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P53 Maintains Hepatic Cell Identity During Liver Regeneration, Zeynep Hande Coban Akdemir
P53 Maintains Hepatic Cell Identity During Liver Regeneration, Zeynep Hande Coban Akdemir
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p53 MAINTAINS HEPATIC CELL IDENTITY DURING LIVER REGENERATION
Zeynep Hande Coban Akdemir, B.S.,M.A.
Advisory Professor: Michelle Craig Barton, Ph.D.
p53 is a tumor suppressor that has been well studied in tumor-derived, cultured cells. However, its functions in normal proliferating cells and tissues are generally overlooked. We propose that p53 functions during the G1-S transition can be studied in normal, differentiated cells during surgery-induced liver regeneration. Two-thirds partial hepatectomy (PH) of mouse liver offers a unique model to compare p53 functions in regenerating versus sham (control) cells. My hypothesis is that intersection of global expression analyses (microarray and RNA sequencing) and …