Operations Research, Systems Engineering and Industrial Engineering Commons^™

A Machine Learning Approach For Predicting Clinical Trial Patient Enrollment In Drug Development Portfolio Demand Planning, Ahmed Shoieb

Masters Theses

One of the biggest challenges the clinical research industry currently faces is the accurate forecasting of patient enrollment (namely if and when a clinical trial will achieve full enrollment), as the stochastic behavior of enrollment can significantly contribute to delays in the development of new drugs, increases in duration and costs of clinical trials, and the over- or under- estimation of clinical supply. This study proposes a Machine Learning model using a Fully Convolutional Network (FCN) that is trained on a dataset of 100,000 patient enrollment data points including patient age, patient gender, patient disease, investigational product, study phase, blinded …

Two Multi-Objective Stochastic Models For Project Team Formation Under Uncertainty In Time Requirements, Fahimeh Rahmanniyay

Masters Theses

Team formation is one of the key stages in project management. The cost associated with the individuals who form a team and the quality of the tasks completed by the team are two of the main concerns in team formation problems. In this study, two mathematical models to optimize simultaneously cost and quality in a team formation problem are developed. Because team formation problem arises in uncertain environment, different scenarios are defined for the time requirement of the project. Two-stage stochastic programming and multi-stage stochastic programming are applied to solve the first and the second model respectively. The presented models …

Integration Of Maintenance Into Design And Sustainability Of Buildings, Dinesh Reddy Patlolla

Masters Theses

Custodial maintenance is an important aspect of operational maintenance in a facility. Custodial maintenance improves an organization's discipline, performance and keeps surroundings healthy. That being said maintaining clean surroundings involves considerable cost. Custodial maintenance cost forms significant portion of building budgets, however these costs are often neglected. This research deals with the identification of variables that affect maintenance costs in a facility and reduction of maintenance costs. The minimization of cost is done by giving the administrator or facilities manager the option of selecting alternatives in frequency of maintenance, level of maintenance and the number of people required to complete …

An Experimental Approach For Developing Rfid Ready Receiving And Shipping, Amoldeep Singh Jaggi

Masters Theses

Abstract:

Radio Frequency Identification (RFID) and related technologies have been touted to allow exponential improvements in supply chain logistics and management. However, many industrial users have indicated that these technologies have not provided the anticipated benefits. The two complimentary strategies required to address the RFID reliability are: to improve the reliability of RFID technology and to design the supply chain infrastructure that enables RFID. The focus of this paper is on designing the supply chain infrastructure to enable RFID by developing guidelines for “RFID Ready Facilities”. These guidelines were developed based on a set of experiments conducted in the RFID …

Interaction Between Primary Resources And Root Causes In Lean Production Systems, Ernest Anene Iwuchukwu

Masters Theses

A model to analyze lean systems reliability is developed based on the premises that lean production systems require four primary resources; materials, equipment, personnel, and schedule (Sawhney, R., Subburaman, K., Sonntag, C., Capizzi, C. and Rao, P.V., 2009). The four primary lean resources were independently analyzed, without due consideration to underlying relationships within each other. In this research, relationships and interaction between root-causes and lean primary resources were conceptualized and developed. The development applied a five-phase approach: 1. review of related literature, 2. decompositions of lean primary resources, 3. selection of consensus root causes items and questionnaire construct, 4. survey …

Analyzing Supercomputer Utilization Under Queuing With A Priority Formula And A Strict Backfill Policy, Michael David Vanderlan

Masters Theses

Supercomputers have become increasingly important in recent years due to the growing amount of data available and the increasing demand for quicker results in the scientific community. Since supercomputers carry a high cost to build and maintain, efficiency becomes more important to the owners, administrators, and users of these supercomputers. One important factor in determining the efficiency of a supercomputer is the scheduling of jobs that are submitted by users of the system. Previous work has dealt with optimizing the schedule on the system’s end while the users are blinded from the process. The work presented in this thesis investigates …