia Stephanieae: Bioinformatics And Localization, Kelsi L. Watkins
Masters Theses
Chemosensation is achieved through the binding of chemical signals to chemoreceptor proteins embedded in the membranes of sensory neurons. The molecular identity of these receptors, as well as the downstream processing of chemosensory signals, has been well studied in arthropods and vertebrates. However, very little is known about molluscan chemosensation. The identity of chemoreceptor proteins in the nudibranch mollusc Berghia stephanieae are unknown. Data from other protostome and molluscan studies suggest Berghia may use ionotropic receptors for some forms of chemoreception. This study used a bioinformatics approach to identify potential chemosensory ionotropic receptors in the transcriptome of Berghia. A …
Root-Inhabiting And Rhizosphere Mycobiomes And Crop Yield Of Corn And Wheat, Marianna E. Wallace
Root-Inhabiting And Rhizosphere Mycobiomes And Crop Yield Of Corn And Wheat, Marianna E. Wallace
Electronic Thesis and Dissertation Repository
The root mycobiome plays a direct role in plant productivity, and the study of its community composition allows for identification of organisms that influence plant health. To better understand the role of fungal community composition in crop productivity, the root-associated mycobiomes of historically high and low yield sites of corn and wheat planted in rotation were characterized and analyzed along with soil physicochemical variables and crop yield. In each field studied, root and rhizosphere mycobiomes reflected significant differences in fungal species composition. Several soil variables were found to be predictors of differences in composition of sample types including soil texture …
Utilizing Maternal Investment Strategies Of Sharks To Develop Management Tools To Aid In Shark Conservation, Dennis Deeken
Utilizing Maternal Investment Strategies Of Sharks To Develop Management Tools To Aid In Shark Conservation, Dennis Deeken
USF Tampa Graduate Theses and Dissertations
Every generation, breeding females and males repopulate ecosystems with the next generation of offspring. Two models link maternal investments in offspring size and number to natural selection processes. In unstable resource environments, bet-hedging models predict a conservative tradeoff in maternal investments resulting in moderate egg size and clutch size within a given range of sizes for a given species. r/K selection models make predictions on maternal investments across species. In unstable resource environments, r-selected species invest in large broods of small offspring. In stable environments, K-selected species invest in small broods of large offspring. The maternal risk management model predicts …
Ca2+ Entry Units In A Superfast Fish Muscle, James Matthew Kittelberger, Clara Franzini-Armstrong, Simona Boncompagni
Ca2+ Entry Units In A Superfast Fish Muscle, James Matthew Kittelberger, Clara Franzini-Armstrong, Simona Boncompagni
Biology Faculty Publications
Over the past two decades, mounting evidence has demonstrated that a mechanism known as store-operated Ca2+ entry (SOCE) plays a crucial role in sustaining skeletal muscle contractility by facilitating Ca2+ influx from the extracellular space during sarcoplasmic reticulum (SR) Ca2+ depletion. We recently demonstrated that, in exercised fast-twitch muscle from mice, the incidence of Ca2+ entry units (CEUs), newly described intracellular junctions between dead-end longitudinal transverse tubular (T-tubule) extensions and stacks of sarcoplasmic reticulum (SR) flat cisternae, strictly correlate with both the capability of fibers to maintain contractions during fatigue and enhanced Ca2+ influx via SOCE. Here, we tested the …
Plant Responses To Drought In A Semiarid Grassland: An Isotopic Approach, Elizabeth V. Fain
Plant Responses To Drought In A Semiarid Grassland: An Isotopic Approach, Elizabeth V. Fain
Biology ETDs
Dryland ecosystems are facing unprecedented climate extremes as a result of global climate change. Water is the most limiting factor in dryland ecosystems, therefore plants in drylands have developed crucial water-use strategies for drought survival. It is important to understand plant physiological responses to water stress as drylands are projected to experience more frequent, severe droughts in the coming decades. To test how plants respond to drought in a semiarid grassland, we measured δ13C, δ15N, and C/N ratio of common C3 and C4 plants (Bouteloua gracilis, B. eriopoda, Pleuraphis jamesii, Salsola tragus, Machaeranthera pinnatifida, …
Trick To The Treat Of Internships And Research: Health Literacy Project: Awareness Of Autism In Black And Brown Communities, Varun Kota, Mark Jaffe
Trick To The Treat Of Internships And Research: Health Literacy Project: Awareness Of Autism In Black And Brown Communities, Varun Kota, Mark Jaffe
Trick to the Treat of Internships and Research
No abstract provided.
The Effect Of Spirulina Major And Oscillatoria On Reducing The Acidity Of Freshwater Containing Antibacterial Liquid And Bar Soaps ., Kartik Valluri
The Effect Of Spirulina Major And Oscillatoria On Reducing The Acidity Of Freshwater Containing Antibacterial Liquid And Bar Soaps ., Kartik Valluri
Journal of the South Carolina Academy of Science
No abstract provided.
The Effects Of Rice Bran Oil As A Repellent For Aedes Aegypti Compared To Mineral Oil And Effective Natural Repellents, Aleena Chattha
The Effects Of Rice Bran Oil As A Repellent For Aedes Aegypti Compared To Mineral Oil And Effective Natural Repellents, Aleena Chattha
Journal of the South Carolina Academy of Science
No abstract provided.
The Phytoremediation Of Escherichia Coli In Contaminated Water By Lemna Minor, Salvinia Minima, And Azolla Caroliniana, Madison Han
Journal of the South Carolina Academy of Science
No abstract provided.
The Effectiveness Of Lithium Chloride In Eliciting A Taste Aversion Response In Blaptica Dubia, Ava Phelps
The Effectiveness Of Lithium Chloride In Eliciting A Taste Aversion Response In Blaptica Dubia, Ava Phelps
Journal of the South Carolina Academy of Science
No abstract provided.
Interactions Between Juvenile Estuary-Dependent Fishes And Microalgal Dynamics, Ian C. Williams
Interactions Between Juvenile Estuary-Dependent Fishes And Microalgal Dynamics, Ian C. Williams
USF Tampa Graduate Theses and Dissertations
The ontogenetic movement of juvenile estuary-dependent fishes upstream in estuarine settings is a phenomenon observed around the world. These movements usually coincide with a shift in diet from smaller prey, such as calanoid copepods, to larger prey, such as mysids. However, the mechanism that drives this pattern has yet to be conclusively described. Prior to the current study, zooplankton/hyperbenthos (“zooplankton”), primary production, and water quality data were collected from the Caloosahatchee River estuary in two concurrent and coordinated studies over a two-year period. One of the products of these sampling efforts was a classification of primary-producer types at the sediment-water …
Global Research In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Harsh Chheda, Jeet Patel, Santanu De
Global Research In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Harsh Chheda, Jeet Patel, Santanu De
Trick to the Treat of Internships and Research
The ongoing Coronavirus Infectious Disease 2019 (COVID-19) pandemic has caused a significant disruption in several areas of research within the fields of Anatomy and Physiology. With the whole world coming to a standstill, research of any kind was difficult to pursue, especially in these disciplines requiring kinesthetic/tactile application of concepts or testing hypotheses through hands-on engagement, as the new social guidelines and risks to certain groups of people hindered up-to-date research-data collection. However, with new technology and protocols created or adopted, there has been an effort to better help students and scientists to conduct research remotely; such alternatives cannot effectively …
Global Education In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Sean Mahajan, Sneh Patel, Santanu De
Global Education In Anatomy And Physiology During Covid-19: Lessons Learnt And Future Recommendations, Sean Mahajan, Sneh Patel, Santanu De
Trick to the Treat of Internships and Research
The Coronavirus Infectious Disease 2019 (COVID-19) pandemic has disrupted several essential aspects of anatomy and physiology education worldwide. With this pandemic, dynamic instructional and technological interventions have been taking place rapidly in an effort to minimize the adverse repercussions of moving away from the traditional means of education in these critical scientific disciplines. COVID-19 has necessitated higher educational administrations, faculty, and students to pursue teaching, learning, and assessment of anatomy and physiology courses/curricula through innovative strategies without compromising on the quality or rigor of education. Our study encapsulates, for the first time, globally published reports on the key implications of …
Stem-Away: Mentor Chains Internships, Isha K. Pasumarthi
Stem-Away: Mentor Chains Internships, Isha K. Pasumarthi
Trick to the Treat of Internships and Research
No abstract provided.
Covid-19-Impacted Research And Education In Global Healthcare And Stem: Evaluation Of Case Studies, Yumna Indorewala, Santanu De
Covid-19-Impacted Research And Education In Global Healthcare And Stem: Evaluation Of Case Studies, Yumna Indorewala, Santanu De
Trick to the Treat of Internships and Research
The zoonotic novel coronavirus has posed major challenges to the world’s economy, social development, and public health. Effects in the education and research in the field of healthcare and STEM are accentuated in lower-developed countries or communities where the access to technology and a reliable internet connection are luxuries making it difficult to attain education virtually. The Coronavirus Infectious Disease 2019 (COVID-19) has also disrupted research and training in STEM and healthcare. With significant increases in infection rates there is an urge to redirect projects towards virology research and vaccine development. This comprehensive literature review includes case studies highlighting the …
Flexible Phenotypes, Energetics, And Whole-Animal Performance Of Migratory Songbirds, Michael Griego
Flexible Phenotypes, Energetics, And Whole-Animal Performance Of Migratory Songbirds, Michael Griego
Doctoral Dissertations
Animal life has evolved innumerable strategies to adapt to a great range of environmental conditions present on earth. The physiology of free-living animals has thus been shaped to allow for maximal performance under challenging conditions and has given rise to traits that enable animals to overcome daunting ecological pressures. Few life history stages in the animal kingdom rival the intensity of annual avian migration: the extreme metabolic requirements of long-distance flight coupled with navigating vast and hostile ecological barriers results in enormously high mortality for young birds. It is therefore the main focus of this thesis to identify physiological traits …
Constraints Of The Imagination: How Phenotypes Are Shaped Through Genetics, The Environment, And Development, Michelle Gilbert
Constraints Of The Imagination: How Phenotypes Are Shaped Through Genetics, The Environment, And Development, Michelle Gilbert
Doctoral Dissertations
Phenotypic constraints are ubiquitous throughout nature, being found throughout all stages of life and at multiple different biological levels including cellular, genetic, environmental, behavioral, evolutionary, and developmental. These constraints have shaped, not only the natural world, but the way that we perceive what is possible, or impossible, an observation made clear by François Jacob in his 1977 paper “Evolution and Tinkering”. This is reflected in the literature, repeatedly, by the regular occurrence of densely packed visualization of phenotypic space that seemingly always have large areas that go unoccupied. Despite constrained regions of space being observable across countless taxa, identifying the …
Viruses In Astrobiology, Ignacio De La Higuera, Ester Lázaro
Viruses In Astrobiology, Ignacio De La Higuera, Ester Lázaro
Biology Faculty Publications and Presentations
Viruses are the most abundant biological entities on Earth, and yet, they have not received enough consideration in astrobiology. Viruses are also extraordinarily diverse, which is evident in the types of relationships they establish with their host, their strategies to store and replicate their genetic information and the enormous diversity of genes they contain. A viral population, especially if it corresponds to a virus with an RNA genome, can contain an array of sequence variants that greatly exceeds what is present in most cell populations. The fact that viruses always need cellular resources to multiply means that they establish very …
Correlation Of Phosphorus Adsorption With Chemical Properties Of Aluminum-Based Drinking Water Treatment Residuals Collected From Various Parts Of The United States, Roxana Rahmati, Virinder Sidhu, Rosita Nunez, Rupali Datta, Dibyendu Sarkar
Correlation Of Phosphorus Adsorption With Chemical Properties Of Aluminum-Based Drinking Water Treatment Residuals Collected From Various Parts Of The United States, Roxana Rahmati, Virinder Sidhu, Rosita Nunez, Rupali Datta, Dibyendu Sarkar
Michigan Tech Publications
Over the past several decades, the value of drinking water treatment residuals (WTRs), a byproduct of the coagulation process during water purification, has been recognized in various environmental applications, including sustainable remediation of phosphorus (P)-enriched soils. Aluminum-based WTRs (Al-WTRs) are suitable adsorbent materials for P, which can be obtained and processed inexpensively. However, given their heterogeneous nature, it is essential to identify an easily analyzable chemical property that can predict the capability of Al-WTRs to bind P before soil amendment. To address this issue, thirteen Al-WTRs were collected from various geographical locations around the United States. The non-hazardous nature of …
Subtype C Hiv-1 Reservoirs Throughout The Body In Art-Suppressed Individuals, Zhou Liu, Peter Julius, Guobin Kang, John T. West, Charles Wood
Subtype C Hiv-1 Reservoirs Throughout The Body In Art-Suppressed Individuals, Zhou Liu, Peter Julius, Guobin Kang, John T. West, Charles Wood
School of Biological Sciences: Faculty Publications
Subtype B HIV-1 reservoirs have been intensively investigated, but reservoirs in other subtypes and how they respond to antiretroviral therapy (ART) is substantially less established. To characterize subtype C HIV-1 reservoirs, we implemented postmortem frozen, as well as formalin fixed paraffin embedded (FFPE) tissue sampling of central nervous system (CNS) and peripheral tissues. HIV-1 LTR, gag, envelope (env) DNA and RNA was quantified using genomic DNA and RNA extracted from frozen tissues. RNAscope was used to localize subtype C HIV-1 DNA and RNA in FFPE tissue. Despite uniform viral load suppression in our cohort, PCR results …
Phosphorus And Heavy Metals Removal From Stormwater Runoff Using Granulated Industrial Waste For Retrofitting Catch Basins, Viravid Na Nagara, Dibyendu Sarkar, Rupali Datta
Phosphorus And Heavy Metals Removal From Stormwater Runoff Using Granulated Industrial Waste For Retrofitting Catch Basins, Viravid Na Nagara, Dibyendu Sarkar, Rupali Datta
Michigan Tech Publications
Phosphorus and heavy metals are washed off and transported with stormwater runoff to nearby surface water bodies resulting in environmental and human health risks. Catch basins remain one of the primary gateways through which stormwater runoff and pollutants from urban areas are transported. Retrofitting catch basins to enhance their phosphorus and heavy metal removal can be an effective approach. In this study, aluminum-based water treatment residual (WTR, a non-hazardous byproduct of the water treatment process) was granulated via a green method to serve as a sustainable filter material, called WTR granules, for enhancing the capabilities of catch basins to remove …
Inhibiting Glutamine Utilization Creates A Synthetic Lethality For Suppression Of Atp Citrate Lyase In Kras-Driven Cancer Cells, Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A. Frias, David A. Foster
Inhibiting Glutamine Utilization Creates A Synthetic Lethality For Suppression Of Atp Citrate Lyase In Kras-Driven Cancer Cells, Ahmet Hatipoglu, Deepak Menon, Talia Levy, Maria A. Frias, David A. Foster
Publications and Research
Metabolic reprogramming is now considered a hallmark of cancer cells. KRas-driven cancer cells use glutaminolysis to generate the tricarboxylic acid cycle intermediate α -ketoglutarate via a transamination reaction between glutamate and oxaloacetate. We reported previously that exogenously supplied unsaturated fatty acids could be used to synthesize phosphatidic acid–a lipid second messenger that activates both mammalian target of rapamycin (mTOR) complex 1 (mTORC1) and mTOR complex 2 (mTORC2). A key target of mTORC2 is Akt–a kinase that promotes survival and regulates cell metabolism. We report here that mono- unsaturated oleic acid stimulates the phosphoryla tion of ATP citrate lyase (ACLY) at …
Enriched Dietary Saturated Fatty Acids Induce Trained Immunity Via Ceramide Production That Enhances Severity Of Endotoxemia And Clearance Of Infection, Amy L. Seufert, James W. Hickman, Ste K. Traxler, Rachael M. Peterson, Trent A. Waugh, Sydney L. Lashley, Natalia Shulzhenko, Ruth J. Napier, Brooke A. Napier
Enriched Dietary Saturated Fatty Acids Induce Trained Immunity Via Ceramide Production That Enhances Severity Of Endotoxemia And Clearance Of Infection, Amy L. Seufert, James W. Hickman, Ste K. Traxler, Rachael M. Peterson, Trent A. Waugh, Sydney L. Lashley, Natalia Shulzhenko, Ruth J. Napier, Brooke A. Napier
Biology Faculty Publications and Presentations
Trained immunity is an innate immune memory response that is induced by a primary inflammatory stimulus that sensitizes monocytes and macrophages to a secondary pathogenic challenge, reprogramming the host response to infection and inflammatory disease. Dietary fatty acids can act as inflammatory stimuli, but it is unknown if they can act as the primary stimuli to induce trained immunity. Here we find mice fed a diet enriched exclusively in saturated fatty acids (ketogenic diet; KD) confer a hyper-inflammatory response to systemic lipopolysaccharide (LPS) and increased mortality, independent of diet-induced microbiome and hyperglycemia. We find KD alters the composition of the …