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Biochemistry, Biophysics, and Structural Biology
University of Missouri, St. Louis
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Multiple Puf Proteins Regulate The Stability Of Ribosome Biogenesis Transcripts, Anthony Fischer, Wendy Olivas
Multiple Puf Proteins Regulate The Stability Of Ribosome Biogenesis Transcripts, Anthony Fischer, Wendy Olivas
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Cells must make careful use of the resources available to them. A key area of cellular regulation involves the biogenesis of ribosomes. Transcriptional regulation of ribosome biogenesis factor genes through alterations in histone acetylation has been well studied. This work identifies a post-transcriptional mechanism of ribosome biogenesis regulation by Puf protein control of mRNA stability. Puf proteins are eukaryotic mRNA binding proteins that play regulatory roles in mRNA degradation and translation via association with specific conserved elements in the 3ʹ untranslated region (UTR) of target mRNAs and with degradation and translation factors. We demonstrate that several ribosome biogenesis factor mRNAs …