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Full-Text Articles in Life Sciences
Intrinsically Disordered Proteins And Their Role In Biomolecular Condensates, Danielle Latham
Intrinsically Disordered Proteins And Their Role In Biomolecular Condensates, Danielle Latham
All Dissertations
Proteins are biomacromolecules responsible for the functions of life. While classically proteins are thought to be well structured in order to perform a specific function, 50% of proteins within Eukaryotic cells contain intrinsically disordered regions (IDRs), regions with no well-defined structure. IDRs are often used for cell signaling, responding to external factors such as temperature changes or the presence of small molecules. To understand how IDRs can function without structure, it is important to understand the dynamics of such systems. Understanding IDR intramolecular and intermolecular interactions will shed light on IDR dynamics. Intramolecular interactions are first explored using fluorescence spectroscopy …
Synthesis And Biophysical Analysis Of Modified Cell-Penetrating Peptides, Joel Mitchell
Synthesis And Biophysical Analysis Of Modified Cell-Penetrating Peptides, Joel Mitchell
Theses and Dissertations (Comprehensive)
Cell-penetrating peptides (CPPs) are a family of peptides that have the ability to penetrate biological membranes. They were discovered in the late 1980s and have been the topic of many studies. Much of the interest in CPPs has been due to their ability to translocate biological membranes, and the possibility that they could offer a novel drug delivery method by conjugation to biologically active molecules. Linear CPPs can be modified to form cyclic structures. This change in structure has been observed to enhance the stability and penetrative ability of the CPPs which have been studied. The current thesis focuses on …