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Full-Text Articles in Life Sciences
Detection Of Genomic Inversion From Single End Read, Pankaj Ghimire
Detection Of Genomic Inversion From Single End Read, Pankaj Ghimire
Master's Theses
Structural Variations (SVs) are genomic rearrangements that include both copy-number variants,such as insertion,deletions, duplications and balanced variants like inversion and translocations. These SVs are getting more attentions for research and investigation because of their role on human phenotype, genetic diseases and genomic rearrangements. Evolution of Next-generation Sequencing has provided golden opportunities to investigate these variants and make their wider and clear spectrum in human genome. This investigation includes identification of type of SVs and their breakpoints at base pair level. For their effective identification and breakpoint resolution, many techniques are devised mainly based on paired end read. With relatively low …
Evolution Of Interactomes, Monica Micek
Evolution Of Interactomes, Monica Micek
Master's Theses
Protein-protein interactions are part of all biological processes and are responsible for directing the development and maintenance of all systems in a species. Identifying such interactions provides insight into molecular processes in addition to their importance in understanding disease. Identifying protein-protein interactions experimentally is expensive, both in terms of cost and effort, and can generate erroneous results. Thus computational methods are key in reducing the scope of experimental assays, providing predictions for subsequent verification. Herein I present a new computational tool for the prediction of protein-protein interactions which, looking at sequence data alone, can identify putative interacting proteins as a …