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Role Of Cationic Side Chains In The Antimicrobial Activity Of C18g., Eric M Kohn, David J Shirley, Lubov Arotsky, Angela M Picciano, Zachary Ridgway, Michael W Urban, Benjamin Carone, Gregory Caputo
Role Of Cationic Side Chains In The Antimicrobial Activity Of C18g., Eric M Kohn, David J Shirley, Lubov Arotsky, Angela M Picciano, Zachary Ridgway, Michael W Urban, Benjamin Carone, Gregory Caputo
Faculty Scholarship for the College of Science & Mathematics
Antimicrobial peptides (AMPs) have been an area of great interest, due to the high selectivity of these molecules toward bacterial targets over host cells and the limited development of bacterial resistance to these molecules throughout evolution. The peptide C18G has been shown to be a selective, broad spectrum AMP with a net +8 cationic charge from seven lysine residues in the sequence. In this work, the cationic Lys residues were replaced with other natural or non-proteinogenic cationic amino acids: arginine, histidine, ornithine, or diaminopropionic acid. These changes vary in the structure of the amino acid side chain, the identity of …