Operations Research, Systems Engineering and Industrial Engineering Commons^™

On Valuing Biopharmaceutical Product Pipelines: An Effectuation Model And Evidence, Mark J. Ahn, Anne S. York, Wei Wu, Yulianto Suharto, Tugrul Unsal Daim

Engineering and Technology Management Faculty Publications and Presentations

New creative approaches are needed to manage emerging biotechnology innovations, regulations, and payor environments to enhance product pipeline productivity, valuation, and risk management. Biopharmaceutical firms must make dynamic resource allocation decisions on their relative levels of internal R&D and external strategic alliances in furthering their pipelines. As the predominant method of using discounted cash flow (DCF) methodologies may lead to chronic underinvestment and performance, we evaluated the integration of traditional DCF with an effectuation model of analysis. Unlike traditional financial models that begin with the end goal of assumed known cash flows and recursively solve for portfolio optimization, the effectuation …

The Prediction Predicament, William "Ike" Eisenhauer

Engineering and Technology Management Faculty Publications and Presentations

The article focuses on the prediction of predicament in terms of forecasting at industrial engineering level. Topics discussed include business optimize resources via forecasting; audience who cannot comprehend the methodology used for forecasting in healthcare operations; and use of forecasting for performance measurement.

The Time Has Come For Nursing Engineering, William "Ike" Eisenhauer

Engineering and Technology Management Faculty Publications and Presentations

The article discusses the need for healthcare and educational organizations to create nursing engineering program. Topics discussed include successes in healthcare systems as engineers and healthcare professionals, integration of industrial engineering or lean and Six Sigma courses into nursing programs of the University of Alabama and modern healthcare system and modern healthcare participants that can be addressed by the new profession.

Don't Go Chasing Big Waterfalls, William "Ike" Eisenhauer

Engineering and Technology Management Faculty Publications and Presentations

The article focuses on the importance of simpler health systems in the U.S. Topics discussed include success of simple systems as they are well-understood, improvement of simple systems by coupling them together, handling more patient cases by larger systems by the medical laboratory technicians giving complicated results and designing simple systems by health system engineers to deal with fewer problematic cases of patients with more efficacy.

Design, Programming, And User-Experience, Kaila G. Manca

Honors Scholar Theses

This thesis is a culmination of my individualized major in Human-Computer Interaction. As such, it showcases my knowledge of design, computer engineering, user-experience research, and puts into practice my background in psychology, com- munications, and neuroscience.

I provided full-service design and development for a web application to be used by the Digital Media and Design Department and their students.This process involved several iterations of user-experience research, testing, concepting, branding and strategy, ideation, and design. It lead to two products.

The first product is full-scale development and optimization of the web appli- cation.The web application adheres to best practices. It was …

Energy Harvesting And Storage: The Catalyst To The Power Constraint For Leveraging Internet Of Things (Iot) On Trains, Kelechi Nwogu

Computer and Electronics Engineering: Dissertations, Theses, and Student Research

The success of Wireless Sensor Networks is heavily constrained by its reliance on storage technology like batteries, which are a finite resource. Whilst the number of transistors in an IC doubles every 18 months, the energy density of batteries is relatively flat during the same time period. This is a key challenge in leveraging the Internet of Things on trains.

The gravity of this problem is increased by an order of magnitude when the network is to be scaled up to hundreds or thousands of nodes. Comprehensive research and development efforts have been devoted to building ultra-low power sensors. These …

Cloud Computing, Contractibility, And Network Architecture, Christopher S. Yoo

All Faculty Scholarship

The emergence of the cloud is heightening the demands on the network in terms of bandwidth, ubiquity, reliability, latency, and route control. Unfortunately, the current architecture was not designed to offer full support for all of these services or to permit money to flow through it. Instead of modifying or adding specific services, the architecture could redesigned to make Internet services contractible by making the relevant information associated with these services both observable and verifiable. Indeed, several on-going research programs are exploring such strategies, including the NSF’s NEBULA, eXpressive Internet Architecture (XIA), ChoiceNet, and the IEEE’s Intercloud projects.

Toward Agent-Based Modeling Of The U.S. Department Of Defense Acquisition System, Karl Schwenn, John M. Colombi, Theresa Wu, Kyle F. Oyama, Alan W. Johnson

Faculty Publications

The systems development, procurement and sustainment of a nation's military equipment is vital to its national interests, but the process is complex, constantly changing and highly adaptive, as well as time consuming and costly. The U.S. Department of Defense (DoD) expends both large amounts of capital and manpower to equip its armed forces. This research seeks to identify opportunities to gain better insight into the functioning of the defense acquisition system, building on previous simulations. A case is made that the DoD Requirements, Planning Acquisition, Technology and Logistics System is a complex adaptive system that has characteristics appropriate for exploration …

Bus Rapid Transit (Brt) Toolbox: Brt Person Throughput-Vehicle Congestion Tradeoffs, Li Jingquan, H.-S. Jacob Tsao, Ching-Yao Chan, Kun Zhou, Wei-Bin Zhang

Faculty Publications

This report documents a research effort to understand the current practice and issues associated with Bus Rapid Transit (BRT) planning and deployment. It reviewed the design options incorporated into existing BRT deployments across California and the nation. The project team interviewed practitioners of California Department of Transportation (Caltrans) Districts and transit agencies to understand the BRT project approval decision-making process, the impacts of BRT implementation and the Measures of Effectiveness (MOEs) for transit and non-transit system performance. The studies revealed that though Caltrans and transit agencies do use a similar set of MOEs for the evaluation of BRT projects, the …

A General Intuitive Design Pattern For Optimally Sequencing Treatment Combinations In 2k Factorial Experiment And A Simple Estimation Algorithm, H.-S. Jacob Tsao, Minnie Patel

Faculty Publications

The number of model parameters of a 2k factorial design grows exponentially. When the number of factors is large, numerous higher-order interactions constitute a vast majority of the model parameters while many of them do not exist or are insignificant. The classic methods of fractional factorial designs, Plackett–Burman designs, Taguchi designs, etc. seek an already developed and often cataloged design that fits exactly the problem being tackled or select a design that fits it the most. Most, if not all, of these designs were developed in absence of convenient computation tools and enjoy computational simplicity. The necessary number of treatment …

A Human-Centered Credit-Banking System For Convenient, Fair And Secure Carpooling Among Members Of An Association, H.-S. Jacob Tsao, Magdalini Eirinaki

Faculty Publications

This paper proposes an unconventional carpool-matching system concept that is different from existing systems with four innovative operational features: (F1) The proposed matching system will be used by members of an association and sponsored by the association, e.g., the employees of a company, members of a homeowner association, employees of a shopping center. This expands the scope beyond commute trips. Such associations can also voluntarily form alliances to increase the number of possible carpool partners and geographical reach. (F2) Service provided by a driver or received by a rider incurs credit or debt to a bank centrally and fairly managed …

Planning Rural Water Services In Nicaragua: A Systems-Based Analysis Of Impact Factors Using Graphical Modeling, Jeffrey P. Walters, Paul S. Chinowsky

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

The success or failure of rural water services in the developing world is a result of numerous factors that interact in a complex set of connections that are difficult to separate and identify. This research effort presented a novel means to empirically reveal the systemic interactions of factors that influence rural water service sustainability in the municipalities of Darío and Terrabona, Nicaragua. To accomplish this, the study employed graphical modeling to build and analyze factor networks. Influential factors were first identified by qualitatively and quantitatively analyzing transcribed interviews from community water committee members. Factor influences were then inferred by graphical …

Long-Term Functionality Of Rural Water Services In Developing Countries: A System Dynamics Approach To Understanding The Dynamic Interaction Of Causal Factors, Jeffrey P. Walters, Amy N. Javernick-Will

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Research has shown that sustainability of rural water infrastructure in developing countries is largely affected by the dynamic and systemic interactions of technical, social, financial, institutional, and environmental factors that can lead to premature water system failure. This research employs systems dynamic modeling, which uses feedback mechanisms to understand how these factors interact dynamically to influence long-term rural water system functionality. To do this, the research first identified and aggregated key factors from literature, then asked water sector experts to indicate the polarity and strength between factors through Delphi and cross impact survey questionnaires, and finally used system dynamics modeling …

Management Of Rural Water Services In Nicaragua: A Systematic Network Approach To Evaluating Stakeholder Alignment, Jeffrey P. Walters, Amy N. Javemick-Will

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

Water sector literature attributes a substantial cause of rural water system failure in developing countries to poor alignment between water service stakeholders. This study aimed to investigate a means for assessing stakeholder alignment by comparing the systemic interaction of stakeholder values, where the term ‘stakeholder values’ refers to aspects stakeholders believe are necessary to ensure rural water services are sustainable. The research held focus groups with key stakeholder groups involved in the management of rural water infrastructure in Terrabona, Nicaragua, to identify stakeholder values, and then used cross-impact analysis to evaluate how these values interacted to form stakeholder value networks …

Challenges For Developing Complex System Governance, Charles B. Keating, Polinpaplinho F. Katina, Joseph M. Bradley, Sila Çetinkaya (Ed.), J. K. Ryan (Ed.)

Engineering Management & Systems Engineering Faculty Publications

This paper examines the challenges and practice implications for Complex System Governance (CSG). CSG is presented as an emerging field focused on the design, execution, and evolution of the higher order (metasystem) functions necessary to provide control, communication, coordination, and integration of a complex system. This paper is focused on three primary objectives. First, we introduce the complex system problem domain that the CSG field is being designed to address. The pervasiveness of this problem domain is demonstrated by a short examination of the water utilities sector. Second, we expound the nature of CSG and an emerging reference model …

Reducing Uncertainty In Technology Selection For Long Life Cycle Engineering Designs, Halil I. Ozdemir, C. Ariel Pinto, Resit Unal, Charles B. Keating, Colin Britcher, Sila Çetinkaya (Ed.), J. K. Ryan (Ed.)

Engineering Management & Systems Engineering Faculty Publications

The best capabilities are usually achieved by having the latest technologies in defense systems. However, including the new, usually immature, technologies in a system design does not always easily result in achieving the capabilities at the right level, at an affordable cost, and in a timely manner. Many programs have suffered from immature technologies as cost overruns, late or no deliveries, and poor performance levels. Another impact of technology selection appears as obsolescence after the deployment of systems, or even before the deployment of the system. As the technologies of a system become obsolete, the cost of maintaining the system …

Learning By Doing - Energy Systems Management, Nima Shahriari, Adrian V. Gheorghe

Engineering Management & Systems Engineering Faculty Publications

Climate change concerns have confronted energy policy makers by unprecedented challenges in the 21st century. Revolution of renewable energy technologies, as well as more efficient energy systems, has been promising in the context of global warming. However, these technologies are not maturing and chaning. Consequently planning for development of these resources requires dealing with various multidisciplinary research questions such as financial feasibility of renewable energy projects. Nevertheless, there is considerable lack of education programs offering multidisciplinary approach for addressing the current energy challenges. Based on the 21st evolving energy landscape, an interdisciplinary graduate certificate course work was designed at Old …

How System Errors Affect Aircrew Resource Management (Crm), Justin Y. Adkins, Kevin Macg. Adams, Patrick T. Hester

Engineering Management & Systems Engineering Faculty Publications

System errors, both mechanical and human in nature, can have a grave effect on aircrew judgement in flight. The effects of these errors can be massively compounded during emergency situations. Crew Resource Management (CRM) is an important process aircrews can utilize to minimize risks and enhance assessments. The employment of this technique can be validated by aviation mishaps over the last three decades and how system errors increased the probability of the incident occurring. Suggestions can be made to further prevent similar accidents from occurring in the future utilizing historical aeronautical records. This paper outlines an approach by which systems …

An Agent Based Approach For Simulating Demo Enterprise Models, Mamadou Seck, Joseph Barjis

Engineering Management & Systems Engineering Faculty Publications

DEMO (design and engineering methodology for organization) is a theoretically grounded methodology for rigorous enterprise modeling. It provides relevant concepts from a construction perspective. As the methodology gains a wider audience, there is a growing interest in simulating DEMO models. Most attempts to develop a simulation approach for enterprise models in general, and the DEMO methodology in particular, are based on process oriented conceptualizations that are typically implementation in a discrete event paradigm. In this paper, we propose a conceptual framework for the translation of DEMO models into an agent based simulation. We will describe the DEMO methodology in some …

Analyzing Stakeholders Using Fuzzy Cognitive Mapping, Patrick T. Hester

Engineering Management & Systems Engineering Faculty Publications

Stakeholder analysis was first explored as a methodology to assist business leaders with their strategic management functions. Stakeholder analysis has since expanded beyond the corporate arena. Stakeholders are a vital element in all complex systems problems; they are the customers, users, clients, suppliers, employees, regulators, and team members of a system. They fund a system, design it, build it, operate it, maintain it, and dispose of it. Each stakeholder contributes their own value-added perspective, as described by the systems principle known as complementarity. While many approaches exist for classifying and determining their attitudes, these approaches stop short of evaluating stakeholders …