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Biochemistry, Biophysics, and Structural Biology

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Selected Works

Articles 1 - 9 of 9

Full-Text Articles in Life Sciences

Synthesis And Evaluation Of Novel Silica Hydride-Based Stationary Phases For Bioanalytical Application, Seiichiro Watanabe May 2019

Synthesis And Evaluation Of Novel Silica Hydride-Based Stationary Phases For Bioanalytical Application, Seiichiro Watanabe

Seiichiro Watanabe

Most HPLC columns are packed with silanol-rich (Si-OH) type-B silica material that often participates in undesired electrostatic interactions with the analyte solutes and produces poor peak shape [1,2]. These silanols are also known to facilitate surface hydration necessary for HILIC retention mode for polar analyte molecules. However, the hydrated surface composition can easily fluctuate, and thus results in a poor reproducibility and requires lengthy equilibration step. In this study, four novel stationary phases have been developed by using the TYPE-CTM Silica Hydride material, which has replaced up to 95% of the surface silanols with silicon-hydride (Si-H) groups. One of the …

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Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri Dec 2013

Requirements Of Rab5 Activity In Highly Invasive Breast Cancer Cell Lines, Nicole Porther, M Alejandro Barbieri

Nicole Porther

Rab5 expression in cancer has been associated with the disease progression and prognosis. We have previously shown that growth factor-directed cell invasion and migration was dependent on Rab5 activation in non-invasive breast cancer cells. However, hardly any data is available regarding the role of Rab5 in invasive cells in the presence of growth factor.  In our present study, we report that the invasive and migratory properties of the highly invasive breast cancer cell line, MDAMB-231, were abrogated in cells expressing the inactive (GDP-bound) form of Rab5 irrespective of growth factor stimulation; while the invasive potential of breast cancer cell lines …

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Assessing Tissue Characterization Of Abdominal Organs Using Fuzzy C-Means Cluster Analysis Of Color- Fusion Mr Images, Terrance D. Weeden, H. Keith Brown Apr 2013

Assessing Tissue Characterization Of Abdominal Organs Using Fuzzy C-Means Cluster Analysis Of Color- Fusion Mr Images, Terrance D. Weeden, H. Keith Brown

Terrance Weeden

Color fusion MRI is being investigated for its value in automatic segmentation of tissues. An existing color fusion MRI data set of the liver, pancreas, and kidney of a normal male volunteer was analyzed both visually and statistically. Automatic tissue segmentation can allow better differentiation of abdominal pathologies, as well as pathologies associated with other organs. My research hypothesis is that fuzzy c-means clustering can be used to quantify the confidence levels of the correct classification of renal, pancreatic, and hepatic tissues visualized by the color fusion MRI method. Results from data show that fuzzy c-means clustering can be used …

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Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri Dec 2012

Rab5 Function In Breast Cancer Cells, Nicole Porther, M Alejandro Barbieri

Nicole Porther

Metastasis is characterized pathologically by cell invasion, proliferation, migration and angiogenesis. Growth factors, which include epithelial growth factor (EGF), insulin growth factors I and II (IGFI and IGFII); have been associated with most if not all of the features of metastasis.  Our study has highlighted the possible role growth factors may have in mediating cancer metastasis via Rab GTPses.  We determined that the invasive and migratory properties of breast cancer cells were abrogated in cell lines that only expressed the inactive (GDP-bound) form of Rab 5 irrespective of growth factor stimulation. Breast cancer cell lines expressing the wild type and …

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Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt Oct 2012

Libraries At The University Of Massachusetts Amherst: Seeking An International Perspective, Maxine G. Schmidt

Maxine G Schmidt

Presentation delivered to librarians in China, Japan and South Korea as part of my sabbatical research on the use of libraries by Asian students in their home countries.

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Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt Sep 2011

Arcane Secrets Of The Umass Libraries, Maxine G. Schmidt

Maxine G Schmidt

No abstract provided.

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An Entrepreneurial Approach To Librarianship, Flora G. Shrode, Jennifer R. Duncan, Wendy Holliday Apr 2010

An Entrepreneurial Approach To Librarianship, Flora G. Shrode, Jennifer R. Duncan, Wendy Holliday

Flora Shrode

Librarians from Utah State University explain recent efforts to encourage subject librarians to take a more holistic view of their roles. We are shifting from a traditional emphasis primarily on collection development and refocusing on natural connections between collections, instruction, liaison, and reference service. The poster provides background about Utah State University’s situation and explains our approach to analyzing local needs and culture to inform development of a new organizational structure. We describe our vision of subject librarianship, the process by which we assessed librarians’ ideas and goals for performing as subject librarians, and the actions we are taking to …

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Umass Libraries 2009, Maxine G. Schmidt Jan 2009

Umass Libraries 2009, Maxine G. Schmidt

Maxine G Schmidt

No abstract provided.

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Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt Jan 2008

Important, But Odd And Obscure, Reasons To Use The Library, Maxine G. Schmidt

Maxine G Schmidt

No abstract provided.

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