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Full-Text Articles in Operations Research, Systems Engineering and Industrial Engineering
Activity Of Topical Antimicrobial Agents Against Multidrug-Resistant Bacteria Recovered From Burn Patients, Jessie S. Glasser, Charles H. Guymon, Katrin Mende, Steven E. Wolf, Duane R. Hospenthal, Clinton K. Murray
Activity Of Topical Antimicrobial Agents Against Multidrug-Resistant Bacteria Recovered From Burn Patients, Jessie S. Glasser, Charles H. Guymon, Katrin Mende, Steven E. Wolf, Duane R. Hospenthal, Clinton K. Murray
US Army Research
Background:
Topical antimicrobials are employed for prophylaxis and treatment of burn
wound infections despite no established susceptibility breakpoints, which are becoming vital in an era of multidrug-resistant (MDR) bacteria. We compared two methods of determining topical antimicrobial susceptibilities.
Methods:
Isolates of Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus (MRSA), extended spectrum beta-lactamase (ESBL) producing Klebsiella pneumoniae, and Acinetobacter baumanii-calcoaceticus (ABC) from burn patients were tested using broth microdilution and agar well diffusion to determine minimum inhibitory concentrations (MICs) and zones of inhibition (ZI). Isolates had systemic antibiotic resistance and clonality determined. MDR included resistance to antibiotics in three or more …