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Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering

Response Of Phlebotomine Sand Flies To Light-Emitting Diode-Modified Light Traps In Southern Egypt, D. F. Hoel, Emad Y. Fawaz, J.E Butler, N. Watany, S. S. El-Hossary, J. Villinski Dec 2007

Response Of Phlebotomine Sand Flies To Light-Emitting Diode-Modified Light Traps In Southern Egypt, D. F. Hoel, Emad Y. Fawaz, J.E Butler, N. Watany, S. S. El-Hossary, J. Villinski

U.S. Navy Research

Centers For Disease Control and Prevention (CDC) light traps were modified for use with light-emitting diodes (LED) and compared against a control trap (incandescent light) to determine the effectiveness of blue, green, and red lights against standard incandescent light routinely used for sand fly surveillance. Light traps were baited with dry ice and rotated through a 4 x 4 Latin square design during May, June, and July, 2006. Trapping over 12 trap nights yielded a total of 2,298 sand flies in the village of Bahrif, 6 km north of Aswan on the east bank of the Nile River in southern …


Acuta Enews December 2007, Vol.36, No. 12 Dec 2007

Acuta Enews December 2007, Vol.36, No. 12

ACUTA Newsletters

ln This lssue

From the President............. Walt Magnussen, Texas A&M Univ., ACUTA President

Check lt Out: RFls/RFPs, Job Postings, Press Releases

Tech Talk: Mash Up Your Data and Serve lt with Gravy................ Kevin Tanzillo, Dux PR

Board Report.................... Riny Ledgerwood, Son Diego State Univ., ACUTA, Sec../Treasurer

DC Update............ Jeanne Jansenius, Sewanee, The University of the South

lnfo Links............... Randy Hayes, Univ, of Northern lowa

Why Do We Do What We Do?...................... Bill Farris, Univ. of Kansas

FYI: Useful Information from Campus............. Eric Weil, Student Monitor

Nominations Open for Institutional Excellence Awards............... Carmine Piscopo, Providence College

Thanks to 2007 Sponsors

PAETEC …


Acuta Enews November 2007, Vol.36, No. 11 Nov 2007

Acuta Enews November 2007, Vol.36, No. 11

ACUTA Newsletters

In This Issue

From ACUTA Headquarters.................. Jeri A. Semer, CAE, ACUTA Executive Director

Tech Talk: There Are Lots of Zeroes Behind a Yottabit............ Kevin Tanzillo, Dux PR.

DC Update............... Jeanne Jansenius, Sewanee, The University of the South

lnfo Links ............... Randy Hayes, Univ. of Northern lowa

Board Report............... Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

ls Your lP Phone Counterfeit?..................... Gary Audin, Delphi

FYI: Useful lnformation from Campus.................. Eric Weil, Student Monitor

Thanks to 2007 Exhibitors

Welcome New Members

Check lt Out: RFls/RFPs, Job Postings, Press Releases


Acuta Enews October 2007, Vol.36, No. 10 Oct 2007

Acuta Enews October 2007, Vol.36, No. 10

ACUTA Newsletters

ln This lssue

From the President .............. Watt Magnussen, Ph.D., Texas A&M University

Tech Talk: Makin' Bacn: Another Way to Clog lnboxes............... Kevin Tanzillo, Dux PR

DC Update............... Jeanne Jansenius, Sewanee, The University of the South

Board Report ................. Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

New Faces at ACUTA

Web Tip: Listserv Reminders ................. Aaron Fuehrer, ACUTA Information Technology Mgr.

Member Sites to See

lnfo Links Randy Hayes, Univ. of Northern lowa

lnvite Your Vendors to Join ACUTA............. Amy Burton, ACUTA Mgr., Membership Mktg.& Corp. Relations

Welcome New Members

Check lt Out: RFls/RFPs, Job Postings, Press Releases


Semester Project For Engineering Management, Paul Savory Oct 2007

Semester Project For Engineering Management, Paul Savory

Industrial and Management Systems Engineering: Instructional Materials

This is the semester-project for my IMSE 405/805 course on Engineering Management at the University of Nebraska-Lincoln. This team-based project required students to develop an operational plan (facility layout, required staffing, company operating policies, company benefits program) for a specified product.


Acuta Enews September 2007, Vol.36, No. 9 Sep 2007

Acuta Enews September 2007, Vol.36, No. 9

ACUTA Newsletters

ln This lssue

From ACUTA Headquarters ................. Jeri A. Semer, CAE, ACUTA Executive Director

lnfo Links.................. Randy Hayes, Univ. of Northern lowa

Tech Talk: Change May Be Constant, But at Least lt's Gradual.............. Kevin Tanzilto, Dux PR

DC Update................ Jeanne Jansenius, Sewanee, The University of the South

Board Report..................... Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

Telecommunications Enhancing School Safety............. Gerard Shallo, XTEND Communications

Check lt Out: RFls/RFPs, Job Postings, Press Releases

ACUTA Resources Make Membership a Great Value ................. Patty Benton, University of Alabama

FYI: Useful lnformation from the Campus Student Monitor

Treasure Chest Winners

Welcome New Members …


Acuta Enews August 2007, Vol. 36, No. 8 Aug 2007

Acuta Enews August 2007, Vol. 36, No. 8

ACUTA Newsletters

ln This lssue

From the President ............. Walt Magnussen, Ph,D., Texas A&M University

Tech Talk: ls This a Phone That You Want on Your Network? ............ Kevin Tanzillo, Dux PR 2 ACUTA Resources Make Membership a Great Value

DC Update ............... Jeanne Jansenius, Sewonee, The University of the South

Board Report............... Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

IPFIX Standard (NetFlow) and lT Staff |mpact.............. Gary Audin, Delphi lnc.

Check lt Out: RFls/RFPs, Job Postings, Press Releases

FYI: Useful lnformation from the Campus................. Student Monitor

Web Tip: Address Change for ACUTA Listservs ..... Aaron Fuehrer, ACUTA lnformation Technology Mgr. …


Understanding Sub-20 Nm Breakdown Behavior Of Liquid Dielectrics, Kumar R. Virwani, Ajay P. Malshe, Kamlakar P. Rajurkar Jul 2007

Understanding Sub-20 Nm Breakdown Behavior Of Liquid Dielectrics, Kumar R. Virwani, Ajay P. Malshe, Kamlakar P. Rajurkar

Department of Industrial and Management Systems Engineering: Faculty Publications

Nanoscale confinement of dielectric molecules is expected to influence their breakdown mechanism in applications such as nanoprobe based machining, molecular electronics, and other related technologies. This Letter presents the first experimental study of the breakdown of nonpolar, nonthiolated liquid dielectrics in the nanometer regime and develops a field emission assisted avalanche based approach to model such behavior. The studies show that dielectric breakdown in the sub-20 nm regime is independent of the cathode materials and is dominated by the electron emission and atomic cluster migration due to the ‘‘sub-20 nm scale confinement of the liquid dielectric.’’


Acuta Enews July 2007, Vol. 36, No. 7 Jul 2007

Acuta Enews July 2007, Vol. 36, No. 7

ACUTA Newsletters

ln This lssue

Meet the Board for 2007-08

From ACUTA Headquarters: Member Anniversaries............... Jeri A. Semer, CAE, Executive Director

Tech Talk: The Passing of Passwords................... Kevin Tanzillo, Dux PR

DC Update .................. Jeanne Jansenius, Sewanee, The University of the South

Check lt Out: RFls/RFPs, Job Postings, Press Releases

Board Report ................. Riny Ledgerwood, Son Diego State Univ., ACUTA Sec./Treasurer

FYI: Useful lnformation from the campus............... Student Monitor

Level 3 Completes lnternet2 Optical Network implementation

Member Sites to See

lnfo Links................... Randy Hayes, Univ. of Northern lowa

Terri Robinett Wins Room at the Conference

$5250,000 Emergency & Event Notification "Grants,, from …


Acuta Enews June 2007, Vol. 36, No. 6 Jun 2007

Acuta Enews June 2007, Vol. 36, No. 6

ACUTA Newsletters

ln This lssue

From the President Carmine Piscopo, RCDD, ACUTA President

Board Report .............. Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

Tech Talk: Waiting for TechTalk 2.0, the New, lmproved Version................. Kevin Tanzillo, Dux PR

DC Update ... Jeanne Jansenius, Sewanee, The University of the South

Another Hit to the Cabling Budget: Electrician Shortage = Higher Cabling Costs............. Gary Audin

FYI: Useful lnformation from the Campus.................. Student Monitor

Web Tip: What's New at acuta.org?............. Aaron Fuehrer, ACUTA lnformation Technology Manager

Sign Up Today for Preconference Seminars

lnfo Links....................... Randy Hayes, Univ. of Northern lowa

ACUTA Web Seminar: lP Video …


Acuta Enews May 2007, Vol. 36, No. 5 May 2007

Acuta Enews May 2007, Vol. 36, No. 5

ACUTA Newsletters

ln This lssue

Nominees for ACUTA Board of Directors 07-08

From ACUTA Headquarters ....................... Jeri A. Semer, CAE, ACUTA Executive Director

Staff Changes at ACUTA Headquarters

Tech Talk: Med Center Keeps Legacy Equipment Alive in New Network............ Kevin Tanzillo, Dux PR

Overheard on the Listserv: Panic Button Quick Fix ...... Rob McCray, Delaware Tech.& Comm. College

Board Report ............ Riny Ledgerwood, San Diego State Univ. ACUTA Sec./Treasurer

DC Update.......... Jeanne Jansenius, Sewanee, The University of the South

ATlS Releases Standard on Surveillance

Dues Notices Mailed May 1

Technology Policies and User Expectations Focus of 2007 Strategic Leadership Forum

Web Tip: …


2007 Survey Of Summer Sessions Students At The University Of Nebraska-Lincoln, Paul Savory Apr 2007

2007 Survey Of Summer Sessions Students At The University Of Nebraska-Lincoln, Paul Savory

Department of Industrial and Management Systems Engineering: Faculty Publications

During Summer 2007, UNL Summer Sessions (FlexEd) surveyed summer students to learn about their experience in taking a summer course(s). The survey results will offer confirmation of what we are doing well and will provide guidance on areas of improvement and better strategies for marketing UNL summer opportunities. A total of 227 students completed the survey. Fifteen summer classes were selected to complete a paper-based or electronic version of the survey. The classes were from three different summer sessions and used different delivery mechanisms (on-campus, studio, distance education).


Acuta Enews April 2007, Vol. 36, No. 4 Apr 2007

Acuta Enews April 2007, Vol. 36, No. 4

ACUTA Newsletters

In This Issue

From the President.................... Carmine Piscopo, RCDD, ACUTA President

Nominate for ACUTA Ruth A. Michalecki Award

Board Report ............................ Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

Tech Talk: CMDB ls a Step Toward Seeing All, Knowing All.................. Kevin Tanzillo, Dux PR

DC Update................... Jeanne Jansenius, Sewanee, The University of the South

National LambdaRail and lnternet2 Renew Merger Discussions

FYI: Useful lnformation from the Campus............... Student Monitor

Web Tip: RSS Feed Technology............ Aaron Fuehrer, ACUTA lnformation Technology Manager

lnfo Links................ Randy Hayes, Univ of Northern lowa

Grants to Higher Ed from Microsemi

Welcome New Members


Peer Review Of Teaching Project, Paul Savory, Amy M. Goodbrun, Amy Nelson Burnett Mar 2007

Peer Review Of Teaching Project, Paul Savory, Amy M. Goodbrun, Amy Nelson Burnett

Department of Industrial and Management Systems Engineering: Faculty Publications

The national impact of UNL’s Peer Review of Teaching Project was recognized in 2005 – with a TIAA-CREF Hesburgh Certificate of Excellence – as an exceptional program in enhancing undergraduate student learning. In 2006, the project was designated an Institutional Leader by the Carnegie Foundation for the Advancement of Teaching and Learning. As a national institutional leader, the project will continue defining, measuring, tracking, and improving approaches that deepen student understanding.


Creating An Internet Repository For Course Portfolios, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett Mar 2007

Creating An Internet Repository For Course Portfolios, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett

Department of Industrial and Management Systems Engineering: Faculty Publications

Our ITLE grant has supported the development of www.courseportfolio.org – an internet repository for faculty-written course portfolios documenting best practices and evidence of student learning occurring in the classroom.


Acuta Enews March 2007, Vol. 36, No. 3 Mar 2007

Acuta Enews March 2007, Vol. 36, No. 3

ACUTA Newsletters

In This Issue

From ACUTA Headquarters Jeri A. Semer, CAE, ACUTA Executive Director

Board Report............... Riny Ledgerwood, San Diego State Univ. ACUTA Sec./Treasurer

Liability When Employees Use Cell Phones White Driving............. Brendan Carr, Wiley Rein LLP

Telecom Managers Profit from VolP Knowledge .................. Gary Audin, Delphi, lnc.

Tech Talk: Time for a Change? Yes, and lt's March 11............... Kevin Tanzillo, Dux PR

DC Update ............ Jeanne Jansenius, Sewanee, The University of the South

lnvite Your Vendors to Join ACUTA

FYI: Useful lnformation from the Campus Student Monitor

Web Tip: New RFI/RFP Web Page............. Aaron Fuehrer, ACUTA lnformation Technology Manager

ACUTA …


Acuta Enews February 2007, Vol. 36, No. 2 Feb 2007

Acuta Enews February 2007, Vol. 36, No. 2

ACUTA Newsletters

In This Issue

Nominate Now for ACUTA Board of Directors 2007-08

From the President.............. Carmine Piscopo, RCDD, Providence College

Nominations Still Open for Institutional Excellence Awards............. Pat Todus, Northwestern Univ.

Tech Talk: Visibility for Your School and ACUTA............. Kevin Tanzillo, Dux PR

DC Update............ Jeanne Jansenius, Sewanee, The University of the South

Overheard on the Listserv: Pricing VoIP

FYI: Useful Information from the Campus........... Student Monitor

Web Tip: What's New on ACUTA Website...... Aaron Fuehrer, ACUTA Information Technology Manager

Board Report.......... Riny Ledgerwood, San Diego State Univ., ACUTA Sec./Treasurer

Info Links............ Randy Hayes, Univ. of Northern Iowa

Remembering Harry Kyle …


Diversifying Biological Fuel Cell Designs By Use Of Nanoporous Filters, Justin C. Biffinger, Ricky Ray, Brenda Little, Bradley R. Ringeisen Jan 2007

Diversifying Biological Fuel Cell Designs By Use Of Nanoporous Filters, Justin C. Biffinger, Ricky Ray, Brenda Little, Bradley R. Ringeisen

U.S. Navy Research

The use of proton exchange membranes (PEMs) in biological fuel cells limits the diversity of novel designs for increasing output power or enabling autonomous function in unique environments. Here we show that selected nanoporous polymer filters (nylon, cellulose, or polycarbonate) can be used effectively in place of PEMs in a miniature microbial fuel cell (mini-MFC, device cross-section 2 cm2), generating a power density of 16 W/m3 with an uncoated graphite felt oxygen reduction reaction (ORR) cathode. The incorporation of polycarbonate or nylon membranes into biological fuel cell designs produced comparable power and durability to Nafion-117 membranes. Also, …


Genetically Attenuated Plasmodium Berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated By Major Histocompatibility Complex Class I–Dependent Interferon-Y–Producing Cd8+ T Cells, Ousman Jobe, Joanne Lumsden, Ann-Kristin Mueller, Jackie Williams, Hilda Silva-Rivera, Stefan H. I. Kappe, Robert J. Schwenk, Kai Matuschewski, Urszula Krzych Jan 2007

Genetically Attenuated Plasmodium Berghei Liver Stages Induce Sterile Protracted Protection That Is Mediated By Major Histocompatibility Complex Class I–Dependent Interferon-Y–Producing Cd8+ T Cells, Ousman Jobe, Joanne Lumsden, Ann-Kristin Mueller, Jackie Williams, Hilda Silva-Rivera, Stefan H. I. Kappe, Robert J. Schwenk, Kai Matuschewski, Urszula Krzych

US Army Research

At present, radiation-attenuated plasmodia sporozoites (y-spz) is the only vaccine that induces sterile and lasting protection in malaria-naive humans and laboratory rodents. However, g-spz are not without risks. For example, the heterogeneity of the y-spz could explain occasional breakthrough infections. To avoid this possibility, we constructed a double-knockout P. berghei parasite by removing 2 genes, UIS3 and UIS4, that are up-regulated in infective spz.We evaluated the double-knockout Pbuis3(-)/4(-) parasites for protective efficacy and the contribution of CD8+ T cells to protection. Pbuis3(-)/4(-) spz induced sterile and protracted protection in C57BL/6 mice. Protection was linked to CD8+ …


Acuta Enews January 2007, Vol. 36, No. 1 Jan 2007

Acuta Enews January 2007, Vol. 36, No. 1

ACUTA Newsletters

In This Issue

From ACUTA Headquarters........... Jeri A. Semer, CAE, ACUTA Executive Director

Centrex Conversion to PBX.............. Ron Walczak, Walczak Technology Consultants

Tech Talk: Duduplication Reduces Storage Needs............. Kevin Tanzillo, Dux PR

DC Update............... Jeanne Jansenius, Sewanee, The University of the South

ACUTA Alert: Federal Rules Governing Destruction of Electronically Stored Information

FYI: Useful Information from the Campus.............. Student Monitor

Setting Priorities............... Geoff Tritsch, Vantage Technology Consulting Group

Web Tip: Members Post Job Openings........... Aaron Fuehrer, ACUTA Information Technology Manager

Board Report............... Riny Ledgerwood, San Diego State Univ. of Northern Iowa

Thanks to Sponsors for 2006

A Moment in Time: …


Details And Description Of Operations Research, Paul Savory Jan 2007

Details And Description Of Operations Research, Paul Savory

Industrial and Management Systems Engineering: Reports

The ambiguous term operations research was coined during World War II. A frequent substitute is management science. Operations research is a scientific approach to analyzing problems and making decisions. It uses mathematics and mathematical modeling on computers to forecast the implications of various choices and zero in on the best alternatives. This content paper provides an overview of operations research. It highlights operations research problems, methods for solving problems, different areas of operations research, and example problems.


Pre/Post Assessment Of Abilities, Paul Savory Jan 2007

Pre/Post Assessment Of Abilities, Paul Savory

Industrial and Management Systems Engineering: Instructional Materials

One approach to assess if students are learning in a course is to conduct a pre-test, post-test assessment of the course material. By comparing the two results, one can make an assessment of the knowledge learned in the course. For certain types of courses, it can be a challenge in defining an assessment instrument that measure student knowledge. This example is one I have developed for my IMSE 440/840 (Discrete Event Computer Simulation) course. Students are asked rate their ability for key course objectives defined on the course syllabus. I administer it on the first day of the course and …


Peer Review Of Teaching Project: Overview Newsletter, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett Jan 2007

Peer Review Of Teaching Project: Overview Newsletter, Paul Savory, Amy M. Goodburn, Amy Nelson Burnett

Industrial and Management Systems Engineering: Reports

The Peer Review of Teaching Project (PRTP) is a UNL campus program that supports teams of faculty in making visible the serious intellectual work of teaching. Begun in 1994, the project uses the same process one would use to explore a research question by having faculty inquire, analyze, and document their teaching practices and the resulting student learning and then make these results accessible for use, review, and assessment by one’s peers. The project consists of a first-year fellowship program and an advanced scholar program. Specific faculty outcomes from participating in the project include: (1) Reflecting upon, developing, and writing …


A Dendroclimatic Record Of Paleoclimate Of The Last 10,000 Years, Glacier Bay National Park And Preserve: Progress Understanding Climate Change In Southeast Alaska, Daniel Lawson, Greg Wiles, David Finnegan Jan 2007

A Dendroclimatic Record Of Paleoclimate Of The Last 10,000 Years, Glacier Bay National Park And Preserve: Progress Understanding Climate Change In Southeast Alaska, Daniel Lawson, Greg Wiles, David Finnegan

US Army Research

Our investigations in 2007 focused on continuing collection and analyses of tree rings from living trees and building a long ring-width series from interstadial wood. These interstadial forests were extensive and their preservation, although discontinuous and fragmented, is remarkable. In situ stumps, still rooted in growth position, and logs held within sediments remain from forests that existed at various times between glaciations over approximately the last 10,000 years.
We have analyzed previous and new collections of ring-width tree-ring series, including a multiple species collection from near Excursion Ridge in the southeast portion of the Park. These tree-ring series have a …


Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides, Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C. K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun, Jonathan L. Vennerstrom Jan 2007

Weak Base Dispiro-1,2,4-Trioxolanes: Potent Antimalarial Ozonides, Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C. K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun, Jonathan L. Vennerstrom

US Army Research

Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.


Phase I Dose Escalation Safety And Immunogenicity Trial Of Plasmodium Falciparum Apical Membrane Protein (Ama-1) Fmp2.1, Adjuvanted With As02a, In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Mark E. Polhemus, Alan J. Magill, James F. Cummings, Kent E. Kester, Chris F. Ockenhouse, David E. Lanar, Sheetij Dutta, Arnoldo Barbosa, Lorraine Soisson, Carter L. Diggs, Sally A. Robinson, John D. Haynes, V. Ann Stewart, Lisa A. Ware, Clara Brando, Urszula Krzych, Robert A. Bowden, Joe D. Cohen, Marie-Claude Dubois, Opokua Ofori-Anyinam, Els De-Kock, W. Ripley Ballou, D. Gray Heppner Jr. Jan 2007

Phase I Dose Escalation Safety And Immunogenicity Trial Of Plasmodium Falciparum Apical Membrane Protein (Ama-1) Fmp2.1, Adjuvanted With As02a, In Malaria-Naive Adults At The Walter Reed Army Institute Of Research, Mark E. Polhemus, Alan J. Magill, James F. Cummings, Kent E. Kester, Chris F. Ockenhouse, David E. Lanar, Sheetij Dutta, Arnoldo Barbosa, Lorraine Soisson, Carter L. Diggs, Sally A. Robinson, John D. Haynes, V. Ann Stewart, Lisa A. Ware, Clara Brando, Urszula Krzych, Robert A. Bowden, Joe D. Cohen, Marie-Claude Dubois, Opokua Ofori-Anyinam, Els De-Kock, W. Ripley Ballou, D. Gray Heppner Jr.

US Army Research

We report the first safety and immunogenicity trial of the Plasmodium falciparum vaccine candidate FMP2.1/AS02A, a recombinant E. coli-expressed protein based upon the apical membrane antigen-1 (AMA-1) of the 3D7 clone formulated with the AS02A adjuvant. We conducted an open-label, staggered-start, dose-escalating Phase I trial in 23 malaria-naıve volunteers who received 8, 20 or 40 _g of FMP2.1 in a fixed volume of 0.5mL of AS02A on a 0, 1, and 2 month schedule. Nineteen of 23 volunteers received all three scheduled immunizations. The most frequent solicited local and systemic adverse events associated with immunization were injection site pain (68%) …


An In Vitro Comparative Study On The Reactivation Of Nerve Agent-Inhibited Guinea Pig And Human Acetylcholinesterases By Oximes, Chunyuan Luo, Min Tong, Nageswararao Chilukuri, Karen Brecht, Donald M. Maxwell, Ashima Saxena Jan 2007

An In Vitro Comparative Study On The Reactivation Of Nerve Agent-Inhibited Guinea Pig And Human Acetylcholinesterases By Oximes, Chunyuan Luo, Min Tong, Nageswararao Chilukuri, Karen Brecht, Donald M. Maxwell, Ashima Saxena

US Army Research

The reactivation of nerve agent-inhibited acetylcholinesterase (AChE) by oxime is the most important step in the treatment of nerve agent poisoning. Since the evaluation of nerve agent antidotes cannot be conducted in humans, results from animal experiments are extrapolated to humans. Guinea pig is one of the animal models that is frequently used for conducting nerve agent antidote evaluations. Several investigations have demonstrated that the efficacy of an oxime primarily depends on its ability to reactivate nerve agent-inhibited AChE. If the in Vitro oxime reactivation of nerve agent-inhibited animal AChE is similar to that of human AChE, it is likely …


Synthesis And Antimalarial Activity Of New Isotebuquine Analogues, Olga V. Miroshnikova, Thomas H. Hudson, Lucia Gerena, Dennis E. Kyle, Ai J. Lin Jan 2007

Synthesis And Antimalarial Activity Of New Isotebuquine Analogues, Olga V. Miroshnikova, Thomas H. Hudson, Lucia Gerena, Dennis E. Kyle, Ai J. Lin

US Army Research

Amodiaquine (AQ) and tebuquine are 4-aminoquinoline antimalarials with Mannich base side chain and are highly effective against chloroquine (CQ)-resistant strains of Plasmodium falciparum. Clinical use of AQ has been severely restricted due to hepatoxicity and agranulocytosis side effects associated with its long term use. Lysosomal accumulation and bioactivation to generate reactive quinoneimine metabolite are implicated to be the cause of the observed AQ toxicities. To avoid the quinoneimine formation and thus the toxicity, a series of isotebuquine analogues and their Nω-oxides with hydroxy group meta to the amino rather than in para position of the aniline moiety …


Remediation Of Rdx- And Hmx-Contaminated Groundwater Using Organic Mulch Permeable Reactive Barriers, Farrukh Ahmad, Stephen P. Schnitker, Charles J. Newell Jan 2007

Remediation Of Rdx- And Hmx-Contaminated Groundwater Using Organic Mulch Permeable Reactive Barriers, Farrukh Ahmad, Stephen P. Schnitker, Charles J. Newell

US Army Research

Organic mulch is a complex organic material that is typically populated with its own consortium of microorganisms. The organisms in mulch breakdown complex organics to soluble carbon, which can then be used by these and other microorganisms as an electron donor for treating RDX and HMX via reductive pathways. A bench-scale treatability study with organic mulch was conducted for the treatment of RDX- and HMX-contaminated groundwater obtained from a plume at the Pueblo Chemical Depot (PCD) in Pueblo, Colorado. The site-specific cleanup criteria of 0.55 ppb RDX and 602 ppb HMX were used as the logical goals of the study. …


Army Research Needs For Automated Neuropsychological Tests: Monitoring Soldier Health And Performance Status, Karl E. Friedl, Stephen J. Grate, Susan P. Proctor, James W. Ness, Brian J. Lukey, Robert L. Kane Jan 2007

Army Research Needs For Automated Neuropsychological Tests: Monitoring Soldier Health And Performance Status, Karl E. Friedl, Stephen J. Grate, Susan P. Proctor, James W. Ness, Brian J. Lukey, Robert L. Kane

US Army Research

Information on the mental status of soldiers operating at the limits of human tolerance will be vital to their management in future deployments; it may also allow earlier intervention for conditions such as undiagnosed Gulf War illnesses and Parkinson’s Disease. The Army needs a parsimonious set of neuropsychological tests that reliably identify subtle changes for: (1) early detection of individual health and military performance impairments and (2) management of occupational and deployment health risks. Testing must characterize cognitive lapses in healthy individuals faced with relevant operational stressors (i.e., anxiety, information overload, thermal strain, hypoxia, fatigue, head impact, chemical or radiation …