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Articles 1 - 6 of 6
Full-Text Articles in Other Engineering
Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed
Representation Learning For Chemical Activity Predictions, Mohamed S. Ayed
Dissertations, Theses, and Capstone Projects
Computational prediction of a phenotypic response upon the chemical perturbation on a biological system plays an important role in drug discovery and many other applications. Chemical fingerprints derived from chemical structures are a widely used feature to build machine learning models. However, the fingerprints ignore the biological context, thus, they suffer from several problems such as the activity cliff and curse of dimensionality. Fundamentally, the chemical modulation of biological activities is a multi-scale process. It is the genome-wide chemical-target interactions that modulate chemical phenotypic responses. Thus, the genome-scale chemical-target interaction profile will more directly correlate with in vitro and in …
Design Of Control Logic And The Human-Machine Interface For A Demonstration Plant Growth Chamber Implemented On A Programmable Logic Controller, Rachael Koehler
Design Of Control Logic And The Human-Machine Interface For A Demonstration Plant Growth Chamber Implemented On A Programmable Logic Controller, Rachael Koehler
Biological and Agricultural Engineering Undergraduate Honors Theses
This honors thesis covers the planning, development, and implementation of system controls and human-machine interface (HMI) for a demonstration plant growth chamber. The work is a continuation of an ongoing project to be used as an educational and recruiting tool manifesting the skills acquired from the Biological and Agricultural Engineering Department at the University of Arkansas’ College of Engineering. This work includes emergency controls, overall design interface, and controls for both the aeration and lighting subsystems of the growth chamber. Overall design interface controls established included development of two user modes, Administrator and Visitor. The Administrator user will have full …
Bio Circuits For Evolutionary Biotech, Camilo Toruno
Bio Circuits For Evolutionary Biotech, Camilo Toruno
ENGS 86 Independent Projects (AB Students)
The field of bioengineering has much promise for renewable chemical production, bioremediation, and of course medical applications. Developing new useful microorganisms is extremely time and capital intensive, typically taking 50 million USD and eight years. This is due in large part to the low throughput techniques that are characteristic of the field of metabolic engineering. Here we describe the modification of an existing synthetic biosensor to measure the pharmaceutical dopamine, and the use of a circuit simulator Cadence to predict improvements to the biosensor. This biosensor paired with directed evolution techniques could reach throughputs of 5 million cells per day …
Calcium Phosphate As A Key Material For Socially Responsible Tissue Engineering, Vuk Uskoković, Victoria M. Wu
Calcium Phosphate As A Key Material For Socially Responsible Tissue Engineering, Vuk Uskoković, Victoria M. Wu
Pharmacy Faculty Articles and Research
Socially responsible technologies are designed while taking into consideration the socioeconomic, geopolitical and environmental limitations of regions in which they will be implemented. In the medical context, this involves making therapeutic platforms more accessible and affordable to patients in poor regions of the world wherein a given disease is endemic. This often necessitates going against the reigning trend of making therapeutic nanoparticles ever more structurally complex and expensive. However, studies aimed at simplifying materials and formulations while maintaining the functionality and therapeutic response of their more complex counterparts seldom provoke a significant interest in the scientific community. In this review …
Laminar Flow In Mini-Fluidics Channels Assembly And Its Application In Zebra Fish Embryo Research, Radek Glaser
Laminar Flow In Mini-Fluidics Channels Assembly And Its Application In Zebra Fish Embryo Research, Radek Glaser
Radek Glaser
A Mini-Fluidics system was designed to facilitate the muscle growth of the Zebra Fish embryos. This experimental device is made of peristaltic pump, inflow/outflow manifolds, fluid storage tank, series of valves and flexible pipes and the main plate with six mini channels. These closed channels provide pathways for an extremely laminar flow. The Zebra Fish embryos are placed in the channels and exposed to the forces present in the fluid.
Analysis Of Cutthroat Flume Discharge Ratings, Liyan Ren
Analysis Of Cutthroat Flume Discharge Ratings, Liyan Ren
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Sixteeen sets of original laboratory data collected by many investigators for various Cutthroat flume sizes are thoroughly reviewed and organized. Best-fit discharge parameters are obtained by performing the free-flow analysis and the submerged-flow analysis. Then, the transition submergence can be calculated. Afterwards, the unified free-flow and submerged-flow discharge parameters are developed for each flume size in order to generalize the calibrations for Cutthroat flumes. This is a very tedious process requiring a trial-and-error approach. Finally, comparisons are made of the measured laboratory discharges with the predicted discharges for both free flow and submerged flow using both the best-fit and the …