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Articles 1 - 15 of 15
Full-Text Articles in Life Sciences
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Sandra Jones
This paper examined womens counterfactualthoughts in response to hypothetical scenarios aboutearly versus late breast cancer diagnoses.Womenaged 50 and over (N=29) read hypotheticalscenarios about the experience of fictitious womenof mammography screening age and completedcounterfactual statements from the protagonistsperspective.In two scenarios, the protagonist failedto attend mammography screening regularly andwas diagnosed with advanced breast cancer; thethird scenario depicted a woman who hadmammograms biennially and received an early-stagebreast cancer diagnosis.Consistent with pastliterature on counterfactual thinking, participantsgenerated exclusively upward counterfactuals fromthe two late-diagnosis scenarios, and predominantlydownward counterfactuals from the early-diagnosisscenario.Furthermore, participants primarilyfocussed on what the protagonist could personallyhave done differently to lead to a differentoutcome.Hence …
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Jimmy Chun Yu Louie
In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …
The Danger Of Applying Uniform Clincal Policies Across Populations: The Case Of Breast Cancer In American Indians, Paul Nutting, Ned Calonge, Donald Iverson, Larry Green
The Danger Of Applying Uniform Clincal Policies Across Populations: The Case Of Breast Cancer In American Indians, Paul Nutting, Ned Calonge, Donald Iverson, Larry Green
Don C. Iverson
OBJECTIVES. This study examined the implications of annual screening mammography for cost and mortality in American Indian populations with differing baseline breast cancer rates. METHODS. A decision tree compared annual screening mammography and screening clinical breast examination with referral for diagnostic mammography when appropriate. The decision tree was constructed to examine the effect of different base-line cancer rates, stage at diagnosis, and stage-specific survival. Outcomes included 5-year relative survival, deaths prevented at 5 years, cost per death prevented, and total costs. RESULTS. The findings suggest that the total cost of breast cancer is 3.6 times higher with the screening mammography …
Feasibility Studies Of Low-Fat Diet To Prevent Or Retard Breast Cancer, P Greenwald, C Clifford, R Butrum, Donald Iverson
Feasibility Studies Of Low-Fat Diet To Prevent Or Retard Breast Cancer, P Greenwald, C Clifford, R Butrum, Donald Iverson
Don C. Iverson
No abstract provided.
Australian Women's Awareness Of Breast Cancer Symptoms And Responses To Potential Symptoms, Sandra Jones, Parri Gregory, Caroline Nehill, Lance Barrie, Karen Luxford, A. Nelson, Helen Zorbas, Donald Iverson
Australian Women's Awareness Of Breast Cancer Symptoms And Responses To Potential Symptoms, Sandra Jones, Parri Gregory, Caroline Nehill, Lance Barrie, Karen Luxford, A. Nelson, Helen Zorbas, Donald Iverson
Don C. Iverson
Poor awareness of breast cancer symptoms has been associated with patient delay in seeking help; thus reduced survival, more aggressive treatment, and fewer treatment choices. The aim of this study was to develop a representative picture of Australian women’s knowledge of symptoms, experienced potential symptoms, and behavioral responses. A general population sample of approximately 3,000 women aged 30–69 completed a telephone survey; results were compared to previous surveys conducted in 1996 and 2003. The most commonly cited potential symptom of breast cancer was a lump in the breast, identified by 86% of respondents (an increase from 75% in 2003). Other …
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Don C. Iverson
Background Numerous studies have shown that the majority of women overestimate both their own risk and the populations’ risk of developing breast cancer. A number of factors have been found to correlate with perceived risk. Methods This paper reports on a telephone survey of a nationally representative sample of approximately 3,000 Australian women aged 30 to 69 years, conducted in 2007, and compares the findings with those of a similar survey conducted in 2003. Results There was a clear tendency for respondents to overestimate the proportion of women who will develop breast cancer during their lifetime. Approximately half the respondents …
Relationship Between Breast-Feeding And Adiposity In Infants And Pre-School Children, Bamini Gopinath, Indhu Subramanian, Victoria M. Flood, Louise A. Baur, Natalie Pfund, George Burlutsky, Paul Mitchell
Relationship Between Breast-Feeding And Adiposity In Infants And Pre-School Children, Bamini Gopinath, Indhu Subramanian, Victoria M. Flood, Louise A. Baur, Natalie Pfund, George Burlutsky, Paul Mitchell
Faculty of Health and Behavioural Sciences - Papers (Archive)
Objectives: We aimed to establish associations of duration of breast-feeding with mean BMI and waist circumference, as well as the likelihood of being overweight/ obese, during early childhood. Design: Cross-sectional, population-based study. Height, weight and waist circumference were measured and BMI calculated. Interviewer-administered questionnaire determined whether the child was ever breast-fed and the duration of breast-feeding. Setting: Sydney, Australia. Subjects: Infants and pre-school children (n 2092) aged 1-6 years were examined in the Sydney Paediatric Eye Disease Study during 2007-2009. Results: Of the children aged 1-6 years, 1270 had been breast-fed compared with 822 who were never breast-fed. After multivariable …
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Australian Women's Perceptions Of Breast Cancer Risk Factors And The Risk Of Developing Breast Cancer, Sandra C. Jones, Christopher A. Magee, Lance R. Barrie, Donald C. Iverson, Parri Gregory, Emma L. Hanks, Anne E. Nelson, Caroline L. Nehill, Helen M. Zorbas
Faculty of Health and Behavioural Sciences - Papers (Archive)
Background Numerous studies have shown that the majority of women overestimate both their own risk and the populations’ risk of developing breast cancer. A number of factors have been found to correlate with perceived risk. Methods This paper reports on a telephone survey of a nationally representative sample of approximately 3,000 Australian women aged 30 to 69 years, conducted in 2007, and compares the findings with those of a similar survey conducted in 2003. Results There was a clear tendency for respondents to overestimate the proportion of women who will develop breast cancer during their lifetime. Approximately half the respondents …
Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sex Steroid Metabolism Polymorphisms And Mammographic Density In Pre- And Early Perimenopausal Women, Carolyn J. Crandall, Mary E. Sehl, Sybil L. Crawford, Ellen B. Gold, Laurel A. Habel, Lesley M. Butler, Mary Fran R. Sowers, Gail A. Greendale, Janet S. Sinsheimer
Sybil L. Crawford
INTRODUCTION : We examined the association between mammographic density and single-nucleotide polymorphisms (SNPs) in genes encoding CYP1A1, CYP1B1, aromatase, 17beta-HSD, ESR1, and ESR2 in pre- and early perimenopausal white, African-American, Chinese, and Japanese women. METHODS : The Study of Women's Health Across the Nation is a longitudinal community-based cohort study. We analyzed data from 451 pre- and early perimenopausal participants of the ancillary SWAN Mammographic Density study for whom we had complete information regarding mammographic density, genotypes, and covariates. With multivariate linear regression, we examined the relation between percentage mammographic breast density (outcome) and each SNP (primary predictor), adjusting for …
Effects Of High And Low Breast Support On Breast Kinematics And Kinetics During Treadmill Running, Deirdre Mcghee, Julie R. Steele, William J. Zealey
Effects Of High And Low Breast Support On Breast Kinematics And Kinetics During Treadmill Running, Deirdre Mcghee, Julie R. Steele, William J. Zealey
Faculty of Health and Behavioural Sciences - Papers (Archive)
Results: The mean vertical component of the peak bra/breast spring force during treadmill running was greatest during the downward breast trajectory and was approximately 30% less in the high breast support condition (13 N ± 7 N) compared to the low support condition (17 N ± 10 N). This force reduction was accompanied by a 300% decrease in breast and bra discomfort. Conclusion: Wearing a well-fitted supportive sports bra is recommended for females with large breasts to reduce the breast forces and, in tum, exercise induced breast and bra discomfort during physical activity such as treadmill running.
Education Improves Bra Knowledge And Fit, And Level Of Breast Support In Adolesent Female Athletes: A Cluster-Randomised Trial, Deirdre Mcghee, Julie R. Steele, Bridget J. Munro
Education Improves Bra Knowledge And Fit, And Level Of Breast Support In Adolesent Female Athletes: A Cluster-Randomised Trial, Deirdre Mcghee, Julie R. Steele, Bridget J. Munro
Faculty of Health and Behavioural Sciences - Papers (Archive)
Questions: Can an education booklet handed out by a physiotherapist improve bra knowledge and fit, and level of breast support, of bras worn by adolescent female athletes? Design: Cluster-randomised trial with intention-to-treat analysis. Participants: 115 adolescent females from four regional sporting academies aged 16 yr (SD 1) and with an average Australian bra size of 12B. Intervention: The experimental group received an education booklet on bra fit and breast support from a sports physiotherapist. The control group received no intervention. Outcome measures: The primary outcome was bra knowledge measured by a questionnaire. Secondary outcomes were a pass on the Bra …
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Polysaccharopeptide Enhances The Anticancer Activity Of Doxorubicin And Etoposide On Human Breast Cancer Cells Zr-75-30, Jennifer Man-Fan Wan, Wai Hung Sit, Jimmy Chun Yu Louie
Faculty of Health and Behavioural Sciences - Papers (Archive)
In search of natural bioactive microbial compounds with adjuvant properties, we have previously showed that the polysaccharopeptide (PSP), isolated from Chinese medicinal mushroom Coriolus versicolor, was able to enhance the cytotoxicity of certain S-phase targeted-drugs on human leukemic HL-60 cells via some cell-cycle and apoptotic-dependent pathways. The present study aimed to investigate whether the synergism of mechanisms of PSP with certain chemotherapeutic drugs also applies to human breast cancer. PSP treatment enhanced the cytotoxicity of doxorubicin (Doxo), etoposide (VP-16) but not cytarabine (Ara-C). Bivariate bromodeoxyuridine (BrdUrd)/DNA flow cytometry analysis estimated a longer DNA synthesis time (Ts) for the PSP treated …
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Plasminogen Binding And Activation At The Breast Cancer Cell Surface: The Integral Role Of Urokinase Activity, Gillian E. Stillfried, Darren Saunders, Marie Ranson
Faculty of Health and Behavioural Sciences - Papers (Archive)
INTRODUCTION: The regulation of extracellular proteolytic activity via the plasminogen activation system is complex, involving numerous activators, inhibitors and receptors. Previous studies on monocytic and colon cell lines suggest that plasmin pre treatment can increase plasminogen binding, allowing the active enzyme to generate binding sites for its precursor. Other studies have shown the importance of pre formed receptors such as annexin II heterotetramer. However, few studies have utilised techniques which exclusively characterise cell surface events and these mechanisms have not been investigated at the breast cancer cell surface. METHODS: We have studied plasminogen binding to MCF 7 in which uPAR …
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Counterfactual Thinking In Response To Hypothetical Breast Cancer Scenarios: A Pilot Study, Amy Y. Chan, Sandra C. Jones, Karen T. Rich
Faculty of Health and Behavioural Sciences - Papers (Archive)
This paper examined womens counterfactualthoughts in response to hypothetical scenarios aboutearly versus late breast cancer diagnoses.Womenaged 50 and over (N=29) read hypotheticalscenarios about the experience of fictitious womenof mammography screening age and completedcounterfactual statements from the protagonistsperspective.In two scenarios, the protagonist failedto attend mammography screening regularly andwas diagnosed with advanced breast cancer; thethird scenario depicted a woman who hadmammograms biennially and received an early-stagebreast cancer diagnosis.Consistent with pastliterature on counterfactual thinking, participantsgenerated exclusively upward counterfactuals fromthe two late-diagnosis scenarios, and predominantlydownward counterfactuals from the early-diagnosisscenario.Furthermore, participants primarilyfocussed on what the protagonist could personallyhave done differently to lead to a differentoutcome.Hence …
A Structural Basis For Differential Cell Signalling By Pai-1 And Pai-2 In Breast Cancer Cells, Marie Ranson, David Croucher, Darren Saunders, Gillian E. Stillfried
A Structural Basis For Differential Cell Signalling By Pai-1 And Pai-2 In Breast Cancer Cells, Marie Ranson, David Croucher, Darren Saunders, Gillian E. Stillfried
Faculty of Health and Behavioural Sciences - Papers (Archive)
PAI-1 and PAI-2 (plasminogen-activator inibitor types 1 and 2) are inhibitors of cell surface uPA (urokinase plasminogen activator). However, tumour expression of PAI-1 and PAI-2 correlates with poor compared with good patient prognosis in breast cancer respectively. This biological divergence may be related to additional functional roles of PAI-1. For example, the inhibition of uPA by PAI-1 reveals a cryptic high-affinity site within the PAI-1 moiety for the VLDLr (very-low-density-lipoprotein receptor), which sustains cell signalling events initiated by binding of uPA to its receptor. These interactions and subsequent signalling events promote proliferation of breast cancer cells. Biochemical and structural analyses …