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Post-Lysosomal Cholesterol Trafficking: Novel Tools And Insights, Mckenna Rae Feltes
Post-Lysosomal Cholesterol Trafficking: Novel Tools And Insights, Mckenna Rae Feltes
Arts & Sciences Electronic Theses and Dissertations
Cholesterol is an essential mammalian lipid. It is a major component of cellular membranes, a precursor molecule for the synthesis of hormones and bile acids, and a regulator of protein function. Although cholesterol is synthesized, de novo, in the endoplasmic reticulum, cells principally meet cholesterol requirements through uptake of lipoprotein particles. Lipoprotein-derived cholesterol is transported to the lysosome where it is transferred from the soluble lysosomal protein, NPC2, to limiting-lysosomal membrane protein NPC1. Cholesterol is then re-distributed to other cellular membranes in order to fulfill organellar cholesterol requirements; however, the cellular machineries involved in coordinating this distribution are poorly characterized. …