Operations Research, Systems Engineering and Industrial Engineering Commons^™

Investigations Of Transcript Expression In Fathead Minnow (Pimephales Promelas) Brain Tissue Reveal Toxicological Impacts Of Rdx Exposure, Kurt A. Gust, Mitchell S. Wilbanks, Xin Guan, Mehdi Pirooznia, Tanwir Habib, Leslie Yoo, Henri Wintz, Chris D. Vulpe, Edward J. Perkins

US Army Research

Production, usage and disposal of the munitions constituent (MC) cyclotrimethylenetrinitramine (RDX) has led to environmental releases on military facilities. The chemical attributes of RDX are conducive for leaching to surface water which may put aquatic organisms at risk of exposure. Because RDX has been observed to cause aberrant neuromuscular effects across a wide range of animal phyla, we assessed the effects of RDX on central nervous system (CNS) functions in the representative aquatic ecotoxicological model species, fathead minnow (Pimephales promelas). We developed a fathead minnow brain-tissue cDNA library enriched for transcripts differentially expressed in response to RDX and …