Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Computational Chemistry (2)
- AZD-4320 (1)
- Asphalt emission (1)
- BCL-2 (1)
- BH3 Mimetics (1)
-
- Biophysical studies (1)
- Chemical and life science engineering (1)
- Drug Discovery (1)
- Glioblastoma (1)
- Glioma (1)
- Head and Neck Cancer (1)
- IRF-1 (1)
- Lung Cancer (1)
- Molecular modeling (1)
- Other (1)
- Protein Structure (1)
- Protein-Protein Interactions (1)
- Senescence (1)
- Spontaneous Glioma (1)
- Tumor Microenvironment. Brain Tumor (1)
- Vitamin B6 (1)
- Publication
- Publication Type
Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Inferring Dynamics Of Biological Systems, Tracey G. Oellerich
Inferring Dynamics Of Biological Systems, Tracey G. Oellerich
Biology and Medicine Through Mathematics Conference
No abstract provided.
Structure-Based Drug Discovery And Development Of Protein Structure Prediction Tools Using An Empirical Force Field, Noah B. Herrington
Structure-Based Drug Discovery And Development Of Protein Structure Prediction Tools Using An Empirical Force Field, Noah B. Herrington
Theses and Dissertations
Traditional drug discovery has rapidly accelerated thanks to development of computational molecular modeling. The crucial component that these computational studies hinge upon is having a well-defined, and energetically favorable structure. Structures of proteins and ligands that meet these criteria are important for accurately simulating models used to study drug binding. To demonstrate the role of accurate structure simulation in the study of these events, this thesis presents, first, a story examining the problem of accurate structure modeling of ionizable residues within protein structures, specifically aspartic acid, glutamic acid, and histidine. I present our method, which uses the HINT force field …
Review Of The Effects Of Asphalt Fume Emission (Vocs And Pahs) In Vitro, In Vivo And Human Studies, Omran Taqi, Nastassja Lewinski, Elham Fini, Eran Rozewski, Judith Klein-Seetharaman
Review Of The Effects Of Asphalt Fume Emission (Vocs And Pahs) In Vitro, In Vivo And Human Studies, Omran Taqi, Nastassja Lewinski, Elham Fini, Eran Rozewski, Judith Klein-Seetharaman
Undergraduate Research Posters
Review of the effects of Asphalt fume emission (VOCs and PAHs) in vitro, in vivo and human studies
Omran Taqi, Nastassja Lewinski1
1) Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA
Background
Asphalt is abundantly available around human operations including road paving and roofing sites. However, their emissions and fumes (specifically volatile organic compounds (VOCs) and polycyclic aromatic hydrocarbons (PAHs)) have been found to have adverse effects on health. Asphalt fumes are a class 2A carcinogen and exposure can increase the risk of lung cancer, asthma, headache, fatigue, and other cardiovascular diseases.
Methods
We used …
The Role Of Irf-1 In Spontaneous Mouse Glioma, Aakash B. Vaidya
The Role Of Irf-1 In Spontaneous Mouse Glioma, Aakash B. Vaidya
Theses and Dissertations
Glioblastoma Multiforme has been shown to be one of the deadliest primary brain cancers. One of the reasons why GBM is so deadly, is a unique immunosuppressive tumor microenvironment that promotes GBM growth and progression. Both astrocyte and microglia have been implicated in immunosuppression. In this study, we explored the role of Interferon Regulatory Factor 1 (IRF-1) in astrocytes and glioma cells on the growth of spontaneous glioma tumors. IRF-1 is regulated by the JAK/STAT pathway and induces expression of Programmed death ligand 1 (PD-L1). PD-L1 downregulates immune responses to glioma. We found that IRF-1 had no effect on spontaneous …
Protein Structure And Interaction: The Role Of Aromatic Residues In Protein Structure And Interactions Between Pyridoxine 5'-Phosphate Oxidase/Dopa Decarboxylase, Mohammed H. Al Mughram
Protein Structure And Interaction: The Role Of Aromatic Residues In Protein Structure And Interactions Between Pyridoxine 5'-Phosphate Oxidase/Dopa Decarboxylase, Mohammed H. Al Mughram
Theses and Dissertations
Naturally developed proteins are capable of carrying out a wide variety of molecular functions due to their highly precise three-dimensional structures, which are determined by their genetically encoded sequences of amino acids. A thorough knowledge of protein structures and interactions at the atomic level will enable researchers to get a deep foundational understanding of the molecular interactions and enzymatic processes required for cells, resulting in more effective therapeutic interventions. This dissertation intends to use structural knowledge from solved protein structures for two distinct objectives.
In the first project, we conducted a bioinformatics structural analysis of experimental protein structures using our …
Targeting Bcl-2 Family Proteins In Therapy Induced Senescent Cancer Cell Models, Wade Cook
Targeting Bcl-2 Family Proteins In Therapy Induced Senescent Cancer Cell Models, Wade Cook
Theses and Dissertations
Non-small Cell Lung Cancer (NSCLC) originates from numerous different cell types in the lungs and is among the deadliest of cancers. Head and Neck Squamous Cell Carcinomas (HNSCC) are derived from the mucosal membranes of the oral cavity, pharynx, and larynx. Both NSCLC and HNSCC are predominately caused by tobacco smoke inhalation and as such mutations in the tumor suppressor gene TP53 are common. Since similarities exist in the root cause of NSCLC and HNSCC, they may also share similarities in treatment methods. Cisplatin is a platinum-based DNA damaging agent that has been used as a cancer chemotherapy for decades. …