Operations Research, Systems Engineering and Industrial Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Developing Leading And Lagging Indicators To Enhance Equipment Reliability In A Lean System, Dhanush Agara Mallesh

Masters Theses

With increasing complexity in equipment, the failure rates are becoming a critical metric due to the unplanned maintenance in a production environment. Unplanned maintenance in manufacturing process is created issues with downtimes and decreasing the reliability of equipment. Failures in equipment have resulted in the loss of revenue to organizations encouraging maintenance practitioners to analyze ways to change unplanned to planned maintenance. Efficient failure prediction models are being developed to learn about the failures in advance. With this information, failures predicted can reduce the downtimes in the system and improve the throughput.

The goal of this thesis is to predict …

Explorations Into Machine Learning Techniques For Precipitation Nowcasting, Aditya Nagarajan

Masters Theses

Recent advances in cloud-based big-data technologies now makes data driven solutions feasible for increasing numbers of scientific computing applications. One such data driven solution approach is machine learning where patterns in large data sets are brought to the surface by finding complex mathematical relationships within the data. Nowcasting or short-term prediction of rainfall in a given region is an important problem in meteorology. In this thesis we explore the nowcasting problem through a data driven approach by formulating it as a machine learning problem.

State-of-the-art nowcasting systems today are based on numerical models which describe the physical processes leading to …

A Bounded Actor-Critic Algorithm For Reinforcement Learning, Ryan Jacob Lawhead

Masters Theses

"This thesis presents a new actor-critic algorithm from the domain of reinforcement learning to solve Markov and semi-Markov decision processes (or problems) in the field of airline revenue management (ARM). The ARM problem is one of control optimization in which a decision-maker must accept or reject a customer based on a requested fare. This thesis focuses on the so-called single-leg version of the ARM problem, which can be cast as a semi-Markov decision process (SMDP). Large-scale Markov decision processes (MDPs) and SMDPs suffer from the curses of dimensionality and modeling, making it difficult to create the transition probability matrices (TPMs) …

A New Reinforcement Learning Algorithm With Fixed Exploration For Semi-Markov Decision Processes, Angelo Michael Encapera

Masters Theses

"Artificial intelligence or machine learning techniques are currently being widely applied for solving problems within the field of data analytics. This work presents and demonstrates the use of a new machine learning algorithm for solving semi-Markov decision processes (SMDPs). SMDPs are encountered in the domain of Reinforcement Learning to solve control problems in discrete-event systems. The new algorithm developed here is called iSMART, an acronym for imaging Semi-Markov Average Reward Technique. The algorithm uses a constant exploration rate, unlike its precursor R-SMART, which required exploration decay. The major difference between R-SMART and iSMART is that the latter uses, in addition …