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Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Utilizing Crispr Cas9 To Visualize Dopamine Receptors In Caenorhabditis Elegans, Lauren Michelle Velasquez
Utilizing Crispr Cas9 To Visualize Dopamine Receptors In Caenorhabditis Elegans, Lauren Michelle Velasquez
Electronic Theses, Projects, and Dissertations
Dopamine (DA) is a neurotransmitter with imperative implications in many functions including movement, reward, and cognition. Studying the pathways of dopaminergic neurons at multiple levels allows us to understand the ways in which these systems can go wrong. We study dopamine in a model system such as the worm Caenorhabditis elegans because of its relatively simple and well-characterized nervous system. DA is involved in regulating chemosensory behaviors in worms. The purpose of this research project is to definitively answer the following question: Are the dopamine receptors DOP-1 and DOP-4 expressed in chemosensory neurons? Previous reporter assays show that neither of …
The Role Of The Erbb Signaling Pathway In Cardiovascular Progenitor Cell-Based Repair, Christopher Ramos
The Role Of The Erbb Signaling Pathway In Cardiovascular Progenitor Cell-Based Repair, Christopher Ramos
Electronic Theses, Projects, and Dissertations
Adult mammalian hearts lack self-renewal and proliferative capabilities necessary for cardiovascular regeneration. Current treatments using cardiac progenitor cells (CPCs) for cell-based repair do not restore cardiac function in patients who experience a myocardial infarction (MI). Our laboratory has been studying Islet-1+ neonatal CPCs as a promising candidate for cell-based repair due to their ability to significantly improve cardiac function after MI in sheep. The current study addresses the hypothesis that the ERBB pathway is linked to the Hippo-pathway to activate YAP1 by the involvement of an autocrine loop that upregulates neuregulin (NRG). In our sheep model of MI and cardiovascular …
Population Structure Of A Federally Endangered Plant (Astragalus Jaegerianus Munz, Fabaceae) With Limited Range Using Microsatellites, Sueann Neal
Electronic Theses, Projects, and Dissertations
Studies on population genetics examine the relationship and effects of population structure, migration, gene flow and demographic history, and are therefore important in the conservation of endangered species. Astragalus jaegerianus, a critically federally endangered species found in a geographically restricted range is investigated to determine population structure and genetic variation. Previous research on A. jaegerianus focused on DNA sequence data for cpDNA and nrDNA showed no variation. Further research on A. jaegerianus utilizing AFLP’s on the whole genome indicated substantial gene diversity and population structure consistent with geographically widespread species. AFLP research is a cost-effective process to identify levels …
Pedagogical Approaches To Enhance Q2s Conversion Teaching And Learning: Application Of The Acue Effective Practice Framework To Upper Division Biochemistry, Jason Burke
Q2S Enhancing Pedagogy
The Effective Practice Framework course by the Association of College and University Educators (ACUE), and offered through the CSUSB Teaching Resource Center (TRC), was applied to the upper division biochemistry course series (CHEM 436A and 437A) in preparation for the Q2S conversion. This essay includes five reflections on the application of enhanced pedagogical approaches curated from a total of twenty-five. The enhanced pedagogies covered in the course are: designing and effective course and class; establishing a productive learning environment; using active learning techniques; promoting higher-order thinking; and assessing to inform instruction and promote learning. The reflections that follow have been …
Influencing Pathways That Cause Metastasis And Stemness In Epithelial Ovarian Cancer, Alyse Lynn Huisken-Hill
Influencing Pathways That Cause Metastasis And Stemness In Epithelial Ovarian Cancer, Alyse Lynn Huisken-Hill
Electronic Theses, Projects, and Dissertations
Ovarian cancer is the fifth leading cause of cancer death in women between the ages of 35 and 74. With 22 thousand new cases and 15 thousand deaths annually ovarian cancer is among the most deadly cancers with a death to incidence ratio of 68%. With 70% of cases High Grade Serous Ovarian Carcinoma (HGSOC) is the most common type of ovarian cancer and causes 90% of ovarian cancer deaths. 80% of patients have reoccurrence within five years and only 15-30% of patients with recurrent metastatic ovarian cancer respond to current therapies, chemotherapy and surgery. One reason for the high …
Elucidating The Role Of Dopamine In The Avoidance Response Of Caenorhabditis Elegans Utilizing Microfluidics, Patricia Frances Turturro
Elucidating The Role Of Dopamine In The Avoidance Response Of Caenorhabditis Elegans Utilizing Microfluidics, Patricia Frances Turturro
Theses Digitization Project
This study looks at dopamine modulation of ASH neurons, which are part of the avoidance circuit of C. elegans, and their response to water soluble stimuli. Because nematodes such as Caenorhabditis elegans utilize dopamine at the molecular and cellular level in much the same way as mammals, they offer researchers a unique opportunity to study the mechanisms of dopamine signaling.
Dopaminergic Modulation Of Glutamate Signaling In Caenorhabditis Elegans, Melvin Suman Baidya
Dopaminergic Modulation Of Glutamate Signaling In Caenorhabditis Elegans, Melvin Suman Baidya
Theses Digitization Project
This study investigates how DA (dopamine) modulates GLU (glutamate) signaling at the interneuron level of the C. elegans avoidance circuit in response to the noxious chemical 1-octanol. Many neural processes involved in addiction, exhibit cellular mechanisms using the neurotransmitters dopamine and glutamate along with their intracellular and genomic targets.
Cell Type Difference In Influenza A Viral Mrna Nuclear Export, Sean William Larsen
Cell Type Difference In Influenza A Viral Mrna Nuclear Export, Sean William Larsen
Theses Digitization Project
The focus of this thesis research was to clarify the role of host Nxf1 in influenza viral mRNA nuclear export. This study aims to define the nuclear mRNA export pathways of influenza viral mRNA. If viral mRNAs are discovered to utilize neither known mRNA nuclear export pathway this would indicate the mRNA exports via undefined mRNA nuclear export pathway. This might be an atypical pathway not utilized by many host mRNAs and thus might reveal novel antiviral target. 293T (Human embryonic kidney cells) and A549 (Human lung epithelial) cells were purchased from ATCC American Tissue Culture Collection.
The Effects Of Leptin And Thyroid Hormone On Metabolism And Lipid Trafficking In The Liver And Adipose Tissue Of Ob/Ob Mice, Candace Michelle Reno
The Effects Of Leptin And Thyroid Hormone On Metabolism And Lipid Trafficking In The Liver And Adipose Tissue Of Ob/Ob Mice, Candace Michelle Reno
Theses Digitization Project
The purpose of this project was to study how the key metabolic hormones, insulin, leptin, and thyroid hormone alter metabolic pathways and lipid and glucose trafficking in order to find possible therapies for treatment for obesity and its complications.
The Influence Of Leptin On Metabolic Expenditure And Thermogenesis During Thyroid Hormone (T₃) Suppression In The Obese (Ob/Ob) Mouse, Brian Kimball Underhill
The Influence Of Leptin On Metabolic Expenditure And Thermogenesis During Thyroid Hormone (T₃) Suppression In The Obese (Ob/Ob) Mouse, Brian Kimball Underhill
Theses Digitization Project
No abstract provided.
Effect Of Thyroid Hormone On Formation Of The Nsf Fusion Complex In Normal And Obese Diabetic (Db/Db) Mice, Felipe Barajas Galicia
Effect Of Thyroid Hormone On Formation Of The Nsf Fusion Complex In Normal And Obese Diabetic (Db/Db) Mice, Felipe Barajas Galicia
Theses Digitization Project
No abstract provided.
Anti-Neoplastic Actions In Vivo And In Vitro By Non-Toxic Natural Products From Chara Globularis, A Multicellular Green Alga, Abdessalam Sherif
Anti-Neoplastic Actions In Vivo And In Vitro By Non-Toxic Natural Products From Chara Globularis, A Multicellular Green Alga, Abdessalam Sherif
Theses Digitization Project
No abstract provided.