Operations Research, Systems Engineering and Industrial Engineering Commons^™

On Valuing Biopharmaceutical Product Pipelines: An Effectuation Model And Evidence, Mark J. Ahn, Anne S. York, Wei Wu, Yulianto Suharto, Tugrul Unsal Daim

Engineering and Technology Management Faculty Publications and Presentations

New creative approaches are needed to manage emerging biotechnology innovations, regulations, and payor environments to enhance product pipeline productivity, valuation, and risk management. Biopharmaceutical firms must make dynamic resource allocation decisions on their relative levels of internal R&D and external strategic alliances in furthering their pipelines. As the predominant method of using discounted cash flow (DCF) methodologies may lead to chronic underinvestment and performance, we evaluated the integration of traditional DCF with an effectuation model of analysis. Unlike traditional financial models that begin with the end goal of assumed known cash flows and recursively solve for portfolio optimization, the effectuation …

The Application Of Gage R&R Analysis In S Six Sigma Case Of Improving And Optimizing An Automotive Die Casting Product’S Measurement System, Qizheng Ren

Masters Theses & Specialist Projects

With the rapid development of automation technology in automotive manufacturing processes, massive and efficient production is a current trend. Therefore, measurement systems with accurate and automated measuring instruments are sought by automotive companies and suppliers. However, the problematic measuring instruments with unreliable accuracy and stability lead to erroneous measurements and wrong quality decisions that cause manufacturers huge profit losses. An effective method called “measurement system analysis” can be applied to define and eliminate erroneous measurements to ensure adequate reliability. An automotive transmission die casting parts supplier called company T was suffering a serious profit loss due to the erroneous measurements …

Mapping Kinematic Functional Abilities Of The Hand To Three Dimensional Shapes For Inclusive Design, Samuel T. Leitkam, Laura Bix, Javier De La Fuente, Tamara Reid Bush

Industrial Technology and Packaging

Loss of hand function can have adverse effects on an individual's ability to maintain independence. The ability to perform daily activities, such as food preparation and medication delivery, is dependent on the hand's ability to grasp and manipulate objects. Therefore, the goal of this research was to demonstrate that three dimensional (3D) modeling of hand function can be used to improve the accessibility of handheld objects for individuals with reduced functionality through informed design. Individual models of hand functionality were created for 43 participants and group models were developed for groups of individuals without (Healthy) and with reduced functionality due …

The Influence Of Cu3(Btc)2 Metal Organic Framework On The Permeability And Perm-Selectivity Of Plla-Mof Mixed Matrix Membranes, Ajay Kathuria, Saleh Al-Ghamdi, Mohamad G. Abiad, Rafael Auras

Industrial Technology and Packaging

Poly(l-lactic acid) (PLLA) - 20% (w/w) and Cu₃(BTC)₂ metal organic framework (MOF) based mixed matrix membranes (MMMs) were fabricated by a vertical corotating twin screw microcompounder followed by an injection molding process. Water vapor, CO_2, O₂, and selected aroma mass transfer properties of PLLA and PLLA MMMs were evaluated. The CO₂/O₂ perm-selectivity of PLLA (α_CO2/O2) MMMs increased from 7.6 to 10.3 with the incorporation of 20% Cu₃(BTC)₂ MOF. Gravimetric permeability studies of trans-2-hexenal performed at 23°C and 50% RH indicated that permeability coefficient of PLLA MMMs …

A Case Study Of Multiple-Use Finish Electrodes For Die-Sinking Edm, Troy A. Robertson

Masters Theses & Specialist Projects

This study examines the use of one finishing electrode to finish multiple dies without remachining the electrode. The multiple-use electrode finishing experiment in this study addresses technology in the die-forging industry. Methods of manufacturing spherical straight bevel forge gear dies have relied on die-sinking Electrical Discharge Machining (EDM) practices that showed great potential for advancement. The focus of this study is solely on the improvements of electrode use in EDM finishing-processes. The surface finish quality itself is not an area of concern other than maintaining that it does not diminish. The focused concern is maximizing the process by using one …

Design, Programming, And User-Experience, Kaila G. Manca

Honors Scholar Theses

This thesis is a culmination of my individualized major in Human-Computer Interaction. As such, it showcases my knowledge of design, computer engineering, user-experience research, and puts into practice my background in psychology, com- munications, and neuroscience.

I provided full-service design and development for a web application to be used by the Digital Media and Design Department and their students.This process involved several iterations of user-experience research, testing, concepting, branding and strategy, ideation, and design. It lead to two products.

The first product is full-scale development and optimization of the web appli- cation.The web application adheres to best practices. It was …

An Affordance-Based Methodology For Package Design, Javier De La Fuente Phd, Stephanie Gustafson, Colleen L. Twomey, Laura Bix

Industrial Technology and Packaging

The term affordance describes an object's utilitarian function or actionable possibilities. Product designers have taken great interest in the concept of affordances because of the bridge they provide relating to design, the interpretation of design and, ultimately, functionality in the hands of consumers. These concepts have been widely studied and applied in the field of psychology but have had limited formal application to packaging design and evaluation. We believe that the concepts related to affordances will reveal novel opportunities for packaging innovation. To catalyse this, presented work had the following objectives: (a) to propose a method by which packaging designers …

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Technology Faculty Publications and Presentations

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva^™ Handihaler, Advair Diskus^™, and Pulmicort^™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …

Reducing Uncertainty In Technology Selection For Long Life Cycle Engineering Designs, Halil I. Ozdemir, C. Ariel Pinto, Resit Unal, Charles B. Keating, Colin Britcher, Sila Çetinkaya (Ed.), J. K. Ryan (Ed.)

Engineering Management & Systems Engineering Faculty Publications

The best capabilities are usually achieved by having the latest technologies in defense systems. However, including the new, usually immature, technologies in a system design does not always easily result in achieving the capabilities at the right level, at an affordable cost, and in a timely manner. Many programs have suffered from immature technologies as cost overruns, late or no deliveries, and poor performance levels. Another impact of technology selection appears as obsolescence after the deployment of systems, or even before the deployment of the system. As the technologies of a system become obsolete, the cost of maintaining the system …

Size Effects In Human Visual Inspection For Micro/Meso Scale Parts, Sri Harsha Kavuri

Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research

Visual inspection has been a major method of quality control in conventional manufacturing processes for the last fifty years. Utilizing trained human inspectors to perform this visual inspection has been the most effective means of maintaining quality control. Extensive research has been performed to understand the factors that influence the human inspection process.

In the recent years, there has been a significant emphasis on manufacturing at the smaller end of the size-spectrum such as Micro and Meso scale manufacturing. Quality control at becomes a challenging task due to the extremely small sizes. Several automated visual inspection techniques have been proposed …