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Regulation Of Line-1 In Developing Oocytes And The Impact On The Ovarian Reserve, Rose Besen-Mcnally
Regulation Of Line-1 In Developing Oocytes And The Impact On The Ovarian Reserve, Rose Besen-Mcnally
Electronic Theses and Dissertations
In humans and mice, the ovarian reserve (OR) is established during a lengthy process that starts during early embryogenesis with germ cell specification and culminates in the first weeks after birth when primordial follicles (PF) are formed. OR establishment is an important process which influences the fertile lifespan and fecundity of the individual. Fetal oocyte attrition (FOA) has been identified as a critical developmental event that regulates how many oocytes survive and contribute to the final OR. In addition to FOA, OR size and quality also depend on efficiency of meiotic recombination. Chromosome asynapsis and unrepaired meiotic double-strand breaks (DSB) …